Multi-ligand functionalized blood-to-tumor sequential targeting strategies in the field of glioblastoma nanomedicine

Review Biotechnology & Applied Microbiology

Micro and nanotechnologies: The little formulations that could

Rebeca T. Stiepel et al.

Summary: Micro- and nanotechnology has revolutionized medical applications, including vaccines, drugs, and imaging. While there have been remarkable successes in this field, challenges such as production and financial issues still exist.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

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Article Chemistry, Multidisciplinary

Smart Nanomedicine to Enable Crossing Blood-Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma

Hairong Wang et al.

Summary: In this study, a BBB-crossing copolymer was successfully fabricated using a choline analogue MPC, leading to efficient delivery of ICB therapy in a glioma model and significantly prolonging animal survival.

ACS NANO (2022)

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Article Chemistry, Medicinal

Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma

Jiaqi Lu et al.

Summary: In this study, pH-sensitive multi-targeted liposomes were developed for the co-delivery of doxorubicin and lonidamine to brain tumors. These liposomes exhibited excellent pharmacokinetic properties, crossed the blood-brain barrier, and targeted tumor cells. Once inside the cells, the liposomes were positively charged and accumulated in the mitochondria, resulting in the synergistic release of the two drugs and enhanced anti-tumor efficacy. In vitro and in vivo experiments demonstrated that these liposomes significantly inhibited tumor cell proliferation, migration, and invasion, induced apoptosis and necrosis, and interfered with mitochondrial function. They also prolonged the survival of mice with glioma, reduced tumor size, and inhibited tumor infiltration and metastasis.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Engineering, Biomedical

Towards principled design of cancer nanomedicine to accelerate clinical translation

Mohammad Souri et al.

Summary: Nanotechnology has shown promising results in medical applications, particularly in oncology as drug delivery systems. However, the clinical translation of this technology is challenging. To optimize drug delivery systems for clinical translation, the physicochemical characteristics of nanoparticles can be specified. Researchers have focused on producing biocompatible materials, production technologies, or new formulations to improve efficiency and stability. The effects of design parameters can be studied using various methods. This review summarizes the advances and technologies in cancer nanomedicines for clinical translation and commercialization, as well as the existing challenges and opportunities in the field.

MATERIALS TODAY BIO (2022)

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Review Pharmacology & Pharmacy

Nanomedicine for brain cancer

Sabina Quader et al.

Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Neurosciences

The chick embryo chorioallantoic membrane as an experimental model to study in vivo angiogenesis in glioblastoma multiforme

Domenico Ribatti

Summary: The chick embryo CAM assay is a useful tool for studying angiogenesis and metastatic potential in GBM, as well as assessing the efficacy of anti-angiogenic drugs.

BRAIN RESEARCH BULLETIN (2022)

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Review Oncology

Effect of post-diagnosis exercise on depression symptoms, physical functioning and mortality in breast cancer survivors: A systematic review and meta-analysis of randomized control trials

Abdul Salam et al.

Summary: This meta-analysis evaluated the effects of post-diagnosis exercises on depression, physical functioning, and mortality in breast cancer survivors. The results showed that exercise intervention led to improvements in depression levels and significant reductions in breast cancer-specific and all-cause mortality rates. Future studies should focus on incorporating physical activity as part of daily routine to improve the quality of life for breast cancer survivors.

CANCER EPIDEMIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers

Masoud Farshbaf et al.

Summary: This study developed a targeted delivery system based on nanostructured lipid carriers, which can effectively overcome the blood-brain barrier and blood-brain tumor barrier, and deliver therapeutics to glioma cells with high selectivity. It represents a promising treatment for brain cancer.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Receptor-mediated cascade targeting strategies for the application to medical diagnoses and therapeutics of glioma

Man Liang et al.

Summary: This article introduces the challenges in the treatment of glioma and a new therapeutic strategy called receptor-mediated cascade targeting (RMCT). The RMCT strategy, by targeting ligands to both the blood-brain barrier and the blood-brain tumor barrier, aims to enhance drug delivery efficacy for accurate diagnosis and treatment of glioma.

