Mitophagy in ototoxicity

Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways. The results of ototoxicity models indicate the importance of this process in the etiology of ototoxicity. A number of recent investigations of the control of cell fate by mitophagy have enhanced our understanding of the mechanisms by which mitophagy regulates ototoxicity and other hearing-related diseases, providing opportunities for targeting mitochondria to treat ototoxicity.

Automated summary

Mitochondrial dysfunction is associated with ototoxicity caused by external factors. The regulation of mitophagy, through key mitophagy regulatory proteins and signaling pathways, plays a crucial role in maintaining mitochondrial homeostasis and function. Recent investigations on the control of cell fate by mitophagy have improved our understanding of the mechanisms underlying ototoxicity and other hearing-related diseases, offering potential opportunities for targeted mitochondrial therapies in the treatment of ototoxicity.