☆ 4.8 Article

Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis

NATURE COMMUNICATIONS (2023)

Related references

Note: Only part of the references are listed.

Review Physiology

Paligenosis: Cellular Remodeling During Tissue Repair

Jeffrey W. Brown et al.

Summary: Multi-cellular organisms utilize cell plasticity rather than unidirectional differentiation to replenish cells, with mechanisms such as mature cells re-entering the cell cycle to regenerate damaged tissue. While plasticity benefits organisms, it also comes with potential oncogenic risks.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond

James R. Goldenring et al.

Summary: The mucosa of the body of the stomach uses depth-dependent mechanisms to respond to injury, leading to various histopathological changes and potential progression to dysplasia and cancer. This metaplasia process is broadly conserved across tissues and species, involving specific cytokines in facilitating the reprogramming of cells into different types, with implications for diagnostic and clinical purposes.

GASTROENTEROLOGY (2022)

Add to Collection

Article Oncology

Real-world effectiveness of nivolumab in advanced gastric cancer: the DELIVER trial (JACCRO GC-08)

Yoshikazu Takahashi et al.

Summary: This multicenter prospective observational study evaluated the efficacy of nivolumab treatment for advanced gastric cancer, showing comparable survival outcomes with previous clinical trials and revealing the frequency and prognosis of patients with hyperprogressive disease (HPD).

GASTRIC CANCER (2022)

Add to Collection

Article Gastroenterology & Hepatology

Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022

Pedro Pimentel-Nunes et al.

Summary: This guideline provides recommendations for the evaluation and treatment of superficial gastrointestinal lesions. It suggests that experienced endoscopists should use high definition white-light and chromoendoscopy for evaluation and recommends endoscopic submucosal dissection for most lesions. Different treatment approaches are suggested for specific situations. The guideline also provides recommendations for post-resection surveillance and treatment.

ENDOSCOPY (2022)

Add to Collection

Article Multidisciplinary Sciences

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Robert Palovics et al.

Summary: Slowing or reversing biological ageing can have significant implications for disease risk reduction and maintaining vitality. However, there is still much to explore regarding the effectiveness of interventions on various cell types and molecular pathways. Through single-cell RNA sequencing on 20 organs, this study identified specific cell types, such as adipose mesenchymal stromal cells, haematopoietic stem cells, and hepatocytes, that respond to young and aged blood. Additionally, it was found that young blood not only reverses established ageing patterns but also activates new gene sets, particularly highlighting the role of mitochondrial function in rejuvenation.

NATURE (2022)

Add to Collection

Review Gastroenterology & Hepatology

Gastric Organoids: Progress and Remaining Challenges

Min-Jiao Pang et al.

Summary: This article discusses the research on gastric organoids, with a focus on the advantages of culturing human tissues and the use of mouse organoid models. It introduces the methods for culturing healthy gastric tissue and highlights the applications of organoids in drug screening and precision medicine.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Add to Collection

Article Oncology

Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

F. Lordick et al.

ANNALS OF ONCOLOGY (2022)

Add to Collection

Article Oncology

Chemokines and chemokine receptors in colorectal cancer; multifarious roles and clinical impact

Maria Braoudaki et al.

Summary: Colorectal cancer is a common and deadly disease, and early diagnosis is crucial for patient prognosis. However, little progress has been made in identifying biomarkers for early diagnosis, resulting in high mortality rates in advanced stages. This review investigates the role of chemokines and chemokine receptors in colorectal cancer, discusses their potential as personalized therapeutic approaches, and summarizes the progress in drug resistance research.

SEMINARS IN CANCER BIOLOGY (2022)

Add to Collection

Review Oncology

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

Ashton A. Connor et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest epithelial malignancies, with increasing research over several decades leading to a better understanding of its carcinogenesis and significant progress in genomics and transcriptomics. The inclusion of PDAC data in international pan-cancer analyses has provided further insights, and the study of PDAC evolution and heterogeneity has led to the proposal of an evolutionary model based on genomics studies of human PDAC.

