Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial

BackgroundObesity remains a public health problem worldwide. The high prevalence of this condition in the population raises further concerns, considering that comorbidities are often associated with obesity. Among the comorbidities closely associated with obesity, metabolic syndrome (MS) is particularly important, which potentially increases the risk of manifestation of other disorders, such as the prothrombotic and systemic pro-inflammatory states.MethodsA randomized, controlled clinical trial was performed involving female patients (n = 32) aged between 18 and 65 years, with a clinical diagnosis of MS, with severe obesity undergoing Roux-en-Y gastric bypass (RYGB). The study design followed the Consolidated Standards of Reporting Trials statement (CONSORT). Lipid profile, blood glucose and adipokines (adiponectin, leptin, and resistin) and (cytokines IL-1 beta, IL-6, IL-17, IL-23, and TNF-alpha) in blood plasma samples were evaluated before and six months after RYGB.ResultsPatients undergoing RYGB (BSG) showed a significant improvement from preoperative grade III obesity to postoperative grade I obesity. The results showed that while HDL levels increased, the other parameters showed a significant reduction in their postoperative values when compared not only to the values observed before surgery in the BSG group, but also to the values obtained in the control group (CG). As for systemic inflammatory markers adiponectin, leptin, resistin, IL-1 beta, IL-6, IL-17, IL-23 and TNF- alpha it was observed that the levels of resistin and IL-17 in the second evaluation increased significantly when compared to the levels observed in the first evaluation in the CG. In the BSG group, while the levels of adiponectin increased, the levels of the other markers showed significant reductions in the postoperative period, in relation to the respective preoperative levels. The analysis of Spearman's correlation coefficient showed a significant positive correlation between IL-17 and IL-23 in the preoperative period, significant positive correlations between TNF-alpha and IL-6, TNF-alpha and IL-17, IL-6 and IL-17, and IL-17 and IL-23 were observed postoperatively.ConclusionsAccording to our results, the reduction of anthropometric measurements induced by RYGB, significantly improves not only the plasma biochemical parameters (lipid profile and glycemia), but also the systemic inflammatory status of severely obese patients with MS.Trials registration NCT02409160

Automated summary

This study conducted Roux-en-Y gastric bypass surgery on 32 severely obese women with metabolic syndrome and examined the changes in plasma biochemical parameters and systemic inflammatory status before and after the surgery. The results demonstrated significant improvement in anthropometric measurements and blood biochemical parameters after the surgery, indicating the benefits of Roux-en-Y gastric bypass surgery for severely obese patients.