4.3 Review

Optimization of Patient Pathway in Heart Failure with Reduced Ejection Fraction and Worsening Heart Failure. Role of Vericiguat

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

Factors associated with non-use and sub-target dosing of medical therapy for heart failure with reduced ejection fraction

Stephen J. Greene et al.

Summary: Factors such as older age, worsening renal function, lower body mass index are associated with non-use and sub-target dosing of medical therapy for heart failure with reduced ejection fraction. Commonly, hyperkalemia and hypotension are associated with sub-target dosing. High-risk groups in need of further studies for improving implementation of available medications and exploring the role of novel therapies.

HEART FAILURE REVIEWS (2022)

Article Medicine, General & Internal

Effectiveness of telemedicine in patients with heart failure according to frailty phenotypes: Insights from the iCOR randomised controlled trial

Sergi Yun et al.

Summary: This study found that a telemedicine-based managed care solution is effective in preventing heart failure events in patients with different frailty phenotypes. It also significantly reduces healthcare costs.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

Review Cardiac & Cardiovascular Systems

A Systematic Review and Network Meta-Analysis of Pharmacological Treatment of Heart Failure With Reduced Ejection Fraction

Jasper Tromp et al.

Summary: This study estimated and compared the aggregate treatment benefit of pharmacological therapy for heart failure with reduced ejection fraction. The results showed that a combination of ARNi, BB, MRA, and SGLT2i was most effective in reducing all-cause death and had similar effects on the composite outcome of cardiovascular death or first hospitalization for HF.

JACC-HEART FAILURE (2022)

Article Medicine, General & Internal

Original Usefulness of telemedicine-based heart failure monitoring according to eHealth literacy' domains: Insights from the iCOR randomized controlled trial

Sergi Yuan et al.

Summary: This study evaluated the effectiveness of a telemedicine-based managed care solution for heart failure patients. The results showed that eHealth-based monitoring tools were effective in preventing heart failure events in the early post-discharge period, regardless of patients' literacy levels and information and communications technology skills.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Paul A. Heidenreich et al.

Summary: This article provides an overview of the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure, including its aim, methods, and structure.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

Editorial Material Cardiac & Cardiovascular Systems

Therapeutic inertia in the pharmacological management of heart failure with reduced ejection fraction

Nicolas Girerd et al.

ESC HEART FAILURE (2022)

Article Pharmacology & Pharmacy

Soluble GC stimulators and activators: Past, present and future

Peter Sandner et al.

Summary: The discovery of soluble GC (sGC) stimulators and sGC activators has provided valuable tools for understanding NO-sGC signaling and has led to new pharmacological opportunities for cardiovascular indications. Approved for pulmonary hypertension and heart failure, these compounds enhance sGC activity independently of NO and have unique therapeutic potential.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Cardiac & Cardiovascular Systems

The prehospital patient pathway and experience of care with acute heart failure: a comparison of two health care systems

Joseph McCambridge et al.

Summary: The study aimed to analyze community management of patients with acute decompensated heart failure (ADHF) prior to admission. It found that a majority of patients did not recognize dyspnoea as a symptom of heart failure, and there were challenges in GP management of HF patients, with barriers including inadequate access to diagnostics and specialist support. The findings suggest a potential for earlier intervention and prevention of hospitalization in ADHF.

ESC HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

The Heart Failure Association Atlas: Heart Failure Epidemiology and Management Statistics 2019

Petar M. Seferovic et al.

Summary: The HFA Atlas survey revealed significant heterogeneity in HF disease burden, management resources, and data quality across ESC member countries, highlighting the importance of a systematic approach to capturing HF statistics for quantifying and addressing inequalities and improvements in care.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial

Carolyn S. P. Lam et al.

Summary: The study demonstrated the safety of Vericiguat in patients with worsening heart failure with reduced ejection fraction, even among subgroups predisposed to hypotension. The efficacy of Vericiguat was consistent regardless of baseline systolic blood pressure.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Cardiac & Cardiovascular Systems

CCS/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care for Heart Failure With Reduced Ejection Fraction

Michael McDonald et al.

Summary: This article provides comprehensive recommendations and practical tips for pharmacologic management of patients with heart failure with reduced ejection fraction (HFrEF), focusing on novel pharmacologic therapies. A new standard of pharmacologic care for HFrEF is defined, emphasizing the integration of prioritized pharmacologic with nonpharmacologic and invasive therapies after diagnosis.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Renal function and the effects of vericiguat in patients with worsening heart failure with reduced ejection fraction: insights from the VICTORIA (Vericiguat Global Study in Subjects with HFrEF) trial

Adriaan A. Voors et al.

Summary: Vericiguat showed beneficial effects on the primary outcome in patients with worsening heart failure, regardless of baseline renal function and subsequent changes. Worsening renal function was associated with worse outcomes, but did not affect the efficacy of vericiguat on the primary outcome.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Review Cardiac & Cardiovascular Systems

Remote monitoring and telemedicine in heart failure: implementation and benefits

Jacopo Francesco Imberti et al.