NATURE REVIEWS CANCER (2022)

Add to Collection

Article Gastroenterology & Hepatology

DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia

Zhi-Feng Miao et al.

Summary: The study reveals that high expression of DDIT4 in gastric chief cells decreases as cells become metaplastic. DDIT4 deficiency leads to increased mTORC1 levels, exacerbating mitosis of metaplastic cells and tumor formation.

GASTROENTEROLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Non-duplex G-Quadruplex DNA Structure: A Developing Story from Predicted Sequences to DNA Structure-Dependent Epigenetics and Beyond

Antara Sengupta et al.

Summary: The study of G-quadruplex (G4) DNA has evolved from initial skepticism to great interest, with multiple laboratories including ours contributing to advancements in understanding its gene regulatory and epigenetic functions. The research on G4 structures has provided a broad perspective on their prevalence and significance, shedding light on their potential impact in gene regulation and epigenetic modifications.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

Add to Collection

Article Cell Biology

Autophagy repurposes cells during paligenosis

Zhi-Feng Miao et al.

Summary: Differentiated cells have evolved a conserved program called paligenosis to return to a stem or progenitor state and reenter the cell cycle for tissue repair. Key regulators of paligenosis, such as Ddit4 and Ifrd1, control different stages of the process, providing potential new insights for tissue regeneration and cancer therapy.

AUTOPHAGY (2021)

Add to Collection

Article Oncology

Immunometabolic Interplay in the Tumor Microenvironment

Irem Kaymak et al.

Summary: The study discusses the metabolic characteristics of immune cells in the tumor microenvironment and proposes future research directions.

CANCER CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Yunfan Sun et al.

Summary: This study showed that early-relapse hepatocellular carcinoma (HCC) tumors exhibit innate-like CD8(+) T cells with overexpression of KLRB1 (CD161) and a low cytotoxic state, unlike the exhausted state seen in primary HCC. These cells were associated with a worse prognosis. Additionally, potential immune evasion mechanisms were identified in recurrent tumor cells, which dampen dendritic cell antigen presentation and recruit innate-like CD8(+) T cells.

CELL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine

Therese Seidlitz et al.

Summary: Gastric cancer is a common and deadly malignancy with late clinical manifestation and poor survival rates. Patient-derived organoids offer new perspectives for translational clinical applications by allowing in-depth analysis of tissue-specific functions, development, and disease.

CELL DEATH AND DIFFERENTIATION (2021)

Add to Collection

Article Gastroenterology & Hepatology

Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition)

Hiroyuki Ono et al.

Summary: In response to the rapid development in endoscopic treatments for early gastric cancer, the Japan Gastroenterological Endoscopy Society collaborated with the Japanese Gastric Cancer Association to produce guidelines in 2014. The revised second edition covers seven categories to provide a comprehensive overview of knowledge in the field.

DIGESTIVE ENDOSCOPY (2021)

Add to Collection

Article Oncology

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

Yuanyuan Zhang et al.

Summary: The study indicates that high levels of baseline CXCL13(+) T cells are associated with effective responses to combination therapy in triple-negative breast cancer patients. These cells increase following combination therapy but decrease after monotherapy, highlighting their importance in predicting treatment outcomes.

CANCER CELL (2021)

Add to Collection

Article Oncology

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

Lewis Au et al.

Summary: The ADAPTeR study aimed to investigate the mechanism of therapeutic response to nivolumab in metastatic clear cell renal cell carcinoma, with genomic analysis showing no correlation between tumor molecular features and response. Pre-existing immunity may play a key role in predicting clinical response.

CANCER CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

Ruiping Wang et al.

Summary: The study investigated intratumoral heterogeneity (ITH) in peritoneal carcinomatosis of gastric cancer patients through single-cell transcriptome profiling, revealing significant correlations between ITH and patient survival. By analyzing the diversity in tumor cell lineage/state compositions, researchers identified a prognostic signature that could be practical for patient stratification.

NATURE MEDICINE (2021)

Add to Collection

Article Oncology

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

Kevin Bi et al.

