Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers

A comprehensive evaluation of the total burden of morbidity endured by cancer survivors remains unavailable. This study quantified the burden of 144 health conditions and critical care admissions across 26 adult cancers and treatment modalities in 243,767 adults. By age 60, top conditions ranked by fold difference (cumulative burden in survivors divided by cumulative burden in controls) were haematology, immunology/infection and pulmonary conditions. Patients who had all three forms of treatment (chemotherapy, radiotherapy and surgery) experienced a high cumulative burden of late morbidities compared with patients who received radiotherapy alone. The top five cancers with the highest cumulative burden of critical care admissions by age 60 were bone (12.4 events per 100 individuals [CI: 11.6-13.1]), brain (9.0 [7.5-10.5]), spinal cord and nervous system (7.2 [6.7-7.8]), testis (6.7 [4.9-8.4]) and Hodgkin lymphoma (4.4 [3.6-5.1]). Conditions that were associated with high excess years-of-life-lost were haematological conditions (9.6 years), pulmonary conditions (8.6 years) and immunological conditions or infections (7.8 years). As the population of cancer survivors continues to grow, our results indicate that it is important to tackle long-term health consequences through enacting data-driven policies.

Automated summary

This study evaluated the burden of 144 health conditions and critical care admissions in 243,767 adults with 26 adult cancers and treatment modalities. The top conditions by fold difference in cumulative burden in survivors compared to controls were haematology, immunology/infection, and pulmonary conditions. Patients receiving chemotherapy, radiotherapy, and surgery had a higher burden of late morbidities compared to those receiving radiotherapy alone. The top five cancers with the highest cumulative burden of critical care admissions were bone, brain, spinal cord and nervous system, testis, and Hodgkin lymphoma.