JOURNAL OF NANOPARTICLE RESEARCH (2022)

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Article Pharmacology & Pharmacy

Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy

Xuemeng Li et al.

PHARMACOLOGICAL RESEARCH (2022)

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Review Pharmacology & Pharmacy

Integrin-alpha v beta 3 as a Therapeutic Target in Glioblastoma: Back to the Future?

William Echavidre et al.

Summary: Glioblastoma (GBM) is the most common primary malignant brain tumor with poor prognosis, and integrins play a key role in GBM invasion. Therapeutic targeting of αvβ3 has become a focus of research.

PHARMACEUTICS (2022)

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Review Biochemistry & Molecular Biology

The Vascular Microenvironment in Glioblastoma: A Comprehensive Review

Alejandra Mosteiro et al.

Summary: This review focuses on the vascular microenvironment of glioblastoma, discussing the components of the perivascular niche, vascular generation patterns and signaling pathways, endothelial-tumor interrelation, and the connection between vessel aberrancies and immune disarrangement. The revised concepts provide novel insights into the failure of conventional anti-angiogenic therapies.

BIOMEDICINES (2022)

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Review Biochemistry & Molecular Biology

Nanoparticles Loaded with Docetaxel and Resveratrol as an Advanced Tool for Cancer Therapy

Magdalena Jurczyk et al.

Summary: There is a growing interest in the use of chemosensitizers and cytostatics in combination to overcome cancer resistance to treatment. To overcome challenges such as poor bioavailability and chemical instability of drugs, attempts have been made to create nanoparticles for the delivery of docetaxel (Dtx) and resveratrol (Res). Recent reports suggest that nano-delivery systems for Dtx and Res exhibit better efficiency in cancer treatment than free drugs, and the simultaneous release of both drugs in cancer cells may help overcome limitations caused by multidrug resistance.

BIOMEDICINES (2022)

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Review Chemistry, Multidisciplinary

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

Catia Domingues et al.

Summary: Worldwide development and application of nanotechnology have led to significant scientific advancements. It is important to balance the high expectations and concerns associated with this field. Nanomedicine, a specific arm of nanotechnology, focuses on the diagnosis, treatment, and monitoring of various diseases. However, the concept of nanotoxicology has also emerged as a crucial aspect of nanomedicine. More research is needed to identify potential adverse effects and ensure the safety of nanomedicines.

ACS NANO (2022)

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Review Chemistry, Medicinal

Regulatory Science Approach in Pharmaceutical Development of Follow-on Versions of Non-Biological Complex Drug Products

Daniela M. Zagalo et al.

Summary: Scientific and technological breakthroughs in the field of Nanotechnology have played a significant role in the development and approval of Non-Biological Complex Drugs (NBCDs). However, the rapid expansion of NBCDs and their follow-on versions have posed various challenges in terms of science, technology, and regulation. The lack of official recognition and dedicated regulatory pathway for NBCDs, as well as the absence of clear and consistent guidance documents, have hindered the acceptance and potential of these drug products. The inconsistent regulatory approaches across different agencies and countries have also created uncertainty and may affect patient access to high-quality NBCD follow-on versions. Therefore, there is a need to establish a specific regulatory pathway or optimize existing pathways to address the complexity of NBCDs and their follow-on versions. This review aims to critically examine and provide an overview of the current regulatory landscape of NBCDs and follow-on versions, with the goal of filling regulatory and scientific gaps in establishing therapeutic equivalence.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Brain Cancer Chemotherapy through a Delivery System across the Blood-Brain Barrier into the Brain Based on Receptor-Mediated Transcytosis Using Monoclonal Antibody Conjugates

Toshihiko Tashima

Summary: Advancements in pharmacotherapy have greatly benefited humanity, but there are still unmet medical needs in the treatment of CNS diseases and cancers. The blood-brain barrier poses a challenge in delivering drugs to the brain, while the complex mechanisms of cancer and its off-target effects make the development of anti-cancer drugs difficult. Antibody drugs and antibody-drug conjugates show promise in treating CNS diseases and brain cancer.

