Amputation and limb salvage following endovascular and open surgery for the treatment of peripheral artery illnesses: A meta-analysis

A meta-analysis investigation was executed to measure the outcome of endovascular surgery (ES) and open surgery (OS) for the management of peripheral artery diseases (PADs) on amputation and limb salvage (LS). A comprehensive literature inspection till February 2023 was applied and 3451 interrelated investigations were reviewed. The 31 chosen investigations enclosed 19 948 individuals with PADs were in the chosen investigations' starting point, 8861 of them were utilising ES, and 11 087 were utilising OS. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were utilised to compute the value of the effect of ES and OS for the management of PADs on amputation and LS by the dichotomous approaches and a fixed or random model. ES had significantly lower amputation (OR, 0.80; 95% CI, 0.68-0.93, P = 0.005) compared with those with OS in individuals with PADs. No significant difference was found between ES and OS in 30-day LS (OR, 0.95; 95% CI, 0.64-1.42, P = 0.81), 1-year LS (OR, 1.06; 95% CI, 0.81-1.39, P = 0.68), and 3-year LS (OR, 0.86; 95% CI, 0.61-1.19, P = 0.36) in individuals with PADs. ES had significantly lower amputation, 30-day LS, 1-year LS, and 3-year LS compared with those with OS in individuals with PADs. However, care must be exercised when dealing with its values because of the low sample size of some of the nominated investigations for the meta-analysis.

Automated summary

A meta-analysis was conducted to compare the outcomes of endovascular surgery (ES) and open surgery (OS) in managing peripheral artery diseases (PADs) with regards to amputation and limb salvage (LS). The analysis included 31 studies with a total of 19,948 individuals with PADs, of which 8,861 underwent ES and 11,087 underwent OS. The findings showed that ES significantly reduced the risk of amputation compared to OS in PADs patients. However, there was no significant difference between ES and OS in terms of limb salvage at 30 days, 1 year, and 3 years in PADs patients. These results highlight the potential benefits of ES in reducing amputation risk in PADs patients, although caution should be exercised due to the small sample size of some included studies.