Journal
NUTRIENTS
Volume 15, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/nu15051201
Keywords
sleeve gastrectomy; fat mass; lean tissue mass; visceral adipose tissue; IGF-1; IGFBP-3; resting energy expenditure; c-reactive protein; Hba1c; HOMA
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This longitudinal study aimed to analyze the changes in body composition (BC) following sleeve gastrectomy (SG) and its effects on glucose, lipids, inflammation, and resting energy expenditure (REE). The study found that after 1 month, losses of lean tissue mass (LTM) and fat mass (FM) were comparable, but at 12 months, the loss of FM exceeded that of LTM. VAT also decreased significantly over this period, and biological parameters normalized while REE was reduced. Beyond 12 months, there were no substantial variations in most BC, biological, and metabolic parameters.
Sleeve gastrectomy (SG) induces weight loss but its effects on body composition (BC) are less well known. The aims of this longitudinal study were to analyse the BC changes from the acute phase up to weight stabilization following SG. Variations in the biological parameters related to glucose, lipids, inflammation, and resting energy expenditure (REE) were concomitantly analysed. Fat mass (FM), lean tissue mass (LTM), and visceral adipose tissue (VAT) were determined by dual-energy X-ray absorptiometry in 83 obese patients (75.9% women) before SG and 1, 12 and 24 months later. After 1 month, LTM and FM losses were comparable, whereas at 12 months the loss of FM exceeded that of LTM. Over this period, VAT also decreased significantly, biological parameters became normalized, and REE was reduced. For most of the BC, biological and metabolic parameters, no substantial variation was demonstrated beyond 12 months. In summary, SG induced a modification in BC changes during the first 12 months following SG. Although the significant LTM loss was not associated with an increase in sarcopenia prevalence, the preservation of LTM might have limited the reduction in REE, which is a longer-term weight-regain criterion.
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