Summary: The study shows that immune checkpoint blockade (ICB) remodels the RCC microenvironment and modifies the interplay between cancer and immune cell populations, critical for understanding response and resistance to ICB.

CANCER CELL (2021)

Add to Collection

Review Oncology

Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment

Varun Sasidharan Nair et al.

Summary: Metabolic dysregulation in the hypoxic tumor microenvironment plays a crucial role in the development of solid tumors, particularly in the metabolic reprogramming of Tregs. This reprogramming can affect the biological properties of Tregs, increasing their presence and proliferation within the TME. Understanding and regulating the metabolism of Tregs may have important implications for the treatment of tumors.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Xianwen Ren et al.

Summary: The study revealed the presence of immune response dysfunction in COVID-19 patients, with different peripheral immune subtype changes associated with clinical features such as age, sex, severity, and disease stages. Additionally, dramatic transcriptomic changes were observed within virus-infected cells, and upregulation of S100A8/A9 in peripheral blood may contribute to the cytokine storms frequently observed in severe patients.

CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Sijin Cheng et al.

Summary: This study conducted a pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types, revealing distinct features of TIMs in different cancer types. For example, mast cells in nasopharyngeal cancer were associated with better prognosis, and pro-angiogenic TAMs showed diverse markers across different cancer types. The composition of TIMs appeared to be linked with certain features of somatic mutations and gene expressions.

CELL (2021)

Add to Collection

Review Cell & Tissue Engineering

Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors

Courtney L. Jones et al.

Summary: The article explores the significance of malignant stem cells in leukemia and how targeting energy metabolism can offer more effective treatment options for leukemia patients. It discusses the metabolic properties of leukemia stem cells and compares them with malignant stem cells from solid tumors.

CELL STEM CELL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The cancer metabolic reprogramming and immune response

Longzheng Xia et al.

Summary: The overlapping metabolic reprogramming between cancer and immune cells is an important factor affecting the antitumor immune response, involving metabolic competition, nutrient limitation, and impaired immune cell function. Studies have shown that metabolic reprogramming is essential for maintaining immune cell homeostasis and executing effector functions during immune responses.

MOLECULAR CANCER (2021)

Add to Collection

Article Oncology

A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Miguel F. Sanmamed et al.

Summary: The study has identified a dysfunctional CD8(+) tumor-infiltrating subpopulation that is highly proliferative, overactivated, and apoptotic, distinct from previously described exhausted T cells. This subpopulation expands in lung cancer tissues in a PD-1/B7-H1-dependent manner and its abundance is associated with resistance to cancer immunotherapy, making it a potential tissue biomarker.

CANCER DISCOVERY (2021)

Add to Collection

Article Oncology

Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer

Vikrant Kumar et al.

Cancer Discovery (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of proteins and cellular pathways targeted by 2-nitroimida- zole hypoxic cytotoxins

Faisal Bin Rashed et al.

Summary: Tumour hypoxia negatively impacts therapy outcomes and remains a major clinical challenge. Nitroimidazoles are hypoxia selective compounds with potential as hypoxia-directed therapeutics. A novel 2-nitroimidazole, N-3-AZA, has been shown to reduce enzymatic activities of critical proteins in cancer cells, indicating its potential as a target for nitroimidazole-based cancer therapeutics.

REDOX BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program

Megan D. Radyk et al.

Summary: ATF3 and RAB7B are upregulated in the early Stage 1 of paligenosis to help cells induce autophagic and lysosomal mechanisms. Atf3(-/-) mice fail to induce autophagic and lysosomal vesicles, leading to increased cell death. The evolutionarily conserved ATF3 gene orchestrates early paligenotic autodegradative events.

EMBO REPORTS (2021)

Add to Collection

Article Medicine, Research & Experimental

An explainable supervised machine learning predictor of acute kidney injury after adult deceased donor liver transplantation

Yihan Zhang et al.

