☆ 4.7 Review

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

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Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

Binbin Ding et al.

Summary: This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy, which can release ions to induce intracellular osmotic imbalance and trigger cell death mechanisms. In vivo tests confirm that ZrNPs-induced pyroptosis exhibits superior antitumor immunity activity, inhibiting tumor growth and pulmonary metastasis.

NANO LETTERS (2021)

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Review Immunology

NLRP3 inflammasome in cancer and metabolic diseases

Bhesh Raj Sharma et al.

Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.

NATURE IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

A Virus-Spike Tumor-Activatable Pyroptotic Agent

Sadia Nadeem et al.

Summary: The study presents a virus-spike tumor-activatable pyroptotic agent for cancer-specific therapy, which can induce pyroptosis in tumor cells. This agent can accumulate in tumors after systemic administration and be degraded by intracellular glutathione to activate inflammasomes and lead to pyroptotic cell death. This structure-dependent and tumor intracellular GSH activatable pyroptotic agent represents a novel paradigm for cancer-specific pyroptotic nanomedicine development.

SMALL (2021)

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Article Pharmacology & Pharmacy

Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis

Lin Gao et al.

Summary: This study reveals the critical role of NLRP3 inflammasome and GSDMD activation-mediated pyroptosis in acinar cells, linking pancreatic necrosis and systemic inflammation in acute pancreatitis. Targeting pyroptosis signaling pathways holds promise for specific therapy for acute pancreatitis.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Cell Biology

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Jia-yuan Zhang et al.

Summary: Pyroptosis is induced by alpha-ketoglutarate through caspase-8-mediated cleavage of GSDMC. This process involves elevation of ROS levels leading to oxidation of DR6 and endocytosis, ultimately resulting in pyroptosis. The acidic environment and production of L-2HG play a crucial role in enhancing the efficiency of alpha-KG-induced pyroptosis in cancer cells.

CELL RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Microenvironment-Responsive Prodrug-Induced Pyroptosis Boosts Cancer Immunotherapy

Yao Xiao et al.

Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.

ADVANCED SCIENCE (2021)

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Review Chemistry, Medicinal

Alzheimer's disease and its treatment by different approaches: A review

Sukriti Srivastava et al.

Summary: Alzheimer's disease is a neurodegenerative disorder that impairs mental ability development and interrupts neurocognitive function. Current treatments only provide symptomatic relief with no cure available yet. Nanotechnology and stem cell-based therapy are seen as promising approaches to overcome the obstacles in treating AD.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Immunology

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

Megan H. Orzalli et al.

Summary: During viral infection, inhibition of protein synthesis triggers pyroptosis in human keratinocytes, leading to the release of inflammatory cytokines. MCL-1 and BCL-xL act as sensors of translation shutdown, contributing to antiviral defense by inhibiting virus replication.

IMMUNITY (2021)

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Review Pharmacology & Pharmacy

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

Yuan-Pin Hung et al.

Summary: Bacteria-targeting nanomaterials have been widely used for diagnosis and treatment of bacterial infectious diseases, showing great potential as antimicrobial agents. These materials prevent bacterial colonization and spreading, benefiting biomaterial implants. Tailoring nanomaterials for wound repair and incorporating immune activating adjuvants can improve function and prevent bacterial infections.

PHARMACEUTICS (2021)

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Review Oncology

Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al.

Summary: Pyroptosis is an inflammatory form of cell death with tumor suppressive function and the ability to evoke anti-tumor immune responses. Cancer therapies induce pyroptosis, enhancing anti-tumor immunity, but also leading to side effects on normal cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Pharmacology & Pharmacy

Gasdermin D in pyroptosis

Brandon E. Burdette et al.

Summary: Pyroptosis is a process of inflammatory cell death that defends the host against microbe infection, but excessive pyroptosis can lead to inflammatory diseases. The cleavage of GsdmD is essential for pyroptosis, releasing cytokines and causing cell death, playing a crucial role in inflammatory diseases.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Nanoscience & Nanotechnology

Engineered Biomimetic Nanoplatform Protects the Myocardium Against Ischemia/Reperfusion Injury by Inhibiting Pyroptosis

Yazhong Wei et al.

