4.6 Article

Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda

Journal

VIRUSES-BASEL
Volume 15, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/v15041005

Keywords

human papillomavirus; HIV; mucous membrane; cervical cancer; Rwanda

Categories

Ask authors/readers for more resources

HPV infections are prevalent in HIV-positive couples in Rwanda, but concordance within couples is low. Vaginal self-sampling can represent cervical HPV status.
Background: The prevalence of human papillomavirus (HPV) infections in other anatomical sites besides the uterine cervix is unknown in East Africa. Here, we assessed the prevalence and concordance of HPVs in different anatomical sites in HIV concordant couples in Rwanda. Methods: Fifty HIV-positive concordant male-female couples at the HIV clinic at the University Teaching Hospital of Kigali in Rwanda were interviewed, swabbed from the oral cavity (OC), oropharynx (OP), anal canal (AC), vagina (V), uterine cervix (UC) and penis. A pap smear test and a self-collected vaginal swab (Vself) were taken. Twelve high-risk (HR)-HPVs were analyzed. Results: HR-HPVs occurred in 10%/12% in OC, 10%/0% in OP and 2%/24% in AC (p = 0.002) in men and women, respectively. HR-HPVs occurred in 24% of UC, 32% of Vself, 30% of V and 24% of P samples. Only 22.2% of all HR-HPV infections were shared by both partners (kappa -0.34 +/- 0.11; p = 0.004). The type-specific HR-HPV concordance was significant between male to female OC-OC (kappa 0.56 +/- 0.17), V-VSelf (kappa 0.70 +/- 0.10), UC-V (kappa 0.54 +/- 0.13), UC-Vself (kappa 0.51 +/- 0.13) and UC-female AC (kappa 0.42 +/- 0.15). Conclusions: HPV infections are prevalent in HIV-positive couples in Rwanda but concordance within couples is low. Vaginal self-sampling for HPV is representative of cervical HPV status.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available