4.5 Article

Effectiveness of COVID-19 vaccines at preventing emergency department or urgent care encounters and hospitalizations among immunocompromised adults: An observational study of real-world data across 10 US states from August-December 2021

Related references

Note: Only part of the references are listed.
Review Immunology

COVID-19 vaccine effectiveness among immunocompromised populations: a targeted literature review of real-world studies

Manuela Di Fusco et al.

Summary: A targeted literature review summarized 10 studies conducted between December 2020 and September 2021, revealing lower effectiveness of COVID-19 vaccines among immunocompromised populations compared to the general populations. It emphasizes the need for additional protective measures for immunocompromised individuals to prevent infection and associated illness.

EXPERT REVIEW OF VACCINES (2022)

Article Immunology

Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines for Preventing Coronavirus Disease 2019 Hospitalizations in the United States

Mark W. Tenforde et al.

Summary: From March to May 2021, full vaccination using authorized mRNA products was associated with 87.1% protection against COVID-19 hospitalization among US adults, with lower effectiveness in adults with immunosuppression compared to those without. Vaccination was beneficial for patients with immunosuppression, but the effectiveness was lower in this population.

CLINICAL INFECTIOUS DISEASES (2022)

Article Immunology

mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients

Jennie H. Kwon et al.

Summary: The effectiveness of COVID-19 mRNA vaccines in preventing COVID-19 hospitalization is lower for solid organ transplant (SOT) recipients compared to immunocompetent individuals and those with other immunocompromising conditions. Among SOT recipients, receiving 3 doses of an mRNA vaccine provides significantly greater protection than receiving 2 doses.

JOURNAL OF INFECTIOUS DISEASES (2022)

Article Immunology

Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)

Lindsay Kim et al.

Summary: This study identified factors associated with severe outcomes among adults hospitalized with COVID-19, including age, sex, comorbidities like obesity, immunosuppression, and diabetes. Older age, male gender, and certain underlying conditions were independently linked to increased risk of ICU admission and in-hospital mortality.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Effectiveness of Influenza Vaccine for Preventing Laboratory-Confirmed Influenza Hospitalizations in Immunocompromised Adults

Kailey Hughes et al.

Summary: This study evaluated the vaccine effectiveness against influenza hospitalization among immunocompromised adults during the 2017-2018 influenza season. The results showed that while immunocompromised adults had a higher vaccination rate, their protection against influenza was lower, with a vaccine effectiveness of 33% in the overall adult population. Further research is needed to assess vaccine effectiveness among different immunocompromising conditions and explore ways to improve effectiveness for immunocompromised individuals.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Administration of COVID-19 vaccines in immunocompromised patients

Manica Negahdaripour et al.

Summary: This review focuses on the challenges and considerations of COVID-19 vaccination in specific populations, such as patients with autoimmune diseases and those receiving immunosuppressive treatments. While confirmed data is lacking, reaching a consensus on vaccination for these populations is crucial, along with the need for further research and clinical trials to address these issues.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Medicine, General & Internal

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 A Prospective Cohort Study

Parakkal Deepak et al.

Summary: Patients with CID show immune response to mRNA-based SARS-CoV-2 vaccines, but some may have lower antibody levels, especially those receiving glucocorticoids and B-cell depletion therapy. Further studies are needed to confirm these preliminary findings.

ANNALS OF INTERNAL MEDICINE (2021)

Editorial Material Medicine, General & Internal

Covid-19 Vaccine Effectiveness and the Test-Negative Design

Natalie E. Dean et al.

Summary: Observational studies are becoming crucial for assessing vaccine effectiveness, especially when large randomized controlled trials are not feasible. These studies can monitor vaccine efficacy waning and assess the effectiveness against new coronavirus variants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

M. G. Thompson et al.

Summary: A study with a test-negative design analyzed 41,552 admissions to 187 hospitals and 21,522 visits to 221 EDs or urgent care clinics. The mRNA-based vaccines (>= 14 days after the second dose) were highly effective against SARS-CoV-2 infection leading to hospitalization (89%), ICU admission (90%), or an urgent care visit (91%).

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Public, Environmental & Occupational Health

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019-COVID-NET, 14 States, March 1-30, 2020

Shikha Garg et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

Article Public, Environmental & Occupational Health

Risk for In-Hospital Complications Associated with COVID-19 and Influenza - Veterans Health Administration, United States, October 1, 2018-May 31, 2020

Jordan Cates et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Review Public, Environmental & Occupational Health

Test-Negative Designs Differences and Commonalities with Other Case-Control Studies with Other Patient Controls

Jan P. Vandenbroucke et al.

EPIDEMIOLOGY (2019)

Article Public, Environmental & Occupational Health

Theoretical Basis of the Test-Negative Study Design for Assessment of Influenza Vaccine Effectiveness

Sheena G. Sullivan et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2016)

Letter Medicine, General & Internal

Prevalence of Immunosuppression Among US Adults, 2013

Rafael Harpaz et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Respiratory System

Validation of a Method to Identify Immunocompromised Patients with Severe Sepsis in Administrative Databases

Jared A. Greenberg et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2016)

Article Immunology

The test-negative design for estimating influenza vaccine effectiveness

Michael L. Jackson et al.

VACCINE (2013)