Summary: PDA@M, a nanoplatform, can target infarcted myocardium to provide antioxidative and antipyroptosis functions for myocardial protection against MI/RI-induced oxidative stress. The results demonstrate that PDA@M significantly reduces infarct size and improves cardiac function post-MI/RI.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

Kuikun Yang et al.

Summary: A supramolecular nanoparticle has been developed for chemodynamic therapy, which can release radicals and platinum (IV) prodrug in tumors to enhance H2O2 generation. The nanoparticles can be readily excreted via renal clearance to avoid systemic toxicity, providing potential for novel cascade chemo/chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Physical

Metabolizable Photosensitizer with Aggregation-Induced Emission for Photodynamic Therapy

Wenbo Wu et al.

Summary: A highly efficient metabolizable type-II photosensitizer with aggregation-induced emission characteristics was developed in this study, demonstrating good anti-tumor PDT efficiency in mouse models. Importantly, the photosensitizer can be gradually oxidized by endogenous hypochlorite after PDT and subsequently excreted through urine within 24 hours of administration.

CHEMISTRY OF MATERIALS (2021)

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Review Oncology

Nanomaterials for cancer therapy: current progress and perspectives

Zhe Cheng et al.

Summary: Nanomaterials play an important role in cancer therapy by targeting cancer cells, tumor microenvironment, and the immune system. However, despite an increasing number of studies, the approval of nano-drugs has not significantly increased, requiring further research to improve clinical translation efficiency.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Nanoscience & Nanotechnology

Nanotechnology applications for cardiovascular disease treatment: Current and future perspectives

Dennis K. Wang et al.

Summary: The majority of cardiovascular nanomedicine research focuses on fabricating designer nanoparticles for improved targeting to overcome biological barriers. Innovative nano-drug carriers can modulate inflammatory processes and deliver therapeutic payloads locally to plaque, advancing therapeutic efficacy for various cardiac disease indications. Attention should be placed on nanotechnological approaches for risk factor treatment to aid in early prevention and treatment of cardiovascular diseases as they claim a significant number of lives globally.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Article Chemistry, Multidisciplinary

An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy

Kewei Wang et al.

Summary: The near-infrared dye CyNH2 can selectively induce pyroptosis in cancer cells through NQO1 response, leading to systemic activation of antitumor immunity.

SMALL (2021)

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Article Multidisciplinary Sciences

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

Lindsey Mayes-Hopfinger et al.

Summary: WNK1 is identified as a negative regulator of the NLRP3 inflammasome, balancing intracellular Cl- and K+ concentrations to suppress NLRP3 activation and reduce inflammatory responses.

NATURE COMMUNICATIONS (2021)

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Review Medicine, Research & Experimental

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

Jinning Gao et al.

Summary: Cardiovascular disease is a critical threat to human life, and recent studies have shown the important roles of inflammation and pyroptosis in its progression. Noncoding RNAs are considered promising biomarkers and therapeutic targets for diagnosing and treating cardiovascular diseases.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Oncology

Pyroptosis, metabolism, and tumor immune microenvironment

Tiantian Du et al.

Summary: GSDM proteins play crucial roles in pyroptosis, and the impact of inflammatory characteristics induced by pyroptosis on the host depends on the context, timing, and response degree. Targeting pyroptosis may uncover potential therapeutic avenues in various metabolic diseases and the tumor microenvironment.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy

Yi Zuo et al.

Summary: Pyroptosis is a programmed cell death mechanism related to Caspase-1, triggering inflammatory reactions by releasing proinflammatory factors. GSDMD plays a key role in pyroptosis, and recent studies have highlighted its importance in the occurrence and development of diabetic nephropathy.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2021)

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Article Critical Care Medicine

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Yang Jiao et al.

Summary: The study demonstrated that exosomal miR-30d-5p from PMNs contributed to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis through activating NF-kappa B signaling. These findings suggest a novel mechanism of PMN-M phi interaction in sepsis-related ALI, which may provide new therapeutic strategies in sepsis patients.

CRITICAL CARE (2021)

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Review Biochemistry & Molecular Biology

Inflammasomes as therapeutic targets in human diseases

Yangxin Li et al.

