Journal
SCIENTIFIC REPORTS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-023-33508-1
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Tissue resident memory (Trm) CD8 T cells infiltrating tumors have tumor antigen-specificity, and their presence is associated with improved outcomes. Tumor implantation generates a Trm niche dependent on antigen presentation by cancer cells. Localization of CD8 T cells to tumor draining lymph nodes is necessary for the subsequent generation of CD103(+) CD8 T cells in tumors, which is CD40L-dependent but independent of CD4 T cells. CD8 T cells can provide their own CD40L for CD103(+) CD8 T cell differentiation. CD40L is required for systemic protection against secondary tumors.
Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically engineered mouse pancreatic tumor models we demonstrate that tumor implantation generates a Trm niche that is dependent on direct antigen presentation by cancer cells. However, we observe that initial CCR7-mediated localization of CD8 T cells to tumor draining lymph nodes is required to subsequently generate CD103(+) CD8 T cells in tumors. We observe that the formation of CD103(+) CD8 T cells in tumors is dependent on CD40L but independent of CD4 T cells, and using mixed chimeras we show that CD8 T cells can provide their own CD40L to permit CD103(+) CD8 T cell differentiation. Finally, we show that CD40L is required to provide systemic protection against secondary tumors. These data suggest that CD103(+) CD8 T cell formation in tumors can occur independent of the two-factor authentication provided by CD4 T cells and highlight CD103(+) CD8 T cells as a distinct differentiation decision from CD4-dependent central memory.
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