Summary: Remote monitoring of cardiac implantable electronic devices is recommended as part of heart failure patients' follow-up. Recent findings show that it is useful in early detection of technical issues and arrhythmias, but its effectiveness in reducing mortality and hospitalizations is still uncertain. Proactive implementation and response to remote monitoring data by physicians may lead to better outcomes.

CURRENT CARDIOLOGY REPORTS (2021)

Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Theresa A. McDonagh et al.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event Insights From the VICTORIA Trial

Carolyn S. P. Lam et al.

Summary: This study analyzed patients at different time periods after heart failure hospitalization and found that patients closer to their index heart failure event had a higher risk of cardiovascular death or recurrent heart failure. Vericiguat reduced the risk of the primary outcome in all subgroups and showed a trend of greater benefit with longer time since the heart failure event.

JAMA CARDIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Chronic disease management in heart failure: focus on telemedicine and remote monitoring

Paulino Alvarez et al.

Summary: In the context of the COVID-19 pandemic, barriers to telemedicine have decreased, making virtual visits and telemonitoring strategies more common. Evidence suggests that virtual visits can safely replace in-person visits, with a structured approach recommended. Telemonitoring includes various methods and should be tailored to match the patient's risk profile, with attention to cultural and educational barriers important in preventing disparities in implementation.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

A Review of the Proposed Mechanistic Actions of Sodium Glucose Cotransporter-2 Inhibitors in the Treatment of Heart Failure

Brandon Nightingale

Summary: Diabetes mellitus is a well-known risk factor for heart failure, with rising incidence causing major concerns. Concomitant conditions hinder daily living and promote other diseases. Controlling modifiable risk factors like glycemic control and body mass index is beneficial, but pharmacological options should be considered for realistic management.

CARDIOLOGY RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Mindfulness, Anxiety Symptoms, and Quality of Life in Heart Failure

Kaitlyn Rechenberg et al.

JOURNAL OF CARDIOVASCULAR NURSING (2020)

Article Medicine, General & Internal

Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction

Paul W. Armstrong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Editorial Material Cardiac & Cardiovascular Systems

Risk Profiles in Heart Failure Baseline, Residual, Worsening, and Advanced Heart Failure Risk

Stephen J. Greene et al.

CIRCULATION-HEART FAILURE (2020)

Article Health Care Sciences & Services

Costs and healthcare utilisation of patients with heart failure in Spain

Carlos Escobar et al.

BMC HEALTH SERVICES RESEARCH (2020)

Article Medicine, General & Internal

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

Milton Packer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Study design of Heart failure Events reduction with Remote Monitoring and eHealth Support (HERMeS)

Sergi Yun et al.

ESC HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

N-Terminal Pro-B-Type Natriuretic Peptide and Clinical Outcomes

Justin A. Ezekowitz et al.

JACC-HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Clinical Course of Patients With Worsening Heart Failure With Reduced Ejection Fraction

Javed Butler et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Medicine, General & Internal

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

J. J. V. McMurray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Medicine, General & Internal

Disease management interventions for heart failure

Andrea Takeda et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2019)

Review Cardiac & Cardiovascular Systems

Outpatient Worsening Heart Failure as a Target for Therapy A Review

Stephen J. Greene et al.

JAMA CARDIOLOGY (2018)

Article Medicine, General & Internal

Pathophysiologic Mechanisms in Heart Failure: Role of the Sympathetic Nervous System

Steve Antoine et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2017)

Article Cardiac & Cardiovascular Systems

Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition

Scott A. Hubers et al.

CIRCULATION (2016)

Article Cardiac & Cardiovascular Systems

Medical resource use and expenditure in patients with chronic heart failure: a population-based analysis of 88 195 patients

Nuria Farre et al.

EUROPEAN JOURNAL OF HEART FAILURE (2016)

Editorial Material Cardiac & Cardiovascular Systems

Quality Improvement Strategy of the Spanish Society of Cardiology The RECALCAR Registry

Luis Rodriguez-Padial et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Efficacy of Sacubitril/Valsartan Relative to a Prior Decompensation The PARADIGM-HF Trial

Scott D. Solomon et al.

JACC-HEART FAILURE (2016)

Article Cardiac & Cardiovascular Systems

The Renin-Angiotensin-Aldosterone System and Heart Failure

Gabriel Sayer et al.

CARDIOLOGY CLINICS (2014)

Article Medicine, General & Internal

Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure

John J. V. McMurray et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Cardiac & Cardiovascular Systems

Efficacy of an Integrated Hospital-primary Care Program for Heart Failure: A Population-based Analysis of 56 742 Patients

Josep Comin-Colet et al.

REVISTA ESPANOLA DE CARDIOLOGIA (2014)

Review Medicine, General & Internal

Clinical service organisation for heart failure

Andrea Takeda et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2012)

Article Cardiac & Cardiovascular Systems

Repeated hospitalizations predict mortality in the community population with heart failure

Soko Setoguchi et al.

AMERICAN HEART JOURNAL (2007)