BIOMEDICINES (2022)

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Review Pharmacology & Pharmacy

Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment

Nikhil Pandey et al.

Summary: This review focuses on drug delivery strategies and nanotherapeutic technologies targeting brain-invading cancer cells and highlights the importance of treatments for invasive cells.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Biochemistry & Molecular Biology

Berberine and folic acid co-modified pH-sensitive cascade-targeted PTX-liposomes coated with Tween 80 for treating glioma

Chunyan Yang et al.

Summary: In this study, an intelligent liposome drug delivery system was constructed by co-modifying liposomes with folate (FA) derivatives and mitochondria-targeting berberine (BBR) derivatives. The system achieved enhanced therapeutic efficacy of chemotherapy for glioma through targeted delivery to glioma cells and mitochondria, and improved blood-brain barrier penetration by coating with Tween 80.

BIOORGANIC & MEDICINAL CHEMISTRY (2022)

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Review Medicine, General & Internal

Surgical Treatment of Glioblastoma: State-of-the-Art and Future Trends

Arthur H. A. Sales et al.

Summary: In this study, a comprehensive literature review was conducted to explore the current state and future trends of surgical treatment for glioblastoma (GBM), with a focus on recent research topics.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Beyond Formulation: Contributions of Nanotechnology for Translation of Anticancer Natural Products into New Drugs

Rodrigo dos A. Miguel et al.

Summary: Nature is a rich source of medicinal compounds like doxorubicin (DOX) and paclitaxel (PTX). Nanoformulations of these drugs are cost-effective and offer improved pharmacokinetic properties and targeted delivery, resulting in reduced side effects. They can also overcome drug resistance and allow for multi-drug encapsulation for combined chemotherapy.

PHARMACEUTICS (2022)

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Review Biochemistry & Molecular Biology

More than Toxins-Current Prospects in Designing the Next Generation of Antibody Drug Conjugates

Jonathan Schwach et al.

Summary: ADCs have become a cornerstone in targeted cancer therapies, with rapid development of novel conjugation techniques and alternative payloads. Multi-specific antibody formats show great potential for the next generation of therapeutic antibody conjugates.

FRONTIERS IN BIOSCIENCE-LANDMARK (2022)

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Review Biochemistry & Molecular Biology

Antibody drug conjugate: the biological missile for targeted cancer therapy

Zhiwen Fu et al.

Summary: Antibody-drug conjugates (ADCs) combine the highly specific targeting ability of monoclonal antibodies with the potent killing effect of cytotoxic drugs to accurately and efficiently eliminate cancer cells. Since the approval of the first ADC in 2000, 14 ADCs have been marketed worldwide, with over 100 ADC candidates currently in clinical trials. These novel cancer therapeutics, known as biological missiles, are leading the way in targeted cancer therapy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Letter Cell & Tissue Engineering

Letter: Glioblastoma Cell of Origin

Ahmed Habib et al.

STEM CELL REVIEWS AND REPORTS (2022)

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Article Chemistry, Multidisciplinary

Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation

Wenxing Gu et al.

Summary: The article reviews the current status and prospects of targeted nanomedicines for cancer therapy, emphasizing their huge potential in treating various types of tumors and highlighting the importance of interdisciplinary collaborative research and development in becoming a key platform for precision cancer therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Polymeric nanoparticle vaccines to combat emerging and pandemic threats

David Wibowo et al.

Summary: Subunit vaccines have advantages in safety and scale-up manufacture compared to live attenuated vaccines, but often sacrifice efficacy. Polymeric nanoparticles have been developed to enhance vaccine potency by incorporating multiple immunological cues to mimic pathogens. Studies show that modulation of the physicochemical properties of nanoparticles can improve vaccine delivery and immune responses.

