4.4 Article

A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation

Related references

Note: Only part of the references are listed.
Review Medicine, Research & Experimental

Antiviral activities of flavonoids

Syed Lal Badshah et al.

Summary: Flavonoids, a group of natural phytochemicals, exhibit antiviral activity against various diseases caused by DNA and RNA viruses at different stages of viral infection. Some flavonoids have shown more potent antiviral activity than conventional drugs used for treating viral infections, with some compounds even protecting against lethal doses of virus in in vivo studies.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Biochemistry & Molecular Biology

Exploiting Dengue Virus Protease as a Therapeutic Target; Current Status, Challenges and Future Avenues

Mamona Mushtaq et al.

Summary: Dengue fever, caused by the dengue virus, infects approximately 400 million individuals annually, with factors contributing to its geographic expansion including urbanization, population density, and climate change. Despite progress, there is currently no effective antiviral therapy available, with research focusing on the NS2B-NS3 protease complex for potential treatments.

CURRENT MEDICINAL CHEMISTRY (2021)

Article Immunology

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2

Elisa Fanunza et al.

Summary: The viral protein NS2A suppresses the IFN signaling and promotes degradation of STAT1 and STAT2 to evade the innate immune system, helping Zika Virus escape host immune responses. Antagonism against IFN plays a crucial role in flavivirus virulence, and understanding how Zika Virus evades IFN response can pave the way for new strategies to attenuate the pathogenesis.

VIRULENCE (2021)

Review Microbiology

The continued threat of emerging flaviviruses

Theodore C. Pierson et al.

NATURE MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

Structural basis for STAT2 suppression by flavivirus NS5

Boxiao Wang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations

Jonathan B. Baell et al.

ACS CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation, and binding free energy calculation

Shanmugam Anusuya et al.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2017)

Article Multidisciplinary Sciences

Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity

Aphinya Suroengrit et al.

SCIENTIFIC REPORTS (2017)

Article Pharmacology & Pharmacy

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

Minhua Peng et al.

ANTIVIRAL RESEARCH (2017)

Article Infectious Diseases

Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

Claudia Fortuna et al.

BMC INFECTIOUS DISEASES (2017)

Article Microbiology

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Alesha Grant et al.

CELL HOST & MICROBE (2016)

Review Biochemistry & Molecular Biology

Dengue Virus Control of Type I IFN Responses: A History of Manipulation and Control

Jorge Andres Castillo Ramirez et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2015)

Review Immunology

New insights into the immunopathology and control of dengue virus infection

Gavin Screaton et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Immunology

Toll-like receptor signaling pathways

Takumi Kawasaki et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Immunology

Regulation of type I interferon responses

Lionel B. Ivashkiv et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

The global distribution and burden of dengue

Samir Bhatt et al.

NATURE (2013)

Review Pharmacology & Pharmacy

Structural biology of dengue virus enzymes: Towards rational design of therapeutics

Christian G. Noble et al.

ANTIVIRAL RESEARCH (2012)

Review Immunology

The JAK-STAT Pathway at Twenty

George R. Stark et al.

IMMUNITY (2012)

Review Virology

Innate Immunity Evasion by Dengue Virus

Juliet Morrison et al.

VIRUSES-BASEL (2012)

Article Microbiology

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

Sebastian Aguirre et al.

PLOS PATHOGENS (2012)

Article Multidisciplinary Sciences

MysiRNA-Designer: A Workflow for Efficient siRNA Design

Mohamed Mysara et al.

PLOS ONE (2011)

Article Microbiology

Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog

Yen-Liang Chen et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

Review Immunology

Recognition of viruses by cytoplasmic sensors

Courtney Wilkins et al.

CURRENT OPINION IN IMMUNOLOGY (2010)

Article Virology

Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel

Pornwaratt Niyomrattanakit et al.

JOURNAL OF VIROLOGY (2010)

Article Biochemistry & Molecular Biology

Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8

Tao Lan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Virology

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

Joseph Ashour et al.

JOURNAL OF VIROLOGY (2009)

Article Virology

Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore

Mark J. Schreiber et al.

JOURNAL OF VIROLOGY (2009)

Article Biochemistry & Molecular Biology

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation

Rachael Kenworthy et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

An adenosine nucleoside inhibitor of dengue virus

Zheng Yin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Pharmacology & Pharmacy

The flavivirus polymerase as a target for drug discovery

Helene Malet et al.

ANTIVIRAL RESEARCH (2008)

Article Chemistry, Multidisciplinary

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors

Kristin E. D. Coan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Review Pharmacology & Pharmacy

Pengue virus RNA polymerase NS5: A potential therapeutio target?

Stqphqn M. Rawlinson et al.

CURRENT DRUG TARGETS (2006)

Article Virology

Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses

JL Muñoz-Jordán et al.

JOURNAL OF VIROLOGY (2005)

Article Biotechnology & Applied Microbiology

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

AD Judge et al.

NATURE BIOTECHNOLOGY (2005)

Article Multidisciplinary Sciences

Inhibition of interferon signaling by dengue virus

JL Muñoz-Jordán et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)