Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 103, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2023.105489
Keywords
Chlorella pyrenoidosa; Diabetes; Molecular mechanism; Short-chain fatty acids; Gut microbiota
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This study aimed to investigate the hypoglycemic effect of Chlorella pyrenoidosa functional formulations (CFF) on STZ-induced high-glucose and high-fat diet-fed mice. CFF significantly reduced weight loss, liver deformation, cecum injury, and jejunal inflammation in type 2 diabetic mice. In addition, CFF enriched gut probiotics, inhibited harmful microorganisms, and enhanced production of short-chain fatty acids.
This study was aimed at investigating the hypoglycemic effect of Chlorella pyrenoidosa functional formulations (CFF), composed of extracts of C. pyrenoudosa, Ganoderma lucidum, and Panax ginseng with chromium-enriched yeast, on streptozotocin (STZ)-induced high-glucose and high-fat diet-fed mice. In this study, CFF significantly reduced the symptoms of weight loss, liver deformation, cecum injury, and jejunal inflammation in type 2 diabetic mice. In addition to enriching gut probiotics, CFF inhibited harmful microorganisms that could affect glycolipid metabolism disorders (GLD) and enhanced production of short-chain fatty acids. In conclusion, CFF may be able to alleviate GLD symptoms. The study suggests that CFF regulates GLD and the possible mechanisms for this regulation. This provides a theoretical basis for developing nutritious and healthy foods.
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