BIOMATERIALS (2021)

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Article Oncology

WORLD CANCER RESEARCH DAY: A Call to Action for a Coordinated International Research Effort to Prevent, Diagnose, and Treat Cancer

Marta Puyol et al.

Summary: Cancer is a major public health issue that is projected to double by 2040. The World Cancer Research Day aims to raise awareness and commitment for cancer research, highlighting the importance of collaborative efforts in addressing current challenges and accelerating impactful research for a better future.

CLINICAL CANCER RESEARCH (2021)

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Article Pharmacology & Pharmacy

Dual functional nanoparticles efficiently across the blood-brain barrier to combat glioblastoma via simultaneously inhibit the PI3K pathway and NKG2A axis

Zheng Jin et al.

Summary: This study developed a novel dual functional dendrimer drug delivery system for efficient inhibition of glioblastoma by crossing the blood-brain barrier and overcoming the immunosuppressive microenvironment within the tumor tissues. The system was able to simultaneously inhibit tumor-promoting signaling pathways and activate anti-tumor immunity, providing a promising strategy for combating glioblastoma.

JOURNAL OF DRUG TARGETING (2021)

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Review Pharmacology & Pharmacy

A quantitative view on multivalent nanomedicine targeting

Laura Woythe et al.

Summary: This review discusses the challenges and advancements in designing targeted nanoparticles for selective drug delivery in nanomedicine. The combination of new theoretical models and experimental methods provides a quantitative view of targeting, enabling the rational design and clinical translation of targeted nanomedicines.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Targeted delivery of small noncoding RNA for glioblastoma

Ji Young Yoo et al.

Summary: Aberrant gene and miRNA expression can drive cancer development, and the modulation of these expressions provides a therapeutic opportunity. Recent advances in RNA nanotechnology offer potential for miRNA therapy, but the lack of a delivery platform remains a challenge.

CANCER LETTERS (2021)

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Article Chemistry, Applied

pH-controlled nucleolin targeted release of dual drug from chitosan-gold based aptamer functionalized nano drug delivery system for improved glioblastoma treatment

Anbazhagan Sathiyaseelan et al.

Summary: A pH-responsive nano-drug delivery system was developed for enhanced glioblastoma treatment, showing improved cell death through dual drug release and confirmed drug internalization in cell organelles.

CARBOHYDRATE POLYMERS (2021)

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Review Biochemistry & Molecular Biology

An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

Juliana T. W. Tong et al.

Summary: The emergence of a large number of antibody-drug conjugates (ADCs) for cancer therapy has attracted significant attention globally, with 11 ADCs granted FDA approval as of September 2021, 8 of which have been approved since 2017. Despite challenges, optimism for this therapeutic approach remains high, as evidenced by a landmark year for deals and partnerships in the ADC arena in 2020.

MOLECULES (2021)

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Review Chemistry, Multidisciplinary

Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer

Muhammad Muzamil Khan et al.

Summary: Cell penetrating peptides (CPP) have the ability to efficiently internalize across biological membranes, making them effective for delivering chemotherapeutic agents when combined with tumor targeting peptides.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Biochemistry & Molecular Biology

Central nervous system delivery of molecules across the blood-brain barrier

Fabien Gosselet et al.

Summary: Therapies for neurological conditions face challenges due to the blood-brain barrier, but recent advances have provided new methods to overcome this obstacle. Combining approaches such as nanoparticles and magnetic resonance imaging-guided focused ultrasound shows promise for safely delivering therapeutic molecules into the brain.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Review Chemistry, Multidisciplinary

Development of Polymeric Nanoparticles for Blood-Brain Barrier Transfer-Strategies and Challenges

Weisen Zhang et al.

Summary: Polymeric nanoparticles have shown great potential in overcoming the blood-brain barrier for effective drug delivery, with their unique properties offering high tunability and ease of synthesis. Careful analysis of their performance in transporting drugs across the blood-brain barrier is essential for successful drug delivery to the central nervous system.

