4.6 Article

French Phage Network Annual Conference-Seventh Meeting Report

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Antibiotics that affect translation can antagonize phage infectivity by interfering with the deployment of counter-defenses

Benoit J. Pons et al.

Summary: Our study shows that antibiotics targeting the protein translation machinery can alter the outcome of bacteria-phage interactions by interfering with the production of phage-encoded counter-defense proteins. Specifically, bacteria with CRISPR-Cas immune systems have elevated immunity against phage encoding anti-CRISPR genes when translation inhibitors are present.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Article Cell Biology

Genetic determinants of host tropism in Klebsiella phages

Beatriz Beamud et al.

Summary: Bacteriophages play key roles in bacterial ecology and evolution and are potential antimicrobials. However, the determinants of phage-host specificity remain elusive. In this study, 46 phages were isolated and tested against 138 clinical isolates of Klebsiella pneumoniae, revealing a narrow host range for most phages. Bacterial capsule diversity was found to be the main factor limiting phage host range, while phage-encoded depolymerases and their sequence types were associated with the ability to infect specific capsular types.

CELL REPORTS (2023)

Article Biochemistry & Molecular Biology

Microbial defenses against mobile genetic elements and viruses: Who defends whom from what?

Eduardo P. C. Rocha et al.

Summary: Prokaryotes possess mobile genetic elements that enable horizontal gene transfer between cells. These elements contain defense systems to filter, control, or inactivate other elements. The abundance of defense systems in these mobile genetic elements sheds new light on their role as tools of intragenomic conflict.

PLOS BIOLOGY (2022)

Article Microbiology

Phages and their satellites encode hotspots of antiviral systems

Francois Rousset et al.

Summary: Bacteria have various genetic systems to defend against viral infection, including those within prophages. Phage satellites pose additional pressures on phages by hijacking viral elements. This study found that E. coli P2-like phages and their P4-like satellites carry genetic hotspots with anti-phage systems. These hotspots participate in inter-viral competition and shape dynamics between the bacterial host, P2-like phages, and P4-like satellites. Importantly, the anti-phage activity of satellites can benefit the helper phage during competition, turning a parasitic relationship into a mutualistic one.

CELL HOST & MICROBE (2022)

Article Genetics & Heredity

Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis

Rodrigo Ibarra-Chavez et al.

Summary: Phage-inducible chromosomal islands (PICIs) are highly mobile genetic elements that disseminate virulence and toxin genes among bacterial populations. Recent research has shown that PICIs promote bacterial diversity and protect the bacterial population from phage attack.

PLOS GENETICS (2022)

Article Microbiology

Bacteriophages vehiculate a high amount of antibiotic resistance determinants of bacterial origin in the Orne River ecosystem

Charlene Sagrillo et al.

Summary: The study found that when packaging bacterial DNA, bacteriophages encapsulate antibiotic resistance genes and mobile genetic elements more than chromosomal fragments. Antibiotic resistance genes and mobile genetic elements in bacteria and bacteriophages are similarly influenced by seasonality, but their distribution between different physical compartments in rivers is more impacted when carried by bacteria.

ENVIRONMENTAL MICROBIOLOGY (2022)

Article Multidisciplinary Sciences

Prokaryotic innate immunity through pattern recognition of conserved viral proteins

Linyi Alex Gao et al.

Summary: It has been discovered that antiviral STAND homologs in bacteria and archaea can detect viral proteins and trigger immune responses to prevent infection. Cryo-electron microscopy reveals that these homologs are capable of recognizing multiple viruses.

SCIENCE (2022)

Article Microbiology

Phage-Plasmids Spread Antibiotic Resistance Genes through Infection and Lysogenic Conversion

Eugen Pfeifer et al.

Summary: Antibiotic resistance is rapidly spreading through horizontal transfer mediated by phage-plasmids, which carry a diverse range of clinically relevant antibiotic resistance genes and can transfer them across bacteria.
Article Immunology

Bacterial origins of human cell-autonomous innate immune mechanisms

Tanita Wein et al.

Summary: This paper describes the elements of antiviral immunity that are conserved from bacteria to humans and presents possible evolutionary scenarios to explain this conservation.

NATURE REVIEWS IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Prokaryotic viperins produce diverse antiviral molecules

Aude Bernheim et al.

