☆ 4.4 Article

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2023)

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo

Lili Cui et al.

Summary: Researchers observed a significant improvement in mRNA functional delivery in vivo by automated LNPs compared to LNPs prepared using traditional microfluidics techniques. The data suggest that the mRNA loading per particle is a critical factor in enhancing mRNA functional delivery of automated LNPs.

SMALL (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Nahal Habibi et al.

Summary: This review summarizes recent trends in the preparation, application, and chemical construction of protein nanoparticles, with a particular focus on their potential breakthroughs in nanomedicine.

ADVANCED SCIENCE (2022)

Add to Collection
Review Pharmacology & Pharmacy

An Overview of Nanotechnologies for Drug Delivery to the Brain

Ahsan Ayub et al.

Summary: Drug delivery to the brain is a challenging task due to the blood-brain barrier. Nanomedicine, which combines nanotechnology, chemistry, and medicine, has shown promising results in improving drug delivery to the brain. Inorganic and organic nanoparticulate systems are being studied for this purpose.

PHARMACEUTICS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Lipid-peptide nanocomplexes for mRNA delivery in vitro and in vivo

Dania Grant-Serroukh et al.

Summary: Despite recent advances in mRNA therapy, the lack of safe and effective delivery vehicles remains a major challenge. In this study, lipid-peptide nanocomplexes were systematically optimized for mRNA delivery. The optimized formulation showed improved transfection efficiency in vitro and in vivo, and retained stable physicochemical properties for a prolonged period of time. This lipid-peptide nanocomplex provides a promising platform for the delivery of therapeutic mRNA.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection
Article Multidisciplinary Sciences

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

Natalie Boehnke et al.

Summary: This study used an integrated genomic approach to investigate the association between cancer cells and nanoparticles, identifying both materials properties and cell-intrinsic features that mediate nanoparticle-cell association. The study also identified nanoparticle-specific biomarkers and validated one biomarker for lipid-based nanoparticle uptake. The findings contribute to the rational design of nanoformulations.

SCIENCE (2022)

Add to Collection
Review Pharmacology & Pharmacy

Nanoparticle entry into cells; the cell biology weak link

Gareth Griffiths et al.

Summary: Nanoparticles are promising for delivering drugs, proteins, and nucleic acids into cells. The development and application of nanoparticles involve scientists from various fields who design, fabricate, and characterize nanoparticles in vitro. However, the research on the interactions between nanoparticles and cells in the field of cell biology is often of sub-standard quality.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection
Review Developmental Biology

Novel approaches for periodontal tissue engineering

W. Benton Swanson et al.

Summary: This review discusses the current state of clinical periodontal regeneration and the potential of growth factors and biomaterial matrices to enhance regeneration. It is important for readers to understand the molecular and cellular processes involved in periodontal regeneration and design comprehensive therapeutic approaches.

GENESIS (2022)

Add to Collection
Article Multidisciplinary Sciences

Imaging flow cytometry

Paul Rees et al.

Summary: Imaging flow cytometry combines the benefits of flow cytometry and microscopy, resulting in rich data sets and novel applications. This paper discusses the instrumentation, data analysis tools, and methods used in imaging flow cytometry, focusing on the ImageStream as an example. It outlines the progression of analysis methods and provides examples of their applications. The paper also discusses the current limitations and innovations in imaging flow cytometry.

NATURE REVIEWS METHODS PRIMERS (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Macropinocytosis as a cell entry route for peptide-functionalized and bystander nanoparticles

Yue-Xuan Li et al.

Summary: The endocytic pathways are crucial for the uptake of nanoparticles into cells and subcellular compartments. Macropinocytosis stands out for its unique ability to engulf large cargo, though its molecular mechanisms and role in nanoparticle uptake are not well understood. This review focuses on the macropinocytic machinery and its involvement in nanoparticle internalization, highlighting the synergistic effect between ligand-functionalized and unfunctionalized nanoparticles. The regulation of nanoparticle uptake efficiency by extracellular amino acids and the interconnectedness of macropinocytosis, metabolism, and nanomedicine are also discussed to inspire future research.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

Joshua J. Rennick et al.

Summary: Endocytosis is crucial for the cellular uptake of therapeutic nanomedicines, but current understanding and study of these mechanisms are limited. The use of nonspecific inhibitors presents challenges, and alternative genetic approaches may offer more robust insights into endocytic pathways. Future studies at the intersection of cell biology and nanomedicine are needed to improve nanoparticle therapies.