ADVANCED SCIENCE (2021)

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Article Pharmacology & Pharmacy

Polymer Pro-Drug Nanoparticles for Sustained Release of Cytotoxic Drugs Evaluated in Patient-Derived Glioblastoma Cell Lines and In Situ Gelling Formulations

Catherine E. Vasey et al.

Summary: Glioblastoma is the most common and aggressive brain tumor in adults, with limited survival despite multimodal treatments. PEGylated poly(lactide)-poly(carbonate)-doxorubicin nanoparticles showed tumor cell-killing effects, and the release of DOX from polymer-DOX conjugate nanoparticles in thermosensitive matrices was effective over clinically relevant time scales. Future in vivo assessments are needed to evaluate the potential of these nanoparticles in penetrating brain parenchyma.

PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Folate Receptors' Expression in Gliomas May Possess Potential Nanoparticle-Based Drug Delivery Opportunities

Eva McCord et al.

Summary: Brain cancer affected around 23,890 adults and 3540 children in 2020, with current FDA-approved chemotherapeutic agents proving to be ineffective due to interference from the tumor microenvironment and their own toxicities, as well as the restrictive permeability of the blood brain barrier. Targeted nanoparticulate drug delivery systems offer a promising opportunity to overcome this barrier and selectively target tumor cells, with folate receptors identified as useful targets for drug delivery to the brain.

ACS OMEGA (2021)

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Review Biochemistry & Molecular Biology

Challenge to overcome current limitations of cell-penetrating peptides

Gyu Chan Kim et al.

Summary: Cell-penetrating peptides (CPPs) serve as efficient vehicles for delivering pharmaceutical drugs across biological membranes. Research has focused on understanding the mechanism of penetration and exploring various biomedical applications. Strategies are being developed to overcome current limitations in stability, selectivity, and efficacy of CPPs.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2021)

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Review Biochemistry & Molecular Biology

Current FDA-Approved Therapies for High-Grade Malignant Gliomas

Jacob P. Fisher et al.

Summary: The standard of care for high-grade gliomas includes surgical resection, radiation therapy, and temozolomide, which have improved patient survival rates. Besides temozolomide, there are several other FDA-approved treatments for HGG, with tumor treatment fields being the only one shown to significantly improve survival rates.

BIOMEDICINES (2021)

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Letter Clinical Neurology

Area postrema syndrome in a patient with brainstem glioblastoma

K. S. Natsis et al.

ACTA NEUROLOGICA BELGICA (2021)

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Article Pharmacology & Pharmacy

Effect of polymer source on in vitro drug release from PLGA microspheres

Bo Wan et al.

Summary: The study aimed to investigate the impact of minor differences in PLGA polymers from different sources on their physicochemical properties and in vitro release characteristics. The results suggest that source-related variations may significantly affect the Q3 sameness and therapeutic performance of long-acting PLGA microspheres.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Physical

Obstacles and opportunities in a forward vision for cancer nanomedicine

Irene de Lazaro et al.

Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.

NATURE MATERIALS (2021)

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Article Multidisciplinary Sciences

Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging

Hamed Akbari et al.

Summary: The study utilized dynamic MRI and chemical exchange saturation transfer imaging to build a machine learning model for estimating tumor acidity in GBM patients. The results suggest that PCA analysis of DSC imaging data can predict MTRasym values effectively, especially in peritumoral regions.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Tumor-Associated Microglia and Macrophages in the Glioblastoma Microenvironment and Their Implications for Therapy

Rikke Sick Andersen et al.

Summary: Glioblastoma, the most common and malignant primary brain tumor, has a poor prognosis with limited treatment options. Targeting tumor-associated microglia and macrophages (TAMs) in addition to cancer cells may be a promising therapeutic strategy. Understanding the interactions between TAMs and cancer cells is crucial for developing effective treatment approaches.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Advanced Immunotherapy Approaches for Glioblastoma

Yifan Ma et al.