Summary: An early prediction model for post-liver transplantation AKI was developed using supervised machine learning, with the GBM model showing the best performance in both internal and external validation sets. The SHAP method identified high preoperative indirect bilirubin, low intraoperative urine output, long anesthesia time, low preoperative platelets, and graft steatosis as the top 5 important variables influencing the diagnosis of post-LT AKI. This GBM-based predictor provides a highly interoperable tool for decision-making after liver transplantation.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Shangce Du et al.

Summary: Anoikis resistance is crucial for the survival of metastatic cancer cells, but the molecular mechanisms are poorly understood. Study found that GC(AR) cells exhibit stronger metastatic and pro-angiogenic traits, promoting GC cell survival and angiogenesis through elevated PDGFB secretion.

ONCOGENE (2021)

Add to Collection

Review Multidisciplinary Sciences

Mapping genomic and epigenomic evolution in cancer ecosystems

Toshikazu Ushijima et al.

Summary: Cancer, driven by genomic and epigenomic derangements, requires multimodal data integration to understand the molecular evolution of malignant cell states across its lifecycle. Driver mutations and epigenetic alterations in normal-appearing tissues prompt a reassessment of cancer initiation, while studying clonal selection, epigenomic adaptation, and persister cells in metastasis and therapy resistance is an emerging field. The importance of tumor ecosystems in cancer development is being unveiled by advancing single-cell and spatial technologies.

SCIENCE (2021)

Add to Collection

Review Oncology

Metabolic Plasticity of Neutrophils: Relevance to Pathogen Responses and Cancer

Thomas Rogers et al.

Summary: The article discusses the role of neutrophils in fighting pathogens and cancer cells, as well as the role of tumor-associated neutrophils (TANs) in tumor development and how targeting TAN metabolism can enhance cancer immunotherapy.

TRENDS IN CANCER (2021)

Add to Collection

Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

Add to Collection

Review Oncology

The Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer

L. Paige Ferguson et al.

Summary: Despite increased knowledge of the intrinsic signals involved in cancer progression, effective clinical management of cancer remains challenging. Drug resistance and relapse, primarily driven by the exploitation of stem cell programs by aggressive cancer cell subpopulations, are major barriers in cancer care. Understanding the niche and signals that sustain cancer stem cells may lead to new strategies in targeting them by disrupting the microenvironmental support.

TRENDS IN CANCER (2021)

Add to Collection

Review Oncology

Cancer stem cell-immune cell crosstalk in tumour progression

Defne Bayik et al.

Summary: The development of tumors is affected by cellular heterogeneity and an immunosuppressive tumor microenvironment, which interact with each other and lead to therapeutic resistance. The interaction between cancer stem cells and infiltrating immune cell populations in the tumor microenvironment promotes tumor development and immune evasion.

NATURE REVIEWS CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

Aleksandar Obradovic et al.

Summary: This study identified specific subpopulations and their master regulators through single-cell RNA sequencing, and found that TREM2/APOE/C1Q-positive macrophage infiltration could serve as a potential prognostic biomarker for ccRCC recurrence.

CELL (2021)

Add to Collection

Review Immunology

Metabolic barriers to cancer immunotherapy

Kristin DePeaux et al.

Summary: The tumour microenvironment creates barriers that suppress immune responses, including physical barriers, recruitment of suppressive immune cells, and upregulation of inhibitory ligands on tumour cells. Therapies targeting metabolic restrictions in the tumour microenvironment show promise for combination therapies against various types of cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

Add to Collection

Review Oncology

Linking EMT programmes to normal and neoplastic epithelial stem cells

Arthur W. Lambert et al.

Summary: Epithelial stem cells play critical roles in tissue generation, maintenance, and repair, while cancer stem cells are implicated in the growth and recurrence of many carcinomas. The activation of epithelial-mesenchymal transition (EMT) is linked to the formation of both normal and neoplastic stem cells, but the mechanistic basis of this connection remains unclear. Understanding the elusive links between EMT programs and the stem cell state will advance our knowledge of normal stem cell biology and cancer pathogenesis.

