Ongoing movement controls sensory integration in the dorsolateral striatum

The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, sensory responses are affected by motor activity, however, it is not known whether such sensorimotor interactions occur in the striatum and how they are shaped by dopamine. To determine the impact of motor activity on striatal sensory processing, we performed in vivo whole-cell recordings in the DLS of awake mice during the presentation of tactile stimuli. Striatal medium spiny neurons (MSNs) were activated by both whisker stimulation and spontaneous whisking, however, their responses to whisker deflection during ongoing whisking were attenuated. Dopamine depletion reduced the representation of whisking in direct-pathway MSNs, but not in those of the indirect-pathway. Furthermore, dopamine depletion impaired the discrimination between ipsilateral and contralateral sensory stimulation in both direct and indirect pathway MSNs. Our results show that whisking affects sensory responses in DLS and that striatal representation of both processes is dopamine- and cell type-dependent.

Automated summary

This study investigates the influence of motor activity on sensory processing in the dorsolateral striatum (DLS) and how it is modulated by dopamine. Whole-cell recordings in awake mice reveal that whisking affects sensory responses in the DLS, with attenuated responses during ongoing whisking. Dopamine depletion reduces the representation of whisking in direct-pathway neurons and impairs discrimination between ipsilateral and contralateral sensory stimulation in both direct and indirect pathway neurons.