Journal
VIROLOGY JOURNAL
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12985-023-01996-2
Keywords
COVID-19; SARS-CoV-2; Organoid; Stem cell; Regenerative medicine
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Since December 2019, various strategies have been used to study the biology and pathogenesis of SARS-CoV-2 and discover effective treatments. One approach is using mini-organ technology to mimic COVID-19 and improve our understanding of the virus. Regenerative medicine research has shown the importance of organoid modeling in controlling COVID-19 through drug and therapeutic approach optimization.
Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.
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