NATURE REVIEWS CANCER (2021)

Add to Collection

Article Oncology

Prediction of Peritoneal Recurrence in Patients with Gastric Cancer: a Multicenter Study

Tulay Kus et al.

Summary: This study aimed to analyze the risk of peritoneal recurrence in gastric cancer patients treated with adjuvant chemotherapy or chemoradiotherapy after surgery, and developed a new scoring model showing that female gender, T4 tumor stage, undifferentiated histopathology, and signet cell carcinoma type have a higher tendency for peritoneal recurrence. Patients with 3 or 4 risk factors had an 8.8-fold increased risk for peritoneal recurrence.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

Add to Collection

Article Gastroenterology & Hepatology

Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response

Ruiping Wang et al.

GUT (2020)

Add to Collection

Article Biochemical Research Methods

CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes

Mirjana Efremova et al.

NATURE PROTOCOLS (2020)

Add to Collection

Article Oncology

Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2-VEGFA axis

Makoto Natsume et al.

BRITISH JOURNAL OF CANCER (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang et al.

CELL (2020)

Add to Collection

Review Oncology

Lineage plasticity in cancer: a shared pathway of therapeutic resistance

Alvaro Quintanal-Villalonga et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Add to Collection

Article Oncology

Factors Associated with Resection and Survival After Laparoscopic HIPEC for Peritoneal Gastric Cancer Metastasis

Michael G. White et al.

ANNALS OF SURGICAL ONCOLOGY (2020)

Add to Collection

Article Cell Biology

A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

Zhi-Feng Miao et al.

DEVELOPMENTAL CELL (2020)

Add to Collection

Article Oncology

Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma

Rui Dong et al.

CANCER CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

Ashley Maynard et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

A single-cell landscape of high-grade serous ovarian cancer

Benjamin Izar et al.

NATURE MEDICINE (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Discovering Biomarkers in Peritoneal Metastasis of Gastric Cancer by Metabolomics

Guoqiang Pan et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Review Pharmacology & Pharmacy

Molecular Therapeutics of Pancreatic Ductal Adenocarcinoma: Targeted Pathways and the Role of Cancer Stem Cells

Andrei-Florian Stoica et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Add to Collection

Article Immunology

MAIT cell activation and dynamics associated with COVID-19 disease severity

Tiphaine Parrot et al.

SCIENCE IMMUNOLOGY (2020)

Add to Collection

Article Oncology

MIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma

Ricardo A. de Azevedo et al.

ONCOIMMUNOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4

Jan Korbecki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Oncology

Metabolism of immune cells in cancer

Robert D. Leone et al.

NATURE REVIEWS CANCER (2020)

Add to Collection

Article Medicine, Research & Experimental

Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis

Gengtai Ye et al.

THERANOSTICS (2020)

Add to Collection

Article Gastroenterology & Hepatology

Exosomal microRNA in peritoneal fluid as a biomarker of peritoneal metastases from gastric cancer

Hideyuki Ohzawa et al.

ANNALS OF GASTROENTEROLOGICAL SURGERY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Conversion Surgery for Gastric Cancer with Peritoneal Metastasis Based on the Diagnosis of Second-Look Staging Laparoscopy

Masaki Nakamura et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2019)

Add to Collection

Article Oncology

Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases from Gastric Cancer and May Lead to Gastrectomy

Timothy E. Newhook et al.

ANNALS OF SURGICAL ONCOLOGY (2019)

Add to Collection

Review Oncology

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

Jonathan Cooper et al.

CANCER CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

Mikhail Binnewies et al.

CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection

Review Oncology

Cellular Plasticity in Cancer

Salina Yuan et al.

CANCER DISCOVERY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

Christopher S. McGinnis et al.

CELL SYSTEMS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

CELL (2019)

Add to Collection

Article Multidisciplinary Sciences

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

Add to Collection

Article Cell Biology

Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis

Meijun Si et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Add to Collection

Article Immunology

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma

Ashanty M. Melo et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Oncology

Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer

Yanting Hu et al.

