Effect of Curcumin Consumption on Inflammation and Oxidative Stress in Patients on Hemodialysis: A Literature Review

Advanced chronic kidney disease (CKD) stages lead to exacerbated inflammation and oxidative stress. Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy is inefficient in controlling inflammation. Regular curcumin consumption has been shown to reduce inflammation and oxidative stress in subjects with chronic pathologies, suggesting that the daily intake of curcumin may alleviate these conditions in HD patients. This review analyzes the available scientific evidence regarding the effect of curcumin intake on oxidative stress and inflammation in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. The inclusion of curcumin as a dietary therapeutic supplement in HD patients has shown to control the inflammation status. However, the optimal dose and oral vehicle for curcumin administration are yet to be determined. It is important to consider studies on curcumin bioaccessibility to design effective oral administration vehicles. This information will contribute to the achievement of future nutritional interventions that validate the efficacy of curcumin supplementation as part of diet therapy in HD.

Automated summary

Advanced chronic kidney disease (CKD) stages lead to increased inflammation and oxidative stress. Renal hemodialysis (HD) is not efficient in controlling inflammation in stage 5 CKD patients. However, regular curcumin consumption has been shown to reduce inflammation and oxidative stress in chronic disease patients, suggesting its potential benefits for HD patients. This review examines the effects of curcumin intake on inflammation and oxidative stress in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. While including curcumin as a dietary supplement has shown to control inflammation in HD patients, the optimal dosage and administration method are still uncertain. Further research on curcumin bioaccessibility is needed to design effective oral administration vehicles. This information will contribute to future nutritional interventions that evaluate the efficacy of curcumin supplementation in HD diet therapy.