Urinary C-Peptide to Creatinine Ratio (UCPCR) as Indicator for Metabolic Risk in Apparently Healthy Adults-A BioPersMed Cohort Study

Article Pediatrics

Urinary C-peptide and urinary C-peptide creatinine ratio as markers for insulin resistance in obese children and adolescents

Ahmed Arafa Hassan et al.

Summary: UCP and UCPCR are promising surrogate markers of insulin resistance in children and adolescents with obesity. UCPCR is a better marker than UCP for diagnosing insulin resistance.

PEDIATRIC RESEARCH (2022)

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Article Medicine, General & Internal

Cohort profile: 'Biomarkers of Personalised Medicine' (BioPersMed): a single-centre prospective observational cohort study in Graz/Austria to evaluate novel biomarkers in cardiovascular and metabolic diseases

Christoph Walter Haudum et al.

Summary: The BioPersMed Study is a personalized medicine biomarker study focusing on cardiovascular, endocrine, and metabolic diseases. It aims to evaluate the predictive impact of various biomarkers on the risk of cardiovascular and metabolic diseases.

BMJ OPEN (2022)

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Article Endocrinology & Metabolism

Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function

Wan Zhou et al.

Summary: UCPCR can be used to evaluate islets beta Cell function in T2DM patients with different renal function status. Patients with eGFR>60 ml center dot min(-1)center dot 1.73 m(-2) showed increased levels of UCPCR, FCP, modified HOMA-IR(CP), and HOMA-islet (CP-DM), as well as decreased concentrations of HbA1C, FPG, and creatinine. It was found that UCPCR was positively correlated with FCP and HOMA-IR(CP) in T2DM patients with different levels of renal function, and a cut-off value of UCPCR <= 1.13 nmol/g had high sensitivity and specificity for identifying severe insulin deficiency in these patients.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Endocrinology & Metabolism

Urinary C-peptide/creatinine ratio: A useful biomarker of insulin resistance and refined classification of type 2 diabetes mellitus

Yanai Wang et al.

Summary: This study found that in patients with type 2 diabetes mellitus, UCPCR is positively correlated with insulin resistance, diabetic kidney disease, and coronary heart disease. Including UCPCR could help refine the classification of different subgroups within type 2 diabetes mellitus.

JOURNAL OF DIABETES (2021)

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Article Pediatrics