Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 73, Issue 3, Pages 340-346Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glw214
Keywords
Oxidative stress; Coenzyme Q(10); Mediterranean diet; Age-related diseases; Advanced glycation end products
Categories
Funding
- Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979, AGL2009-12270]
- Ministerio de Ciencia y Competitividad [AGL2012-39615, FIS PI10/01041, FIS PI13/00023]
- Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425, PI0193/09, PI-0252/09, PI-0058/10]
- Proyecto de Excelencia, Consejeria de Economia, Innovacion, Ciencia y Empleo [CVI-7450]
- Merck Serono
- Fundacion (Clinical Research in Cardiometabolic)
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Advanced glycation end products (AGEs) and oxidative stress are elevated with aging and dysmetabolic conditions. Because a Mediterranean (Med) diet reduces oxidative stress, serum AGEs levels, and gene expression related to AGEs metabolism in healthy elderly people, we studied whether supplementation with coenzyme Q(10) (CoQ) was of further benefit. Twenty participants aged >= 65 (10 men and 10 women) were randomly assigned to each of three isocaloric diets for successive periods of 4 weeks in a crossover design: Med diet, Med + CoQ, and a Western high-saturated-fat diet (SFA diet). After a 12-hour fast, volunteers consumed a breakfast with a fat composition similar to the previous diet period. Analyses included dietary AGEs consumed, serum AGEs and AGE receptor-1 (AGER1), receptor for AGEs (RAGE), glyoxalase I (GloxI), and estrogen receptor alpha (ER alpha) mRNA levels. Med diet modulated redox-state parameters, reducing AGEs levels and increasing AGER1 and GloxI mRNA levels compared with the SFA diet. This benefit was accentuated by adding CoQ, in particular, in the postprandial state. Because elevated oxidative stress/inflammation and AGEs are associated with clinical disease in aging, the enhanced protection of a Med diet supplemented with CoQ should be assessed in a larger clinical trial in which clinical conditions in aging are measured.
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