Journal
VIRUSES-BASEL
Volume 15, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/v15040942
Keywords
antiviral; Borna disease virus; neuronal cells; gene expression; differentiation
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This study investigated the effects of BoDV-1 infection on neuronal differentiation and the transcriptome of differentiated neuronal cells. It was found that the infection caused transcriptomic changes in differentiation-related genes, some of which could be recovered by anti-BoDV-1 treatment. Furthermore, the study demonstrated that anti-BoDV-1 treatment could relieve the decrease in cell viability induced by differentiation processes in infected cells.
Borna disease virus (BoDV-1) is a highly neurotropic RNA virus that causes neurobehavioral disturbances such as abnormal social activities and memory impairment. Although impairments in the neural circuits caused by BoDV-1 infection induce these disturbances, the molecular basis remains unclear. Furthermore, it is unknown whether anti-BoDV-1 treatments can attenuate BoDV-1-mediated transcriptomic changes in neuronal cells. In this study, we investigated the effects of BoDV-1 infection on neuronal differentiation and the transcriptome of differentiated neuronal cells using persistently BoDV-1-infected cells. Although BoDV-1 infection did not have a detectable effect on intracellular neuronal differentiation processes, differentiated neuronal cells exhibited transcriptomic changes in differentiation-related genes. Some of these transcriptomic changes, such as the decrease in the expression of apoptosis-related genes, were recovered by anti-BoDV-1 treatment, while alterations in the expression of other genes remained after treatment. We further demonstrated that a decrease in cell viability induced by differentiation processes in BoDV-1-infected cells can be relieved with anti-BoDV-1 treatment. This study provides fundamental information regarding transcriptomic changes after BoDV-1 infection and the treatment in neuronal cells.
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