Related references
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Summary: The presence of epilepsy does not increase susceptibility to COVID-19 infection or mortality related to the infection. However, patients with epilepsy have an increased risk of severe complications after COVID-19 infection, suggesting the need for careful management and monitoring.
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Summary: From March 2020 to October 2021, patients with epilepsy in Bologna had a doubled risk of COVID-19 hospitalization compared to a matched control population, but epilepsy was not a risk factor for COVID-19-related death.
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Summary: In 2020, neurologic involvement was common in children and adolescents hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related complications. This study provides an update on SARS-CoV-2-related neurologic involvement among children and adolescents in 2021. The results show that some patients with neurologic involvement developed life-threatening conditions, and most vaccine-eligible patients were unvaccinated.
Review
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Summary: This systematic review evaluates the characteristics and outcomes of encephalitis in COVID-19 patients. It found that SARS-CoV-2, although primarily infecting the respiratory system, can also affect the central nervous system, causing neurological manifestations such as encephalitis.
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Summary: COVID-19 is associated with increased risks of neurological and psychiatric sequelae. The duration of these risks, their impact on children and adults, and the differences in risk profiles among SARS-CoV-2 variants remain unclear. A 2-year retrospective cohort study analyzed data from electronic health records of COVID-19 patients and found that the risk trajectories differed based on age and outcome. While the risk of mood and anxiety disorders returned to baseline after 1-2 months, the risks of cognitive deficit, dementia, psychotic disorders, and epilepsy or seizures remained increased at the end of the 2-year follow-up period. Children had a more benign overall profile of psychiatric risk but sustained higher risk for certain diagnoses. The findings highlight the importance of understanding the individual and population-level risks of neurological and psychiatric disorders after SARS-CoV-2 infection.
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Summary: This study found that 13.5% of COVID-19 patients developed new neurologic disorders, which were associated with increased risk of in-hospital mortality and decreased likelihood of discharge home.
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