NATURE NANOTECHNOLOGY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Caveolae-Mediated Endocytosis Drives Robust siRNA Delivery of Polymeric Nanoparticles to Macrophages

Yudong Song et al.

Summary: Delivery of siRNA into cells remains a challenge, but understanding the cellular uptake and processing of siRNA systems can enhance the development of siRNA-based therapies. Research indicates that caveolae-mediated endocytosis plays a crucial role in efficient siRNA delivery, along with the Golgi complex and endoplasmic reticulum. Additionally, syntaxin6 and Niemann-Pick C1 protein are essential regulators in the delivery of siRNA to macrophages.

ACS NANO (2021)

Add to Collection
Article Chemistry, Physical

It's what's on the inside that counts: Techniques for investigating the uptake and recycling of nanoparticles and proteins in cells

Laura I. FitzGerald et al.

Summary: The review discusses current approaches for measuring the cellular uptake of nanoparticles and proteins, with a focus on recent advances in sensor technology. It highlights the requirements for quantifying internalization and potential pitfalls in data analysis. The importance of understanding recycling of internalized material back to the cell surface and methods for quantifying this process are also explored.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Add to Collection
Review Biochemical Research Methods

The power of imaging to understand extracellular vesicle biology in vivo

Frederik J. Verweij et al.

Summary: Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by virtually every cell type, with diverse biological activities. Recent advances in live and high-resolution microscopy techniques, combined with innovative EV labeling strategies, provide new tools to study EVs in vivo at the single-vesicle level.

NATURE METHODS (2021)

Add to Collection
Article Engineering, Biomedical

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Melissa P. Lokugamage et al.

Summary: This study optimized the design of lipid nanoparticles for the efficient delivery of therapeutic mRNA to the lungs via nebulization, resulting in protection of mice from a lethal challenge of H1N1 influenza A virus and more efficient delivery of mRNA compared to LNPs previously optimized for systemic delivery. The cluster approach to LNP design may facilitate the optimization of LNPs for other administration routes and therapeutics.

NATURE BIOMEDICAL ENGINEERING (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Farshad Moradi Kashkooli et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection
Article Chemistry, Physical

The dose threshold for nanoparticle tumour delivery

Ben Ouyang et al.

NATURE MATERIALS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Efficient Polymer-Mediated Delivery of Gene-Editing Ribonucleoprotein Payloads through Combinatorial Design, Parallelized Experimentation, and Machine Learning

Ramya Kumar et al.

ACS NANO (2020)

Add to Collection
Article Multidisciplinary Sciences

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy

Jason V. Gregory et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

Isabelle M. S. Degors et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Add to Collection
Article Biotechnology & Applied Microbiology

Limits and challenges in using transport inhibitors to characterize how nano-sized drug carriers enter cells

Valentina Francia et al.

NANOMEDICINE (2019)

Add to Collection
Article Cell Biology

Extracellular vesicle measurements with nanoparticle tracking analysis - An accuracy and repeatability comparison between NanoSight NS300 and ZetaView

Daniel Bachurski et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

Add to Collection
Article Chemistry, Analytical

Absolute Quantification of RNA or DNA Using Acid Hydrolysis and Mass Spectrometry

Mark S. Lowenthal et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection
Article Biotechnology & Applied Microbiology

Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway

Hironori Kasai et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Add to Collection
Article Genetics & Heredity

A performance study on three qPCR quantification kits and their compatibilities with the 6-dye DNA profiling systems

Sze-wah Lin et al.

FORENSIC SCIENCE INTERNATIONAL-GENETICS (2018)

Add to Collection
Article Nanoscience & Nanotechnology

Minimum information reporting in bio-nano experimental literature

Matthew Faria et al.

NATURE NANOTECHNOLOGY (2018)

Add to Collection
Article Microscopy

A direct comparison of experimental methods to measure dimensions of synthetic nanoparticles

P. Eaton et al.

ULTRAMICROSCOPY (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Diverse Applications of Nanomedicine

Beatriz Pelaz et al.

ACS NANO (2017)

Add to Collection
Review Chemistry, Multidisciplinary

Nanoengineered Templated Polymer Particles: Navigating the Biological Realm

Jiwei Cui et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Add to Collection
Editorial Material Chemistry, Multidisciplinary

Standardizing Nanomaterials

Paul Mulvaney et al.

