Novel mutations in a second primary gastric cancer in a patient treated for primary colon cancer

Article Oncology

The protein-protein interaction network of intestinal gastric cancer patients reveals hub proteins with potential prognostic value

Everton Cruz Santos et al.

Summary: This study investigates the protein profile of tumor samples from patients with intestinal gastric cancer (IGC) and reveals important biological alterations associated with IGC development. Bioinformatics analysis shows that the pathogenesis of IGC is complex, involving interconnected biological processes. These findings are valuable for research on new therapeutic targets and novel therapies to improve the overall survival of IGC patients.

CANCER BIOMARKERS (2022)

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Article Genetics & Heredity

KMT2A: Umbrella Gene for Multiple Diseases

Silvia Castiglioni et al.

Summary: KMT2A is an essential member of the epigenetic machinery, involved in transcriptional activation and playing a crucial role in gene expression. Mutations in KMT2A are associated with pathological conditions, including various chromatinopathies and tumors. The gene is important for embryonic development, hematopoiesis, and neurodevelopment, and holds potential as a therapeutic target in related disorders.

GENES (2022)

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Article Medicine, Research & Experimental

Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer

Therese Seidlitz et al.

Summary: This study generated three murine organoid models to investigate the impact of different pathway alterations on gastric cancer. It identified a potential treatment approach for gastric cancer patients with RTK/MAPK pathway alterations, suggesting their susceptibility to HDAC inhibition.

EMBO MOLECULAR MEDICINE (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Multidisciplinary Sciences

The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer

Hiroki Izumi et al.

Summary: Lung cancer is a highly aggressive tumor type, and targeted therapies based on oncogenic drivers have greatly improved outcomes for patients with non-small-cell lung cancer (NSCLC). However, a significant percentage of lung adenocarcinoma cases lack known oncogenic drivers, and the identification of the CLIP1-LTK fusion as a potential target in NSCLC represents a novel finding with therapeutic implications.

NATURE (2021)

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Article Cell Biology