Summary: Glioblastoma multiforme (GBM) is the most aggressive primary central nervous system tumor, and immunotherapy has emerged as a promising approach for treating GBM, especially in combination with other classical cancer therapies. Additional systematic and in-depth investigations are required to further improve the efficacy of GBM immunotherapy for future clinical applications.

ADVANCED THERAPEUTICS (2021)

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Article Pharmacology & Pharmacy

Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential

Lin Di et al.

Summary: The article summarizes the use of natural and synthetic LDL-based carriers for drug delivery and imaging, discussing various targeting mechanisms.

DRUG DELIVERY (2021)

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Review Oncology

Emerging drug profile: CPX-351 (vyxeos) in AML

Mansour Alfayez et al.

LEUKEMIA & LYMPHOMA (2020)

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Review Pharmacology & Pharmacy

The blood-brain barrier: Physiology and strategies for drug delivery

Rucha Pandit et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Dexamethasone Loaded Liposomes by Thin-Film Hydration and Microfluidic Procedures: Formulation Challenges

M. D. Al-Amin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Editorial Material Chemistry, Medicinal

Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

Vanna Sanna et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Article Neurosciences

Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

Bhavesh K. Ahir et al.

MOLECULAR NEUROBIOLOGY (2020)

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Review Pharmacology & Pharmacy

Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies

Frederik Soetaert et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Biochemistry & Molecular Biology

iRGD and TGN co-modified PAMAM for multi-targeted delivery of ATO to gliomas

Xiaowei Shi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Neurosciences

Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

Saba Naqvi et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Review Oncology

Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies

Akilandeswari A. Balachandran et al.

CANCERS (2020)

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Article Oncology

Dual-Target Peptide-Modified Erythrocyte Membrane-Enveloped PLGA Nanoparticles for the Treatment of Glioma

Yuexin Cui et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Caveolae-mediated transport at the injured blood-brain barrier as an underexplored pathway for central nervous system drug delivery

Alexander G. Sorets et al.

CURRENT OPINION IN CHEMICAL ENGINEERING (2020)

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Article Multidisciplinary Sciences

On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias

Xiaohe Tian et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastoma

Alexander P. Landry et al.

SCIENTIFIC REPORTS (2020)

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Review Oncology

The blood-brain barrier and blood-tumour barrier in brain tumours and metastases

Costas D. Arvanitis et al.

NATURE REVIEWS CANCER (2020)

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Article Pharmacology & Pharmacy

Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation

Xiaoting Ren et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Review Pharmacology & Pharmacy

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology

Rui Pedro Moura et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Clinical Neurology

Association between Tumor Acidity and Hypervascularity in Human Gliomas Using pH-Weighted Amine Chemical Exchange Saturation Transfer Echo-Planar Imaging and Dynamic Susceptibility Contrast Perfusion MRI at 3T

Y. -L. Wang et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The L-Type Amino Acid Transporter LAT1An Emerging Target in Cancer

Pascal Hafliger et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Chemistry, Multidisciplinary

Survey of Clinical Translation of Cancer Nanomedicines-Lessons Learned from Successes and Failures

Hongliang He et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma

Sushant Lakkadwala et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Oncology

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act. In. Sarc): a multicentre, phase 2-3, randomised, controlled trial

Sylvie Bonvalot et al.

LANCET ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Cell-Penetrating Peptide and Transferrin Co-Modified Liposomes for Targeted Therapy of Glioma

Xi Wang et al.

MOLECULES (2019)

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Article Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016

Quinn T. Ostrom et al.

NEURO-ONCOLOGY (2019)

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Article Nanoscience & Nanotechnology

Dual-Modified Novel Biomimetic Nanocarriers Improve Targeting and Therapeutic Efficacy in Glioma

Shiyao Fu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Medicine, General & Internal

Brain metastases

Achal Singh Achrol et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Review Oncology

Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

Jann N. Sarkaria et al.

