☆ 4.7 Article

Metabolic Engineering of Candida glycerinogenes for Sustainable Production of Geraniol

ACS SYNTHETIC BIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Agriculture, Multidisciplinary

Overproduction of Patchoulol in Metabolically Engineered Komagataella phaffii

Guangjuan Luo et al.

Summary: In this study, a high-yield patchoulol-producing strain P6H53 was constructed through systematic engineering studies on Komagataella phaffii. It achieved the highest production to date in a 5 L fermenter, laying a good foundation for the development of K. phaffii as a promising microbial cell for the synthesis of patchoulol and other sesquiterpenes.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

Metabolic engineering of the acid-tolerant yeast Pichia kudriavzevii for efficient L-malic acid production at low pH

Yongyan Xi et al.

Summary: Currently, the biological production of L-malic acid (L-MA) faces challenges due to the generation of waste salts and environmental hazards. In this study, acid-tolerant yeast Pichia kudriavzevii was engineered to efficiently produce L-MA through low pH fermentation. This was achieved by constructing an L-MA-producing strain and fine-tuning metabolic flux. Overexpression of a pyridine nucleotide transhydrogenase from E. coli helped overcome the insufficient NADH supply and further improved L-MA production. The engineered strain achieved a high L-MA yield and productivity, while reducing the need for neutralizing agents.

METABOLIC ENGINEERING (2023)

Add to Collection

Article Multidisciplinary Sciences

Engineering a universal and efficient platform for terpenoid synthesis in yeast

Yongshuo Ma et al.

Summary: By introducing a two-step isopentenol utilization pathway (IUP) in yeast, the native mevalonate pathway can be enhanced, leading to increased production of terpenoids. Furthermore, the IUP supports the synthesis of higher-yield monoterpenes and enables efficient synthesis of di-and tetraterpene precursors, circumventing competition with sterol biosynthesis. This study provides a universal and effective platform for terpenoid synthesis in yeast.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Add to Collection

Article Biochemical Research Methods

Production of Caffeic Acid with Co-fermentation of Xylose and Glucose by Multi-modular Engineering in Candida glycerinogenes

Xi-Hui Wang et al.

Summary: This study presents a metabolic engineering strategy for the biosynthesis of caffeic acid (CA) in Candida glycerinogenes. By optimizing the pathways and increasing carbon flux, a high yielding strain was obtained, achieving a higher CA yield from mixed sugar compared to glucose. This research highlights the advantages of using mixed sugar as a carbon source for the high yield production of CA.

ACS SYNTHETIC BIOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate

Leixia Chu et al.

Summary: In this study, the authors report the bioproduction of aminomethylphosphonate (AMP) and a chemical process for converting AMP to glyphosate. This research provides a green alternative in the production of glyphosate, a widely used herbicide.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Biochemical Research Methods

Tuning Geraniol Biosynthesis via a Novel Decane-Responsive Promoter in Candida glycerinogenes

Cui Zhao et al.

Summary: Geraniol is a valuable monoterpene used in various industries. In this study, Candida glycerinogenes was explored as a host for producing monoterpenoids. Through engineering and the use of a hybrid promoter, the production of geraniol was improved. The developed decane-responsive hybrid promoter provides a useful tool for regulating terpenoid production.

ACS SYNTHETIC BIOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Mitochondrial Engineering of Yarrowia lipolytica for Sustainable Production of a-Bisabolene from Waste Cooking Oil

Kun Zhu et al.

Summary: This study focuses on the metabolic engineering of yeasts to produce terpenoids, specifically α-bisabolene, through the utilization of their mitochondria as subcellular factories. Through various engineering approaches, the researchers were able to achieve high levels of α-bisabolene production, with the highest titer reported in a 5 L bioreactor. This study provides valuable insights into the potential and capability of mitochondrial engineering in yeasts for sustainable and green production of valuable compounds.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2022)

Add to Collection

Article Multidisciplinary Sciences

Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering

Chen Ling et al.

Summary: Efficient muconate production from glucose and xylose has been achieved through adaptive laboratory evolution, metabolic engineering, and rational strain engineering strategies.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Production of Putrescine in Metabolic Engineering Corynebacterium crenatum by Mixed Sugar Fermentation

Fengyu Yang et al.

Summary: In this study, metabolic engineering strategies were designed to significantly enhance putrescine production in Corynebacterium crenatum SYPA. By optimizing the synthetic pathway, regulating gene expression, blocking degradation pathways, and constructing a xylose utilization pathway, the titer of putrescine was greatly increased. The engineered strains also showed the potential to produce putrescine from biomass hydrolysates.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2022)

Add to Collection

Article Multidisciplinary Sciences

Auxin-mediated protein depletion for metabolic engineering in terpene-producing yeast

Zeyu Lu et al.