ACS NANO (2016)

Add to Collection
Review Chemistry, Multidisciplinary

Increasing the Impact of Materials in and beyond Bio-Nano Science

Mattias Bjornmalm et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Add to Collection
Article Materials Science, Biomaterials

Correlation of particle properties with cytotoxicity and cellular uptake of hydroxyapatite nanoparticles in human gastric cancer cells

Xinhui Cui et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

Add to Collection
Article Biochemical Research Methods

Effect of nucleic acid binding dyes on DNA extraction, amplification, and STR typing

Alicia M. Haines et al.

ELECTROPHORESIS (2015)

Add to Collection
Article Medicine, Research & Experimental

Mechanisms of Nanoparticle Internalization and Transport Across an Intestinal Epithelial Cell Model: Effect of Size and Surface Charge

Azzah M. Bannunah et al.

MOLECULAR PHARMACEUTICS (2014)

Add to Collection
Article Biotechnology & Applied Microbiology

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

Jerome Gilleron et al.

NATURE BIOTECHNOLOGY (2013)

Add to Collection
Letter Nanoscience & Nanotechnology

A tiered approach

Maxine J. McCall et al.

NATURE NANOTECHNOLOGY (2013)

Add to Collection
Article Chemistry, Multidisciplinary

Scavenger Receptor Mediated Endocytosis of Silver Nanoparticles into J774A.1 Macrophages Is Heterogeneous

Hongyun Wang et al.

ACS NANO (2012)

Add to Collection
Review Cell Biology

Imaging Flow Cytometry: Coping with Heterogeneity in Biological Systems

Natasha S. Barteneva et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2012)

Add to Collection
Editorial Material Nanoscience & Nanotechnology

Join the dialogue

[Anonymous]

NATURE NANOTECHNOLOGY (2012)

Add to Collection
Article Nanoscience & Nanotechnology

Focusing the research effort

Francoise Schrurs et al.

NATURE NANOTECHNOLOGY (2012)

Add to Collection
Review Cell Biology

At the Crossroads of Chemistry and Cell Biology: Inhibiting Membrane Traffic by Small Molecules

Lisa von Kleist et al.

TRAFFIC (2012)

Add to Collection
Review Cell Biology

A practical guide to evaluating colocalization in biological microscopy

Kenneth W. Dunn et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Add to Collection
Article Chemistry, Multidisciplinary

Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis

Seiichi Yamano et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Add to Collection
Review Chemistry, Multidisciplinary

How to screen non-viral gene delivery systems in vitro?

Ethlinn V. B. van Gaal et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Add to Collection
Review Chemistry, Multidisciplinary

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

Tore-Geir Iversen et al.

NANO TODAY (2011)

Add to Collection
Review Chemistry, Analytical

Measurement of nanoparticles by light-scattering techniques

Satinder K. Brar et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2011)

Add to Collection
Article Chemistry, Analytical

Comparison of Methods for Accurate Quantification of DNA Mass Concentration with Traceability to the International System of Units

Somanath Bhat et al.

ANALYTICAL CHEMISTRY (2010)

Add to Collection
Review Chemistry, Multidisciplinary

Endocytosis of nanomedicines

Gaurav Sahay et al.

JOURNAL OF CONTROLLED RELEASE (2010)

Add to Collection
Article Medicine, Research & Experimental

Poly(glycoamidoamine) Vehicles Promote pDNA Uptake through Multiple Routes and Efficient Gene Expression via Caveolae-Mediated Endocytosis

Patrick M. McLendon et al.

MOLECULAR PHARMACEUTICS (2010)

Add to Collection
Article Chemistry, Multidisciplinary

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

Vasco Filipe et al.

PHARMACEUTICAL RESEARCH (2010)

Add to Collection
Article Genetics & Heredity

Comparison of five DNA quantification methods

Karsten Nielsen et al.

FORENSIC SCIENCE INTERNATIONAL-GENETICS (2008)

Add to Collection
Article Medical Laboratory Technology

Cellular image analysis and imaging by flow cytometry

David A. Basiji et al.

CLINICS IN LABORATORY MEDICINE (2007)

Add to Collection
Review Biochemistry & Molecular Biology

Modern analytical ultracentrifugation in protein science: A tutorial review

J Lebowitz et al.

PROTEIN SCIENCE (2002)

Add to Collection
Review Biotechnology & Applied Microbiology

Flow cytometry in biotechnology

M Rieseberg et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2001)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.