Recent Advances in Organ-on-Chips Integrated with Bioprinting Technologies for Drug Screening

Currently, the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease metabolism investigation. These microfluidic devices attempt to recapitulate the physiological and biological properties of different organs and tissues using human-derived cells. Recently, the synergistic combination of additive manufacturing and microfluidics has shown a promising impact on improving a wide array of biological models. In this review, different methods are classified using bioprinting to achieve the relevant biomimetic models in organ-on-chips, boosting the efficiency of these devices to produce more reliable data for drug investigations. In addition to the tissue models, the influence of additive manufacturing on microfluidic chip fabrication is discussed, and their biomedical applications are reviewed.

Automated summary

Currently, scientists and researchers are developing novel approaches to offer an alternative to animal studies in response to the demand for more reliable drug screening devices. Organ-on-chips, which use microfluidic devices to mimic the physiological and biological properties of different organs and tissues using human-derived cells, have emerged as promising platforms for drug screening and disease metabolism investigation. This review focuses on the application of additive manufacturing and bioprinting to enhance the biomimetic models in organ-on-chips and improve the efficiency of drug investigations. The influence of additive manufacturing on microfluidic chip fabrication and its biomedical applications are also discussed.