Integration analysis of miRNA-mRNA expression exploring their potential roles in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is the second common primary hepatic malignancy tumor. In this study, an integrative analysis of differentially expressed genes (DEGs) and miRNAs from the ICC onset and adjacent normal tissues were performed to explore the regulatory roles of miRNA-mRNA interaction. A total of 1018 DEGs and 39 miRNAs were likely involved in ICC pathogenesis, suggesting the changes in cell metabolism in ICC development. The built network indicated that 30 DEGs were regulated by 16 differentially expressed miRNA. The screened DEGs and miRNA together were probably considered the biomarkers of ICC, and their important roles in ICC pathogenesis remain to be elucidated. This study could provide a good basis to uncover the regulatory mechanism of miRNA and mRNAs in ICC pathogenesis.

Automated summary

An integrative analysis of differentially expressed genes (DEGs) and miRNAs from ICC onset and adjacent normal tissues was conducted to explore the regulatory roles of miRNA-mRNA interaction. A total of 1018 DEGs and 39 miRNAs were found to be likely involved in ICC pathogenesis, indicating alterations in cell metabolism during ICC development. The network analysis revealed that 30 DEGs were regulated by 16 differentially expressed miRNAs. The identified DEGs and miRNAs may serve as biomarkers for ICC, highlighting their potential importance in ICC pathogenesis. This study provides a solid foundation for understanding the regulatory mechanism of miRNAs and mRNAs in ICC pathogenesis.