Journal
ACS CATALYSIS
Volume 13, Issue 4, Pages 2696-2701Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c06016
Keywords
tropylium; carbonyl-alkyne metathesis; carbocation; catalysis; alkyne; carbonyl
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The carbonyl-alkyne metathesis (CAM) reaction is a versatile method to access alpha,beta-unsaturated carbonyl compounds, which are important precursors and structural motifs in biologically active substances. We developed an efficient organic Lewis acid catalytic system that promotes both intramolecular and intermolecular CAM reactions. Our metal-free protocol can produce a diverse family of useful organic structures from a broad range of substrates.
The carbonyl-alkyne metathesis (CAM) reaction is a versatile, stereoselective, and atom-economical method to access a diverse range of alpha,beta-unsaturated carbonyl compounds, which are useful synthetic precursors and constitute an important structural motif in biologically active substances. In this work, we developed an efficient organic Lewis acid catalytic system to promote both the intramolecular and intermolecular CAM reactions. This type of versatile catalytic activity has been rarely demonstrated for other established CAM catalysts. Our metal-free protocol was applied to a broad range of substrates to produce a diverse family of useful organic structures.
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