Summary: Inflammasomes, as protein complexes in the innate immune system, play a dual role in diseases, with outcomes that can be either beneficial or detrimental depending on the disease and genetic background. The concept of inflammasome memory and the two-shot activation process are highlighted, along with the proposed M- and N-type inflammation models for targeting the inflammasome pathway in novel therapy development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer

Honglin Yan et al.

Summary: The study revealed that cisplatin induces pyroptosis in triple-negative breast cancer cells through activation of the MEG3/NLRP3/caspase-1/GSDMD pathway, leading to its anti-tumor effects. This finding may contribute to the development of new therapeutic strategies for TNBC.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Polymer Science

AIE polymers: Synthesis and applications

Rong Hu et al.

PROGRESS IN POLYMER SCIENCE (2020)

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Review Chemistry, Multidisciplinary

Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

Xin Yi Wong et al.

ACS NANO (2020)

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Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang et al.

CELL (2020)

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Review Gastroenterology & Hepatology

Recent advances in chemotherapy for pancreatic cancer: evidence from Japan and recommendations in guidelines

Takuji Okusaka et al.

JOURNAL OF GASTROENTEROLOGY (2020)

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Review Engineering, Biomedical

Advances in nanomaterials for photodynamic therapy applications: Status and challenges

Jianming Chen et al.

BIOMATERIALS (2020)

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Article Medicine, Research & Experimental

A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy

Balamayoora Theivanthiran et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Oncology

Enteral tube administration of oral chemotherapy drugs

Samantha H. Spencer et al.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2020)

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Article Cell Biology

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

Lei Hu et al.

CELL DEATH & DISEASE (2020)

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Article Biochemistry & Molecular Biology

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

Yifan Jia et al.

REDOX BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Quantitative Photoacoustic Diagnosis and Precise Treatment of Inflammation In Vivo Using Activatable Theranostic Nanoprobe

Jiamin Ye et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Immunology

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

Sampsa Matikainen et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment

Hongjuan Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

Pengfei Zhao et al.

BIOMATERIALS (2020)

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Editorial Material Chemistry, Multidisciplinary

Transformational Impact of Nanomedicine: Reconciling Outcome with Promise

Andre E. Nel

NANO LETTERS (2020)

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Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Engineering Living Mitochondria with AIE Photosensitizer for Synergistic Cancer Cell Ablation

Jingjing Liu et al.

NANO LETTERS (2020)

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Article Cell Biology

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Junwei Hou et al.

NATURE CELL BIOLOGY (2020)

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Article Clinical Neurology

Chemotherapy for the Management of Cerebral Metastases

Chase H. Foster et al.

NEUROSURGERY CLINICS OF NORTH AMERICA (2020)

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Article Medical Laboratory Technology

Pyroptosis: A pro-inflammatory type of cell death in cardiovascular disease

Qun Wang et al.

CLINICA CHIMICA ACTA (2020)

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Review Cell Biology

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

Mingxia Jiang et al.

CELL DEATH DISCOVERY (2020)

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Article Multidisciplinary Sciences

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Benjamin Demarco et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy

Xiaomei Lu et al.

RSC ADVANCES (2020)

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Article Biochemistry & Molecular Biology

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Nathalia M. de Vasconcelos et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Biochemistry & Molecular Biology

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

Cheng-cheng Zhang et al.

APOPTOSIS (2019)

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Review Immunology

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

Shuo Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Chemistry, Multidisciplinary

Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications

Andres Garcia-Sampedro et al.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES (2019)

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Article Endocrinology & Metabolism

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

Zhen Qiu et al.

JOURNAL OF DIABETES RESEARCH (2019)

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Editorial Material Multidisciplinary Sciences

Precise design of nanomedicines: perspectives for cancer treatment

Jing Wang et al.

NATIONAL SCIENCE REVIEW (2019)

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Article Cell Biology

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway

Yang-Shuo Tang et al.

INFLAMMATION RESEARCH (2019)

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Article Oncology

Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma

Jing Cui et al.

NEURO-ONCOLOGY (2019)

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Article Cell Biology

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

Lingbin Sun et al.

CELL DEATH & DISEASE (2019)

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Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

Xiaojing Xia et al.

CELL DEATH & DISEASE (2019)

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Article Chemistry, Multidisciplinary

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

Jin-Xuan Fan et al.