NEURO-ONCOLOGY (2018)

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Review Engineering, Biomedical

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Claudia Martins et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Oncology

Efficacy and safety findings from DREAM: a phase III study of DHP107 (oral paclitaxel) versus i.v. paclitaxel in patients with advanced gastric cancer after failure of first-line chemotherapy

Y-K Kang et al.

ANNALS OF ONCOLOGY (2018)

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Article Chemistry, Multidisciplinary

Highly efficacious and specific anti-glioma chemotherapy by tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides

Yaqin Zhu et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Chemistry, Multidisciplinary

Dual-targeted nanomedicines for enhanced tumor treatment

Yaqin Zhu et al.

NANO TODAY (2018)

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Review Clinical Neurology

Multidimensional communication in the microenvirons of glioblastoma

Marike L. Broekman et al.

NATURE REVIEWS NEUROLOGY (2018)

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Review Clinical Neurology

Glioblastoma niches: from the concept to the phenotypical reality

Davide Schiffer et al.

NEUROLOGICAL SCIENCES (2018)

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Article Chemistry, Multidisciplinary

Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy

Shengfeng Wang et al.

RSC ADVANCES (2018)

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Article Oncology

Spatiotemporal heterogeneity of tumor vasculature during tumor growth and antiangiogenic treatment: MRI assessment using permeability and blood volume parameters

Cherry Kim et al.

CANCER MEDICINE (2018)

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Article Chemistry, Medicinal

Dual Functionalized 5-Fluorouracil Liposomes as Highly Efficient Nanomedicine for Glioblastoma Treatment as Assessed in an In Vitro Brain Tumor Model

Sushant Lakkadwala et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Engineering, Biomedical

Transferrin/aptamer conjugated mesoporous ruthenium nanosystem for redox-controlled and targeted chemo-photodynamic therapy of glioma

Xufeng Zhu et al.

ACTA BIOMATERIALIA (2018)

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Article Oncology

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody-liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study

Pamela Munster et al.

BRITISH JOURNAL OF CANCER (2018)

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Review Radiology, Nuclear Medicine & Medical Imaging

Brain tumour post-treatment imaging and treatment-related complications

Alexander T. Kessler et al.

INSIGHTS INTO IMAGING (2018)

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Article Biochemistry & Molecular Biology

The Invasive Region of Glioblastoma Defined by 5ALA Guided Surgery Has an Altered Cancer Stem Cell Marker Profile Compared to Central Tumour

Stuart J. Smith et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma A Randomized Clinical Trial

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

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Drug-induced amino acid deprivation as strategy for cancer therapy

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

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NATURE COMMUNICATIONS (2017)

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ONCOTARGET (2017)

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NATURE REVIEWS CANCER (2017)

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Evaluation of the use of therapeutic peptides for cancer treatment

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JOURNAL OF BIOMEDICAL SCIENCE (2017)

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Critical review of the addition of tumor treating fields (TTFields) to the existing standard of care for newly diagnosed glioblastoma patients

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2017)

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Peptide-22 and Cyclic RGD Functionalized Liposomes for Glioma Targeting Drug Delivery Overcoming BBB and BBTB

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FUTURE ONCOLOGY (2016)

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An integrated assessment of morphology, size, and complement activation of the PEGylated liposomal doxorubicin products Doxil®, Caelyx®, DOXOrubicin, and SinaDoxosome

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Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

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MOLECULAR PHARMACEUTICS (2016)

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NATURE REVIEWS MATERIALS (2016)

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma A Randomized Clinical Trial

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

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ACTA BIOMATERIALIA (2014)

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MOLECULAR PHARMACEUTICS (2014)

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NEURO-ONCOLOGY (2008)

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ANNALS OF ONCOLOGY (2007)

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CURRENT MOLECULAR MEDICINE (2006)

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NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer

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ANNALS OF ONCOLOGY (2004)

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HER2 expression in breast cancer primary tumours and corresponding metastases.: Original data and literature review

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BRITISH JOURNAL OF CANCER (2003)

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Multi-ligand functionalized blood-to-tumor sequential targeting strategies in the field of glioblastoma nanomedicine

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