Journal
VIRUSES-BASEL
Volume 15, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/v15051205
Keywords
children; juvenile idiopathic arthritis; omicron; questionnaire; SARS-CoV-2; severity; systemic lupus erythematosus
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This study aimed to report the clinical features of concurrent COVID-19 and pediatric rheumatic disease (PRD) in Japan. The survey showed that 82% of hospitals had children with PRD and COVID-19, and the majority of them were asymptomatic or had mild symptoms. Therefore, COVID-19 is not a threat to children with PRD in Japan.
Coronavirus disease 2019 (COVID-19) in children can be compounded by concurrent diseases and immunosuppressants. For the first time, we aimed to report the clinical features of concurrent COVID-19 and pediatric rheumatic disease (PRD) in Japan. Pediatric Rheumatology Association of Japan members were surveyed between 1 April 2020 and 31 August 2022. Outcome measurements included the clinical features of concurrent PRD and COVID-19. Questionnaire responses were obtained from 38 hospitals. Thirty-one hospitals (82%) had children with PRD and COVID-19. The female-to-male ratio in these children (n = 156) was 7:3, with half aged 11-15 years. The highest proportion of children with PRD and COVID-19 was accounted for by juvenile idiopathic arthritis (52%), followed by systemic lupus erythematosus (24%), juvenile dermatomyositis (5%), scleroderma (4%), and Takayasu arteritis (3%). Of children with PRD, a significant majority (97%) were found to be asymptomatic (10%) or presented with mild symptoms (87%) of the COVID-19 infection. No severe cases or deaths were observed. Regarding the use of glucocorticoids, immunosuppressants, or biologics for PRD treatment before COVID-19, no significant difference was found between asymptomatic/mild and moderate COVID-19 in children with PRD. Therefore, COVID-19 is not a threat to children with PRD in Japan.
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