Ebola virus disease (EVD) outbreak re-emergence regulation in East Africa: preparedness and vaccination perspective

Editorial Material Infectious Diseases

Ebola vaccines for mass immunisation in affected regions Comment

Selidji Todagbe Agnandji et al.

LANCET INFECTIOUS DISEASES (2022)

Article Virology

The road to effective and accessible antibody therapies against Ebola virus

Hugues Fausther-Bovendo et al.

Summary: Ebola virus outbreaks are highly damaging and effective vaccines and treatments are needed. Although monoclonal antibody therapy has shown promise, survival rates for individuals with high viral load are still low and immunotherapies for other Ebola virus species are in pre-clinical development. The high cost of immunotherapies also limits their accessibility. Novel manufacturing and administration strategies could significantly reduce the cost of immunotherapies, making them valuable tools against Ebola virus and other infectious agents.

CURRENT OPINION IN VIROLOGY (2022)

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Article Pharmacology & Pharmacy

Recent developments and strategies of Ebola virus vaccines

Ashish Ranjan Sharma et al.

Summary: The highly infectious pathogen Ebola virus (EBOV) is responsible for viral hemorrhagic fever, with a fatality rate of 50%-90% in primates. Efforts are being made to develop various vaccine candidates against EBOV, including replicative and non-replicative vectored vaccines, polyepitopic or monovalent vaccines, and DNA vaccines. Continuous research on vaccine development progress may lead to the discovery of more potent and effective vaccine candidates against EBOV.

CURRENT OPINION IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Vaccine development for emerging infectious diseases

Jean-Louis Excler et al.

Summary: Studies on COVID-19 vaccination strategies in comparison to previous infectious diseases offer critical lessons for future public health emergencies. The unprecedented scale and rapid spread of emerging infectious diseases present new challenges for vaccine development and distribution. Prioritizing access to vaccines in low- and middle-income countries, along with close monitoring of vaccine safety and virus variants, will be crucial for the success of pandemic control efforts.

NATURE MEDICINE (2021)

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Review Medicine, General & Internal