Efficacy of initiating urate-lowering therapy during an acute gout episode: a meta-analysis

Article Medicine, Research & Experimental

Early urate-lowering therapy in gouty arthritis with acute flares: a double-blind placebo controlled clinical trial

Deng-Ho Yang et al.

Summary: This study evaluated the effect of early urate-lowering therapy on acute flares of gouty arthritis. The results showed that early aggressive control of hyperuricemia using probenecid plus colchicine led to a rapid decrease in serum uric acid levels, but did not significantly alleviate arthritis pain.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2023)

Add to Collection

Article Rheumatology

The effect of initiation of urate-lowering treatment during a gout flare on the current episode: a meta-analysis of randomized controlled trials

Ertao Jia et al.

Summary: This study evaluated the clinical efficacy of urate-lowering treatment (ULT) in acute gout and found that initiation of ULT during an acute gout flare did not prolong the duration of the flare.

ADVANCES IN RHEUMATOLOGY (2022)

Add to Collection

Article Rheumatology

Early versus Late Allopurinol Initiation in Acute Gout Flare (ELAG): a randomized controlled trial

Panchalee Satpanich et al.

Summary: Early initiation of allopurinol during an acute gout flare did not result in significant changes in time to resolution, flare recurrence, and inflammatory markers.

CLINICAL RHEUMATOLOGY (2022)

Add to Collection

Review Rheumatology

The Mechanism of the NLRP3 Inflammasome Activation and Pathogenic Implication in the Pathogenesis of Gout

Seong-Kyu Kim

Summary: The NLRP3 inflammasome plays a crucial role in the pathogenesis of gout by triggering an inflammatory response and releasing pro-inflammatory cytokines. Activation of the NLRP3 inflammasome is a potential target for the treatment of acute gouty arthritis and prevention of gout flares.

JOURNAL OF RHEUMATIC DISEASES (2022)

Add to Collection

Article Rheumatology