miRNAs as biomarkers of musculoskeletal pain in long-distance runners: the MiMuS study protocol

miRNAs are involved in the generation and progression of musculoskeletal pain, a condition that causes significant clinical, economic and social burden. In runners, the presence of musculoskeletal pain related to an inflammatory state or ongoing underlying tissue damage may result in poor training ability and performance. This study aims to evaluate the association between circulating and salivary miRNAs and pain in runners with and without musculoskeletal pain and to observe whether dysregulated miRNAs can distinguish between responders and nonresponders to a kinesiological intervention. The possible correlation between these miRNAs and inflammatory molecules, stress parameters and individual or behavioral characteristics will be evaluated. Finally, in silico analysis will be used to characterize miRNAs function. Ethics approval was obtained.

Automated summary

miRNAs play a role in musculoskeletal pain development, which has significant clinical, economic, and social impact. This study aims to evaluate the association between miRNAs in circulation and saliva and pain in runners, as well as to identify miRNAs that can distinguish between responders and nonresponders to a kinesiological intervention. Possible correlations between these miRNAs and inflammatory molecules, stress parameters, and individual/behavioral characteristics will be examined. In silico analysis will also be used to understand miRNAs function. Ethics approval has been obtained.