4.7 Article

Microbial endocrinology: the mechanisms by which the microbiota influences host sex steroids

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone DispositionS

Abdul Basit et al.

Summary: This study investigated the pharmacokinetics of testosterone and the role of UGT2B17 gene deletion and gut bacterial /3-glucuronidases. It revealed that certain enzymes, such as AKR1D1 and AKR1C4, are involved in testosterone metabolism, and gut bacterial /3-glucuronidases can activate testosterone. These findings are crucial for understanding testosterone metabolism and associated pathophysiological conditions.

DRUG METABOLISM AND DISPOSITION (2023)

Article Microbiology

3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males

Di Li et al.

Summary: Testosterone deficiency can lead to depressive symptoms, and gut microbes expressing 3β-HSD may be associated with depressive symptoms caused by testosterone degradation.

CELL HOST & MICROBE (2022)

Article Multidisciplinary Sciences

Human gut bacteria produce TH17-modulating bile acid metabolites

Donggi Paik et al.

Summary: This study identifies bile acids produced by gut bacteria that inhibit the differentiation of T(H)17 cells, a key immune cell type involved in inflammatory disorders such as inflammatory bowel disease. The levels of these bile acids are reduced in patients with inflammatory bowel disease and are inversely correlated with the expression of T(H)17-cell-associated genes.

NATURE (2022)

Review Medicine, General & Internal

Comamonas testosteroni bacteremia: A rare unusual pathogen detected in a burned patient: Case report and literature review

Ayham Sammoni et al.

Summary: This case report highlights a rare multidrug-resistant infection caused by Comamonas testosteroni, emphasizing the importance of careful antibiotic use and the alarming spread of nosocomial infections.

ANNALS OF MEDICINE AND SURGERY (2022)

Article Microbiology

Long-term high loading intensity of aerobic exercise improves skeletal muscle performance via the gut microbiota-testosterone axis

Lidong Zhang et al.

Summary: Exercise has been found to have a positive impact on skeletal muscle performance, possibly through its effects on gene expression, grip strength, serum testosterone levels, and muscle cross-sectional area. Furthermore, exercise can alter the structure of the gut microbiota, which may be related to testosterone production.

FRONTIERS IN MICROBIOLOGY (2022)

Review Physiology

Tenets in Microbial Endocrinology: A New Vista in Teleost Reproduction

Ramjanul Haque et al.

Summary: Climate vulnerability and changes in aquatic environment can affect the metabolism, physiology, and reproduction of teleost. The control of reproductive function in aquaculture is crucial for sustainable production. Probiotics have various benefits in aquaculture, including promoting growth, improving stress tolerance, inhibiting pathogens, enhancing nutrient digestion and metabolism, and improving reproductive performance. The gut microbiota plays a role in the Gut-Brain-Gonad axis and can influence fish reproduction through various compounds. Further research is needed to understand the precise mechanism of gut microbial composition on brain function in fish.

FRONTIERS IN PHYSIOLOGY (2022)

Review Environmental Sciences

Triclosan and triclocarban as potential risk factors of colitis and colon cancer: Roles of gut microbiota involved

Katherine Z. Sanidad et al.

Summary: In recent years, there has been a significant increase in the occurrence of inflammatory bowel disease (IBD), a chronic inflammatory disease of the intestines. Exposure to the chemicals triclosan (TCS) and triclocarban (TCC) may contribute to the development of IBD and associated diseases, as studies have shown that exposure to these chemicals increases the severity of colitis and exacerbates colon tumorigenesis in mice. The presence of gut microbiota is necessary for the toxic effects of these compounds.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Environmental Sciences

Characterization and Degradation Pathways of Microbacterium resistens MZT7, A Novel 17β-Estradiol-Degrading Bacterium

Peng Hao et al.

Summary: A highly efficient E2-degrading bacterial strain, Microbacterium resistens MZT7, was isolated and characterized. The strain showed excellent adaptability and degradation efficiency towards E2. Three metabolic pathways were proposed and one pathway was confirmed through gene identification. This study provides important insights into the degradation of E2.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Genetics & Heredity

In-Silico Characterization of Estrogen Reactivating β-Glucuronidase Enzyme in GIT Associated Microbiota of Normal Human and Breast Cancer Patients

Fatima Muccee et al.

Summary: This study explores the GUS enzymes encoded by the gut microbiome in normal individuals and breast cancer patients, analyzing their protein characteristics, sub-cellular localization, and structural features. The findings show differences in enzyme sub-cellular localization between breast cancer patients and normal individuals, as well as potential drugability. These discoveries suggest the possibility of using modified GUS enzymes for the treatment of breast cancer tumors.

GENES (2022)

Article Microbiology

A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria

Lina Yao et al.

Summary: This study characterizes a biosynthetic pathway in gut bacteria that sulfonates steroidal metabolites, potentially impacting immune cell trafficking and inflammatory bowel disease.