CANCER LETTERS (2019)

Add to Collection

Article Immunology

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Charles-Antoine Dutertre et al.

IMMUNITY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

Chrysothemis C. Brown et al.

CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

Qiming Zhang et al.

CELL (2019)

Add to Collection

Article Immunology

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

Eric H. Ma et al.

IMMUNITY (2019)

Add to Collection

Article Biochemical Research Methods

Fast, sensitive and accurate integration of single-cell data with Harmony

Ilya Korsunsky et al.

NATURE METHODS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Hanjie Li et al.

CELL (2019)

Add to Collection

Review Cell & Tissue Engineering

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

Piyush B. Gupta et al.

CELL STEM CELL (2019)

Add to Collection

Review Cell & Tissue Engineering

Cancer Stem Cells: The Architects of the Tumor Ecosystem

Briana C. Prager et al.

CELL STEM CELL (2019)

Add to Collection

Review Cell & Tissue Engineering

Targeting Cancer Stemness in the Clinic: From Hype to Hope

Caner Saygin et al.

CELL STEM CELL (2019)

Add to Collection

Article Immunology

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

Dvir Aran et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Review Immunology

Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity

Martijn J. Schuijs et al.

TRENDS IN IMMUNOLOGY (2019)

Add to Collection

Review Immunology

Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy

Anna E. Vilgelm et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Review Oncology

Phenotype plasticity as enabler of melanoma progression and therapy resistance

Imanol Arozarena et al.

NATURE REVIEWS CANCER (2019)

Add to Collection

Review Immunology

Mucosal-associated invariant T cells and disease

Amine Toubal et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Add to Collection

Article Oncology

Risk of peritoneal metastases in patients who had negative peritoneal staging and received therapy for localized gastric adenocarcinoma

Dilsa Mizrak Kaya et al.

JOURNAL OF SURGICAL ONCOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Elham Azizi et al.

CELL (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis

Spencer G. Willet et al.

EMBO JOURNAL (2018)

Add to Collection

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Xinyi Guo et al.

NATURE MEDICINE (2018)

Add to Collection

Article Multidisciplinary Sciences

The protein histidine phosphatase LHPP is a tumour suppressor

Sravanth K. Hindupur et al.

NATURE (2018)

Add to Collection

Article Oncology

Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus-Derived Vectors Fosters Dendritic Cell-Mediated T-cell Cross-Priming

Alfonso R. Sanchez-Paulete et al.

CANCER RESEARCH (2018)

Add to Collection

Review Cell Biology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

Hugo Gonzalez et al.

GENES & DEVELOPMENT (2018)

Add to Collection

Article Multidisciplinary Sciences

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Lei Zhang et al.

NATURE (2018)

Add to Collection

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Article Gastroenterology & Hepatology

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

Xiaoguang Li et al.

GUT (2017)

Add to Collection

Review Immunology

Tim-3 and its role in regulating anti-tumor immunity

Madhumita Das et al.

IMMUNOLOGICAL REVIEWS (2017)

Add to Collection

Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Cancer stem cells revisited

Eduard Batlle et al.

NATURE MEDICINE (2017)

Add to Collection

Article Biochemical Research Methods

SCENIC: single-cell regulatory network inference and clustering

Sara Aibar et al.

NATURE METHODS (2017)

Add to Collection

Article Biochemical Research Methods

Single-cell mRNA quantification and differential analysis with Census

Xiaojie Qiu et al.

NATURE METHODS (2017)

Add to Collection

Article Biochemical Research Methods

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu et al.

NATURE METHODS (2017)

Add to Collection

Review Oncology

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Tsukasa Shibue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Andrew S. Venteicher et al.

SCIENCE (2017)

Add to Collection

Review Immunology

Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes

Pilar Lopez-Cotarelo et al.

TRENDS IN IMMUNOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

Christopher R. Shaler et al.

PLOS BIOLOGY (2017)

Add to Collection

Review Oncology

Pre-metastatic niches: organ-specific homes for metastases

Hector Peinado et al.

