Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume -, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1007/s12265-023-10401-w
Keywords
Mesenchymal stem cells; Exosomes; Myocardial ischemia-reperfusion injury; Oxidative stress; Inflammation; Regulated cell death; ncRNAs
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Ischemic cardiomyopathy is treated mainly with thrombolytic drugs, percutaneous coronary intervention, and coronary artery bypass grafting. Myocardial ischemia-reperfusion injury (MIRI) is a complication of obstructive revascularization with limited therapeutic options. Mesenchymal stem cell-derived exosomes (MSC-EXOs) can alleviate MIRI and prevent limitations caused by direct MSC administration. Using MSC-EXOs instead of MSCs is a potentially beneficial cell-free treatment strategy for MIRI.
Ischemic cardiomyopathy is treated mainly with thrombolytic drugs, percutaneous coronary intervention, and coronary artery bypass grafting to recanalize blocked vessels. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable complication of obstructive revascularization. Compared with those of myocardial ischemic injury, few effective therapeutic options are available for MIRI treatment. The pathophysiological mechanisms of MIRI involve the inflammatory response, the immune response, oxidative stress, apoptosis, intracellular Ca2+ overload, and cardiomyocyte energy metabolism. These mechanisms exacerbate MIRI. Mesenchymal stem cell-derived exosomes (MSC-EXOs) can alleviate MIRI through these mechanisms and, to some extent, prevent the limitations caused by direct MSC administration. Therefore, using MSC-EXOs instead of MSCs to treat MIRI is a potentially beneficial cell-free treatment strategy. In this review, we describe the mechanism of action of MSC-EXO-derived noncoding RNAs in the treatment of MIRI and discuss the advantages and limitations of this strategy, as well as possible future research directions.
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