Journal
SCIENTIFIC REPORTS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-023-36705-0
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Microbial infections are currently a widespread disease in hospitals and community health centres and are a major cause of death worldwide. Coumarin linked to thiazoles, pyridines and pyrazoles have been developed and evaluated for their antimicrobial properties against different microorganisms. Some of the prepared coumarins displayed high to moderate activity against the tested microorganisms with respect to the reference drugs, and compound 3 showed equal antimicrobial effect as Ciprofloxacin for Enterobacter cloacae. Compound 12 exhibited the most potent activity against Bacillus pumilis, while compounds 3, 4, and 12 showed remarkable activity against Streptococcus faecalis.
Microbial infections are currently a widespread disease in hospitals and community health centres and are a major cause of death worldwide. In pursuit of searching new antimicrobial agents, coumarin linked to thiazoles, pyridines and pyrazoles have been developed and evaluated for their antimicrobial properties against two Gram + bacteria, two Gram - bacteria as well as two fungi. Some of the prepared coumarins displayed high to moderate activity against the tested microorganisms with respect to the reference drugs. However, compound 3 exhibited antimicrobial effect equal to the reference drug Ciprofloxacin for Gram - baceria Enterobacter cloacae. Compound 12 was found to be the most potent compound against Bacillus pumilis with MIC of 7.69 (& mu;mol/ml). Compounds 3, 4 and 12 showed remarkable activity against Streptococcus faecalis with MIC of 14.34, 3.67 and 15.36 (& mu;mol/ml), respectively. Regarding Escherichia coli, most compounds recorded high to moderate MIC values (4.73-45.46 & mu;mol/ml). Moreover, in case of E. cloacae compound 9 was the most potent compound with MIC value of 22.76 (& mu;mol/ml).
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