Related references
Note: Only part of the references are listed.Engineering of Burkholderia thailandensis strain E264 serves as a chassis for expression of complex specialized metabolites
Zong-Jie Wang et al.
FRONTIERS IN MICROBIOLOGY (2022)
antiSMASH 6.0: improving cluster detection and comparison capabilities
Kai Blin et al.
NUCLEIC ACIDS RESEARCH (2021)
Total Synthesis of (-)-Disorazole C1
Luca Lizzadro et al.
ORGANIC LETTERS (2021)
An in vitro platform for engineering and harnessing modular polyketide synthases
Takeshi Miyazawa et al.
NATURE COMMUNICATIONS (2020)
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives
Kei Kudo et al.
NATURE COMMUNICATIONS (2020)
Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues
K. C. Nicolaou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters
Chaoyi Song et al.
NUCLEIC ACIDS RESEARCH (2020)
Evolution and Diversity of Assembly-Line Polyketide Synthases
Aleksandra Nivina et al.
CHEMICAL REVIEWS (2019)
The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein
Drew A. Vander Wood et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2018)
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin
Gregory Menchon et al.
NATURE COMMUNICATIONS (2018)
Total Syntheses of Disorazoles A1 and B1 and Full Structural Elucidation of Disorazole B1
K. C. Nicolaou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Aleksandra Wlodek et al.
NATURE COMMUNICATIONS (2017)
Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides
Lihan Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology
Kira J. Weissman
NATURAL PRODUCT REPORTS (2016)
Biosynthesis of polyketides by trans-AT polyketide synthases
Eric J. N. Helfrich et al.
NATURAL PRODUCT REPORTS (2016)
RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression
Hailong Wang et al.
NATURE PROTOCOLS (2016)
Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering
Qiang Tu et al.
SCIENTIFIC REPORTS (2016)
Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase
Yongjun Zhou et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin
Yongjun Zhou et al.
CHEMISTRY & BIOLOGY (2015)
Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells
Shaoyu Wu et al.
ONCOTARGET (2015)
Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreduction
Shawn K. Piasecki et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2014)
Minimally Invasive Mutagenesis Gives Rise to a Biosynthetic Polyketide Library
Susanna Kushnir et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
Jun Fu et al.
NATURE BIOTECHNOLOGY (2012)
Functionally Distinct Modules Operate Two Consecutive alpha,beta ->beta,gamma Double-Bond Shifts in the Rhizoxin Polyketide Assembly Line
Bjoern Kusebauch et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
The Biosynthetic Logic of Polyketide Diversity
Christian Hertweck
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides
Chad D. Hopkins et al.
NATURAL PRODUCT REPORTS (2009)
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
Tuanh Nguyen et al.
NATURE BIOTECHNOLOGY (2008)
Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family
Jana Moldenhauer et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
Michael A. Fischbach et al.
CHEMICAL REVIEWS (2006)
The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation
R Carvalho et al.
GENE (2005)
Production of the tubulin destabilizer disorazol in Sorangium cellulosum:: Biosynthetic machinery and regulatory genes
M Kopp et al.
CHEMBIOCHEM (2005)
Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells
YA Elnakady et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Total synthesis of (-)-disorazole C1
P Wipf et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)