Summary: Eukaryotic viperins originated from a clade of bacterial and archaeal proteins that protect against phage infection. These proteins produce modified ribonucleotides to combat viruses. Prokaryotic viperins can inhibit T7 phage infection by blocking viral polymerase-dependent transcription.

NATURE (2021)

Article Ecology

Pervasive prophage recombination occurs during evolution of spore-forming Bacilli

Anna Dragos et al.

Summary: Under a sporulation selection regime, recombination between SP beta and low copy number phi3Ts phage DNA in Bacillus subtilis leads to the formation of a new prophage and the release of virulent phage hybrids. These phages belong to a unique cluster of large phages inserted into sporulation-related genes, indicating diversification of SP beta-like phages in nature. This study sheds light on the eco-evolutionary relationships between bacteria and their phages by capturing the early stages of phage evolution.

ISME JOURNAL (2021)

Article Biochemistry & Molecular Biology

Bacteria have numerous distinctive groups of phage-plasmids with conserved phage and variable plasmid gene repertoires

Eugen Pfeifer et al.

Summary: Plasmids and temperate phages play crucial roles in bacterial evolution. Some elements, known as phage-plasmids, have been identified as both plasmids and phages. A study identified 780 phage-plasmids among a large number of phages and plasmids, grouped them into different categories, and suggested their ancient origins.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

Methane-derived carbon flows into host-virus networks at different trophic levels in soil

Sungeun Lee et al.

Summary: This study identified active interactions between individual host and virus populations in acidic and neutral pH soils fueled by methane, revealing that over one-third of enriched carbon isotopes in viruses contained homologs of genes from known methylotrophic bacteria. Viruses infecting nonmethanotrophic methylotrophs and heterotrophic predatory bacteria were also identified through shared homologous genes, showing that carbon is transferred to a diverse range of viruses within methane-fueled microbial networks.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Temporal compartmentalization of viral infection in bacterial cells

Audrey Labarde et al.

Summary: Infection of Bacillus subtilis by bacteriophage SPP1 leads to the hijacking of host replication proteins to assemble hybrid viral-bacterial replisomes, doubling the cell total DNA content within 15 minutes. The replisomes operate at several independent locations within a single viral DNA focus positioned asymmetrically in the cell. These findings demonstrate that bacteriophages restructure the host cytoplasm to confine the essential processes for their multiplication at different cellular locations.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Biochemistry & Molecular Biology

The Enemy of My Enemy: New Insights Regarding Bacteriophage-Mammalian Cell Interactions

Katie Bodner et al.

Summary: Bacteriophages play a crucial role in human health by altering the severity of bacterial infections, and recent studies have uncovered their ability to modulate the physiology of mammalian cells. Understanding the interactions between phages and mammalian cells has important implications for phage therapy.

TRENDS IN MICROBIOLOGY (2021)

Review Microbiology

Phage satellites and their emerging applications in biotechnology

Rodrigo Ibarra-Chavez et al.

Summary: The arms race between phages and their hosts is a hot spot for genome evolution, with phage satellites parasitizing phages for their own propagation and horizontal transfer. The study of these elements offers exciting possibilities for diverse biotech applications in microbiology and synthetic biology.

FEMS MICROBIOLOGY REVIEWS (2021)

Review Immunology

Contribution of the Immune Response to Phage Therapy

Oleg Krut et al.

JOURNAL OF IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Systematic discovery of antiphage defense systems in the microbial pangenome

Shany Doron et al.

SCIENCE (2018)

Article Cell Biology

The Phage Nucleus and Tubulin Spindle Are Conserved among Large Pseudomonas Phages

Vorrapon Chaikeeratisak et al.

CELL REPORTS (2017)

Article Biochemistry & Molecular Biology

Type II restriction endonucleases-a historical perspective and more

Alfred Pingoud et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Multidisciplinary Sciences

The new frontier of genome engineering with CRISPR-Cas9

Jennifer A. Doudna et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

CRISPR provides acquired resistance against viruses in prokaryotes

Rodolphe Barrangou et al.

SCIENCE (2007)

Review Microbiology

Bacteriophage therapy

WC Summers

ANNUAL REVIEW OF MICROBIOLOGY (2001)