The Role of Gasdermin-D-Mediated Pryoptosis in Organ Injury and Its Therapeutic Implications

Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems.

Automated summary

Gasdermin-D (GSDMD) is a pore-forming effector protein that belongs to the Gasdermin family (GSDM). It facilitates inflammatory cell death, also known as pyroptosis. Pyroptosis is dependent on inflammatory caspase activation, which cleaves GSDMD to form membrane pores and release pro-inflammatory cytokines. GSDMD plays a crucial role in immune regulation and homeostasis in various organ systems. This review summarizes its role in pyroptosis-mediated cellular and organ injury, and discusses the potential therapeutic targets of GSDMD in different organ systems.