Journal
EUROINTERVENTION
Volume 18, Issue 17, Pages 1428-+Publisher
EUROPA EDITION
DOI: 10.4244/EIJ-D-22-00713
Keywords
cerebral protection; clinical research; clinical trials; TAVI
Categories
Ask authors/readers for more resources
The BHF PROTECT-TAVI trial aims to provide definitive evidence on the clinical efficacy and cost-effectiveness of using routine cerebral embolic protection (CEP) with the SENTINEL device to reduce stroke in patients undergoing transcatheter aortic valve implantation (TAVI). The trial has enrolled 3,068 patients out of the total target of 7,730, and the primary outcome is the incidence of stroke at 72 hours post-TAVI.
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis. Cerebral embolic protection (CEP) devices may impact periprocedural stroke by capturing debris destined for the brain. However, there is a lack of high-quality randomised trial evidence supporting the use of CEP during TAVI. The British Heart Foundation (BHF) PROTECT-TAVI trial will address whether the routine use of CEP reduces the incidence of stroke in patients undergoing TAVI. BHF PROTECT-TAVI is a prospective, open-label, outcome-adjudicated, multicentre randomised controlled trial. The trial is open to all adult patients scheduled for TAVI at participating specialist cardiac centres across the United Kingdom who are able to receive the CEP device. The trial will recruit 7,730 participants. Participants will be randomised in a 1:1 ratio to undergo TAVI with CEP or TAVI without CEP (standard of care). The primary outcome is the incidence of stroke at 72 hours post-TAVI. Key secondary outcomes include the incidence of stroke and all-cause mortality up to 12 months post-TAVI, disability and cognitive outcomes, stroke severity, access site complications and a health economics analysis. The sample size of 7,730 participants has 80% power to detect a 33% relative risk reduction from a 3% incidence of the primary outcome in the controls. Trial recruitment commenced in October 2020. As of October 2022, 3,068 patients have been enrolled. BHF PROTECT-TAVI is designed to provide definitive evidence on the clinical efficacy and cost-effectiveness of using routine CEP with the SENTINEL device to reduce stroke in TAVI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available