Summary: Researchers successfully redirected metabolic flux using auxin-mediated protein degradation, boosting production of specific compounds and providing a strategy to decouple growth and production. It demonstrates the potential of this approach for broader metabolic perturbation studies.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

One-Pot Efficient Biosynthesis of 4-Hydroxyphenylacetic Acid and Its Analogues from Lignin-Related p-Coumaric and Ferulic Acids

Mingtao Zhao et al.

Summary: This study successfully promotes the efficient biosynthesis of hydroxyphenylacetic acids by engineering an E. coli strain and developing a one-pot bioconversion strategy using lignin-related acids as starting materials. The study demonstrates a new strategy for the sustainable synthesis of hydroxyphenylacetic acids and provides insights into the utilization of lignocellulosic biomass in the production of high-value compounds.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2021)

Add to Collection

Article Chemistry, Multidisciplinary

High-Titer Glutamic Acid Production from Lignocellulose Using an Engineered Corynebacterium glutamicum with Simultaneous Co-utilization of Xylose and Glucose

Ci Jin et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

Add to Collection

Review Genetics & Heredity

Regulation of Ergosterol Biosynthesis inSaccharomyces cerevisiae

Tania Jorda et al.

GENES (2020)

Add to Collection

Review Biochemical Research Methods

New frontiers: harnessing pivotal advances in microbial engineering for the biosynthesis of plant-derived terpenoids

Michael S. Belcher et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

Add to Collection

Article Agricultural Engineering

Ethanol fermentation from non-detoxified lignocellulose hydrolysate by a multi-stress tolerant yeast Candida glycerinogenes mutant

Meilin Zhao et al.

BIORESOURCE TECHNOLOGY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Monoterpene production by the carotenogenic yeast Rhodosporidium toruloides

Xun Zhuang et al.

MICROBIAL CELL FACTORIES (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Establishment of a transient CRISPR-Cas9 genome editing system in Candida glycerinogenes for co-production of ethanol and xylonic acid

Minyang Zhu et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2019)

Add to Collection

Article Agricultural Engineering

Co-production of 1,2,4-butantriol and ethanol from lignocellulose hydrolysates

Meilin Zhao et al.

BIORESOURCE TECHNOLOGY (2019)

Add to Collection

Article Green & Sustainable Science & Technology

Renewable chemical feedstock supply network design: The case of terpenes

Naoum Tsolakis et al.

JOURNAL OF CLEANER PRODUCTION (2019)

Add to Collection

Article Biochemical Research Methods

Vitamin A Production by Engineered Saccharomyces cerevisiae from Xylose via Two-Phase in Situ Extraction

Liang Sun et al.

ACS SYNTHETIC BIOLOGY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae

Bingyin Peng et al.

METABOLIC ENGINEERING (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Overexpression of Ecm22 improves ergosterol biosynthesis in Saccharomyces cerevisiae

S. -Q. Wang et al.

LETTERS IN APPLIED MICROBIOLOGY (2018)

Add to Collection

Review Biotechnology & Applied Microbiology

Biosynthesis and production of sabinene: current state and perspectives

Yujin Cao et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae

Bingyin Peng et al.

METABOLIC ENGINEERING (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Recent advances in synthetic biology for engineering isoprenoid production in yeast

Claudia E. Vickers et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli

Chen Yang et al.

METABOLIC ENGINEERING (2016)

Add to Collection

Article Multidisciplinary Sciences

Rewriting yeast central carbon metabolism for industrial isoprenoid production

Adam L. Meadows et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2

Huiseon Yang et al.

NATURE COMMUNICATIONS (2015)

Add to Collection

Article Biochemical Research Methods

Engineering Monoterpene Production in Yeast Using a Synthetic Dominant Negative Geranyl Diphosphate Synthase

Codruta Ignea et al.

ACS SYNTHETIC BIOLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Patrick J. Westfall et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Biotechnology & Applied Microbiology

Improved homo l-lactic acid fermentation from xylose by abolishment of the phosphoketolase pathway and enhancement of the pentose phosphate pathway in genetically modified xylose-assimilating Lactococcus lactis

Satoru Shinkawa et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2011)

Add to Collection

Article Biotechnology & Applied Microbiology

Metabolic engineering of Escherichia coli for α-farnesene production

Chonglong Wang et al.

METABOLIC ENGINEERING (2011)

Add to Collection

Review Biochemical Research Methods

Advanced biofuel production in microbes

Pamela P. Peralta-Yahya et al.

BIOTECHNOLOGY JOURNAL (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae:: Similar activation/regulatory domains but different response mechanisms

BSJ Davies et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Add to Collection

Article Cell Biology

Farnesyl diphosphate synthase activity affects ergosterol level and proliferation of yeast Saccharomyces cerevisae

F Karst et al.

CELL BIOLOGY INTERNATIONAL (2004)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast

LJ Wilcox et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Add to Collection

Article Biochemical Research Methods

Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method

KJ Livak et al.

METHODS (2001)

Add to Collection

Article Biochemistry & Molecular Biology

Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae

Å Vik et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.