Liver-stage Plasmodium infection tunes clinical outcomes

Chora and colleagues show that infection of the liver by Plasmodium modulates severity of disease in the experimental cerebral malaria (ECM) model by generating gamma delta (y delta) T cells that produce IL-17. This work calls into question the long-standing assumption that liver infection does not modulate severity of malaria.

Automated summary

Chora and colleagues have demonstrated that liver infection in severe malaria cases modulates the severity of the experimental cerebral malaria (ECM) model by generating gamma delta (y delta) T cells that produce IL-17. This research challenges the long-standing assumption that liver infection does not influence the severity of malaria.