The prognostic role of C-reactive protein to albumin ratio and anti-MDA5 antibody-positive in idiopathic inflammatory myopathy: a retrospective study

This cohort study aimed to identify the characteristics and risk factors of adult idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD) and further explore the prognostic factors of IIM-ILD. We extracted data regarding 539 patients with laboratory-confirmed idiopathic inflammatory myopathy (IIM) with or without interstitial lung disease (ILD) from the Second Xiangya Hospital of Central South University between January 2016 and December 2021. The regression analysis was conducted to identify the possible risk factors for ILD as well as mortality. Of 539 IIM patients, 343 (64.6%) were diagnosed with IIM-ILD. The median (IQR) baseline neutrophil-to-lymphocyte ratio (NLR), C-reactive protein to albumin ratio (CAR) and ferritin were 4.1371 (2.6994-6.8143), 0.1685 (0.0641-0.5456) and 393.6 (210.6-532.2), respectively. Risk factors associated with IIM-ILD were older age (p = 0.002), arthralgia (p = 0.014), lung infection (p = 0.027), hemoglobin (p = 0.022), high CAR (p = 0.014), anti-aminoacyl-tRNA synthetase (anti-ARS) antibody-positive (p < 0.001), and anti-MDA5 antibody-positive (p < 0.001). The IIM-ILD patients whose age at diagnosis of disease >= 59.5 (HR = 2.673, 95% CI 1.588-4.499, p < 0.001), NLR >= 6.6109 (HR = 2.004, 95% CI 1.193-3.368, p = 0.009), CAR >= 0.2506 (HR = 1.864, 95% CI 1.041-3.339, p = 0.036), ferritin >= 397.68 (HR = 2.451, 95% CI 1.245-4.827, p = 0.009) and anti-MDA5 antibody-positive (HR = 1.928, 95% CI 1.123-3.309, p = 0.017) had a higher mortality rate. High CAR and anti-MDA5 antibody-positive are more likely to be associated with a high mortality rate of IIM-ILD, which can be used as serum biomarkers, especially the CAR, a simple, objective tool to assess the prognosis of IIM.

Automated summary

This cohort study aimed to identify the characteristics and risk factors of IIM-ILD in adults and explore prognostic factors. They analyzed data from 539 patients with confirmed IIM from January 2016 to December 2021. Results showed that 64.6% of IIM patients had IIM-ILD. Risk factors for IIM-ILD included older age, arthralgia, lung infection, hemoglobin, high CAR, anti-ARS antibody-positive, and anti-MDA5 antibody-positive. High CAR and anti-MDA5 antibody-positive were associated with higher mortality rate in IIM-ILD patients.