NATURE REVIEWS CANCER (2017)

Add to Collection

Article Oncology

Characteristics and Significance of the Pre-metastatic Niche

Yang Liu et al.

CANCER CELL (2016)

Add to Collection

Article Oncology

Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

Ghaith Bakdash et al.

CANCER RESEARCH (2016)

Add to Collection

Article Immunology

Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

Helene Salmon et al.

IMMUNITY (2016)

Add to Collection

Review Medicine, General & Internal

Gastric cancer

Eric Van Cutsem et al.

LANCET (2016)

Add to Collection

Article Multidisciplinary Sciences

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh et al.

SCIENCE (2016)

Add to Collection

Review Immunology

Dendritic Cells and Cancer Immunity

Alycia Gardner et al.

TRENDS IN IMMUNOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

Edoardo Gaude et al.

NATURE COMMUNICATIONS (2016)

Add to Collection

Article Medicine, General & Internal

Ovarian cancer

Ursula A. Matulonis et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang et al.

CELL (2015)

Add to Collection

Article Gastroenterology & Hepatology

The role of endoscopy in the management of premalignant and malignant conditions of the stomach

John A. Evans et al.

GASTROINTESTINAL ENDOSCOPY (2015)

Add to Collection

Article Mathematical & Computational Biology

PathCards: multi-source consolidation of human biological pathways

Frida Belinky et al.

Database-The Journal of Biological Databases and Curation (2015)

Add to Collection

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Add to Collection

Article Oncology

Preferential HER2 expression in liver metastases and EGFR expression in peritoneal metastases in patients with advanced gastric cancer

Takuya Saito et al.

GASTRIC CANCER (2015)

Add to Collection

Review Immunology

The ins and outs of MHC class II-mediated antigen processing and presentation

Paul A. Roche et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Add to Collection

Review Immunology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Jason W. Griffith et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Add to Collection

Article Oncology

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma

Qing-Min Fan et al.

CANCER LETTERS (2014)

Add to Collection

Article Oncology

VISTA Is an Immune Checkpoint Molecule for Human T Cells

J. Louise Lines et al.

CANCER RESEARCH (2014)

Add to Collection

Article Cell & Tissue Engineering

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

Alexander Pietras et al.

CELL STEM CELL (2014)

Add to Collection

Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

Add to Collection

Review Multidisciplinary Sciences

Metabolism of stromal and immune cells in health and disease

Bart Ghesquiere et al.

NATURE (2014)

Add to Collection

Article Multidisciplinary Sciences

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Joseph T. Rodgers et al.

NATURE (2014)

Add to Collection

Article Multidisciplinary Sciences

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop P. Patel et al.

SCIENCE (2014)

Add to Collection

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Add to Collection

Article Oncology

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

Andrea Casazza et al.

CANCER CELL (2013)

Add to Collection

Article Medicine, Research & Experimental

CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches

Karin Williams et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Add to Collection

Article Immunology

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

Elodie Segura et al.

IMMUNITY (2013)

Add to Collection

Article Oncology

Dendritic Cells: Master Regulators of the Immune Response

Ira Mellman

CANCER IMMUNOLOGY RESEARCH (2013)

Add to Collection

Review Immunology

The Chemokine Superfamily Revisited

Albert Zlotnik et al.

IMMUNITY (2012)

Add to Collection

Article Immunology

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

Muzlifah Haniffa et al.

IMMUNITY (2012)

Add to Collection

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Add to Collection

Article Oncology

Japanese classification of gastric carcinoma: 3rd English edition

GASTRIC CANCER (2011)

Add to Collection

Article Multidisciplinary Sciences

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

Masahisa Jinushi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Add to Collection

Review Oncology

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

Margot Zoeller

NATURE REVIEWS CANCER (2011)

Add to Collection

Article Oncology

Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment

Helena Harlin et al.

CANCER RESEARCH (2009)

Add to Collection

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Add to Collection

Review Oncology

Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment

M Toi et al.

LANCET ONCOLOGY (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.