NANO LETTERS (2019)

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Article Multidisciplinary Sciences

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Melanie Fritsch et al.

NATURE (2019)

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Review Immunology

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

Yansong Xue et al.

TRENDS IN IMMUNOLOGY (2019)

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Article Nanoscience & Nanotechnology

A Strategy of Killing Three Birds with One Stone for Cancer Therapy through Regulating the Tumor Microenvironment by H2O2-Responsive Gene Delivery System

Huapan Fang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Cell Biology

Role of pyroptosis in cardiovascular disease

Zeng Zhaolin et al.

CELL PROLIFERATION (2019)

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Review Geriatrics & Gerontology

Pyroptosis in Liver Disease: New Insights into Disease Mechanisms

Jiali Wu et al.

AGING AND DISEASE (2019)

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Article Biochemistry & Molecular Biology

Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment

Jian Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Medicine, Research & Experimental

Photodynamic therapy - mechanisms, photosensitizers and combinations

Stanislaw Kwiatkowski et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Medical Laboratory Technology

Pyroptosis and its relationship to atherosclerosis

Yuan-Jun Xu et al.

CLINICA CHIMICA ACTA (2018)

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Article Materials Science, Multidisciplinary

Nanoplumbers: biomaterials to fight cardiovascular diseases

Flavio Dormont et al.

MATERIALS TODAY (2018)

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Review Chemistry, Multidisciplinary

Recent advances in functional nanomaterials for light-triggered cancer therapy

Shili Gai et al.

NANO TODAY (2018)

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Article Multidisciplinary Sciences

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

Brienne A. McKenzie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Immunology

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

Tao Gong et al.

TRENDS IN IMMUNOLOGY (2018)

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Review Biochemistry & Molecular Biology

Beyond Cell Death: New Functions for TNF Family Cytokines in Autoimmunity and Tumor Immunotherapy

Fei Yi et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Article Immunology

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

Qingling Guo et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

Stefano Toldo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

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Review Chemistry, Multidisciplinary

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Si-Yong Qin et al.

SMALL (2018)

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Article Multidisciplinary Sciences

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Joseph Sarhan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death

Pontus Orning et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Sebastian Ruhl et al.

SCIENCE (2018)

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Article Medicine, Research & Experimental

Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

Kwong Tai Cheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Chemistry, Multidisciplinary

Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach

Hyo Sung Jung et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

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Review Biochemistry & Molecular Biology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

Jianjin Shi et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

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Review Cell Biology

Gasdermins: Effectors of Pyroptosis

Stephen B. Kovacs et al.

TRENDS IN CELL BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

Vijay A. K. Rathinam et al.

CELL (2016)

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Editorial Material Biochemistry & Molecular Biology

Pyroptosis

Lieselotte Vande Walle et al.

CURRENT BIOLOGY (2016)

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Review Pharmacology & Pharmacy

Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials

Eun Ji Hong et al.

ACTA PHARMACEUTICA SINICA B (2016)

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Article Immunology

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

Dahai Yang et al.

IMMUNITY (2015)

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Editorial Material Immunology

Pyroptosis: Caspase-11 Unlocks the Gates of Death

Aude de Gassart et al.

IMMUNITY (2015)

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Editorial Material Multidisciplinary Sciences

IMMUNOLOGY Caspase target drives pyroptosis

Petr Broz

NATURE (2015)

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Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

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Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

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Article Gastroenterology & Hepatology

NLRP3 Inflammasome Activation Results in Hepatocyte Pyroptosis, Liver Inflammation, and Fibrosis in Mice

Alexander Wree et al.

HEPATOLOGY (2014)

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Article Multidisciplinary Sciences

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

Jiujiu Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Biochemistry & Molecular Biology

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

V. Sagulenko et al.

CELL DEATH AND DIFFERENTIATION (2013)

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Review Multidisciplinary Sciences

Inflammasomes in health and disease

Till Strowig et al.

NATURE (2012)

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Review Microbiology

Pyroptosis: host cell death and inflammation

Tessa Bergsbaken et al.

NATURE REVIEWS MICROBIOLOGY (2009)

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Letter Biochemistry & Molecular Biology

Pro-inflammatory programmed cell death

BT Cookson et al.

TRENDS IN MICROBIOLOGY (2001)

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