Cu(II)/polyimide linked COF: An effective mesoporous catalyst for solvent-free 1,5-benzodiazepine synthesis

Copper(II)@polyimide linked covalent organic frameworks (Cu@PI-COF) under solvent-free and microwave assisted conditions have been used in an efficient one-pot protocol for the preparation of 1,5-benzodiazepines via 1,2-diaminobenzene, aromatic aldehydes and dime -done. By applying solvent-free conditions and microwave irradiation, three-component condensa-tion provides safe operations, low pollution, quick access to products, and an easy set-up. As a result of its reusability, the catalyst can also be reutilized many runs without missing any activity.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

Copper(II)@polyimide linked covalent organic frameworks (Cu@PI-COF) were successfully used for the efficient synthesis of 1,5-benzodiazepines via 1,2-diaminobenzene, aromatic aldehydes, and dime-done under solvent-free and microwave assisted conditions. The three-component condensation reaction provides safe operations, low pollution, quick access to products, and an easy setup due to the application of solvent-free conditions and microwave irradiation. The catalyst can be reused multiple times without any loss of activity.