Journal
ESOPHAGUS
Volume -, Issue -, Pages -Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10388-023-01008-w
Keywords
Achalasia; Chest pain; Dysphagia; Manometry
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This study aimed to explore the relationship between symptom profiles and subtypes of achalasia defined by the Chicago classification. Symptoms of dysphagia and chest pain were evaluated using structured self-reported questionnaires, while esophageal motility was assessed using high-resolution manometry and esophagograms. The results showed that symptom profiles and the location and timing of lesions varied among different subtypes of achalasia, possibly due to the status of the esophageal body.
BackgroundAlthough dysphagia and chest pain are the two most common symptoms in patients with achalasia, the mechanism of evoking symptoms is still unknown. The aim of this study was to reveal the relationship between symptoms and the subtypes of achalasia defined by the Chicago classification.MethodsA total of 71consecutive patients with newly diagnosed achalasia were enrolled between March 2009 and December 2017. Esophageal motility was assessed by high-resolution manometry (HRM) with the Chicago classification v 3.0. and esophagograms. Their symptoms were evaluated with structured self-reported questionnaires focused on dysphagia and chest pain. Symptom profiles and radiographic findings according to the manometric subtypes were investigated.ResultsAmong the total 71 patients, 69 patients (97%) had dysphagia and 39 patients (54%) had chest pain. Regarding dysphagia, type II patients reported dysphagia in the throat the most, while types I and III patients mostly felt it in the epigastrium. Type II patients often felt dysphagia at the time of swallowing (41%), but this was reported in only 8.7% of Type I and 33% of Type III patients (p = 0.02). Concerning chest pain, Type I patients rarely had pain during meals (14%), but more often while sleeping (43%) and in early morning (43%), while type III patients often had pain during meals (67%). Type III patients reported that solid food caused pain more often than other types (I/II/III 0/10/33%, p = 0.09).ConclusionsDetailed symptoms of achalasia, such as its site and timing, varied by subtypes. The status of the esophageal body might induce those differences in symptoms.
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