Journal
NUTRIENTS
Volume 15, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nu15061402
Keywords
term infant; gut microbiota; probiotics; Bifidobacterium longum subsp; Infantis; GI motility; short-chain fatty acids; secretory IgA
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Supplementation with Bifidobacterium longum subsp. infantis (B. infantis) M-63 in healthy term infants leads to an increase in beneficial bacteria, a decrease in stool pH, and an increase in acetic acid and IgA levels. It also reduces the frequency of defecation and watery stools. This study highlights the importance of early supplementation with B. infantis M-63 in the development of gut microbiota in infants.
Bifidobacteria are important intestinal bacteria that provide a variety of health benefits in infants. We investigated the efficacy and safety of Bifidobacterium longum subsp. infantis (B. infantis) M-63 in healthy infants in a double-blind, randomized, placebo-controlled trial. Healthy term infants were given B. infantis M-63 (n = 56; 1 x 10(9) CFU/day) or placebo (n = 54) from postnatal age <= 7 days to 3 months. Fecal samples were collected, and fecal microbiota, stool pH, short-chain fatty acids, and immune substances were analyzed. Supplementation with B. infantis M-63 significantly increased the relative abundance of Bifidobacterium compared with the placebo group, with a positive correlation with the frequency of breastfeeding. Supplementation with B. infantis M-63 led to decreased stool pH and increased levels of acetic acid and IgA in the stool at 1 month of age compared with the placebo group. There was a decreased frequency of defecation and watery stools in the probiotic group. No adverse events related to test foods were observed. These results indicate that early supplementation with B. infantis M-63 is well tolerated and contributes to the development of Bifidobacterium-predominant gut microbiota during a critical developmental phase in term infants.
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