NATURE MICROBIOLOGY (2022)

Article Cell Biology

Gut feelings about bacterial steroid-17,20-desmolase

Lindsey K. Ly et al.

Summary: Technological advances are beginning to uncover the intricate interactions between hosts and their resident microbiota, which have co-evolved over centuries. The host-associated microbiome is implicated in the production of potent androgens by generating 11 beta-hydroxyandrostenedione. Microbial steroid-17,20-desmolase is capable of cleaving the side-chain of glucocorticoids and drugs, showcasing the gut microbiome's ability to mirror the host's metabolism. Additionally, the role of intestinal steroidogenesis and efflux pumps in transporting glucocorticoids into the gut is discussed, with potential health implications for colonocytes, immune cells, and prostate cells.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

Article Multidisciplinary Sciences

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

Nicolo Pernigoni et al.

Summary: The gut microbiota enriched for species capable of converting androgen precursors into active androgens was found to contribute to the onset of castration resistance in CRPC. Ablation of the gut microbiota by antibiotic therapy delayed the emergence of castration resistance in mice. Fecal microbiota transplantation from CRPC patients rendered mice resistant to castration.

SCIENCE (2021)

Review Immunology

Microbiota-Host-Irinotecan Axis: A New Insight Toward Irinotecan Chemotherapy

Bei Yue et al.

Summary: Irinotecan (CPT11) and its active metabolite SN38 are broad-spectrum cytotoxic anticancer agents that can cause gastrointestinal toxicity. The gut microbiota plays a crucial role in modulating the efficacy and toxicity of CPT11 chemotherapy through mechanisms such as microbial ecocline, enzyme catalysis, and immunoregulation. Targeting the gut microbiota with specific inhibitors, dietary interventions, probiotics, and strain-engineered interventions can potentially improve CPT11 chemotherapy efficiency and alleviate toxicity.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Review Microbiology

The Gut Microbiome and Sex Hormone-Related Diseases

Song He et al.

Summary: This review sheds light on the crosstalk between sex hormones and the gut microbiome, demonstrating that sex differences influence the composition of the gut microbiome. The gut microbiome can be shaped by the hormonal environment, and bidirectional interactions with the hormonal system have been observed.

FRONTIERS IN MICROBIOLOGY (2021)

Review Cell Biology

The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer

Yue Sui et al.

Summary: In recent years, there has been increasing attention on the role of gut microbial beta-glucuronidase in the pathogenesis of breast cancer due to its ability to reactivate estrogen. Although research in this area is still in its early stages, investigators have begun to explore the relationship between microbial beta-glucuronidase-estrogen metabolism-breast cancer axis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Chemistry, Analytical

Simultaneous measurement of free and conjugated estrogens in surface water using capillary liquid chromatography tandem mass spectrometry

Fan Huang et al.

Summary: In this study, a modified derivatisation-based methodology combined with liquid chromatography tandem mass spectrometry was successfully applied for the simultaneous determination of estrogens in environmental samples, including various isomers. Optimization of solid phase extraction and enhancement of mass spectrometric signal led to satisfactory recovery and good linearity, demonstrating the repeatability and sensitivity of the method. The established methodology was effectively used to analyze the concentration of estrogens in natural water samples, with three free estrogens and two sulphate estrogens being detected above their method quantification limits.

ANALYST (2021)

Review Cardiac & Cardiovascular Systems

Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases

Lijuan Jiao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Toward Understanding Microbiome-Neuronal Signaling

K. G. Jameson et al.

MOLECULAR CELL (2020)

Review Endocrinology & Metabolism

NAFLD and NASH in Postmenopausal Women: Implications for Diagnosis and Treatment

Johanna K. DiStefano

ENDOCRINOLOGY (2020)

Article Microbiology

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level

Douglas J. Kenny et al.

CELL HOST & MICROBE (2020)

Article Biochemistry & Molecular Biology

Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases

Samantha M. Ervin et al.

BIOCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Production aspects of testosterone by microbial biotransformation and future prospects

Krishika Sambyal et al.

STEROIDS (2020)

Article Gastroenterology & Hepatology

Erectile Dysfunction Is Highly Prevalent in Men With Newly Diagnosed Inflammatory Bowel Disease

E. Shmidt et al.

INFLAMMATORY BOWEL DISEASES (2019)

Article Multidisciplinary Sciences

Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases

Kristen A. Biernat et al.

SCIENTIFIC REPORTS (2019)

Article Urology & Nephrology

The Microbiome and Prostate Cancer Risk

Karen M. Wheeler et al.

CURRENT UROLOGY REPORTS (2019)

Article Endocrinology & Metabolism

The gut microbiota is a major regulator of androgen metabolism in intestinal contents

Hannah Collden et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Article Biochemistry & Molecular Biology

Gut microbial ?-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Samantha M. Ervin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Genetics & Heredity

Testosterone Degradative Pathway of Novosphingobium tardaugens

Juan Ibero et al.

GENES (2019)

Review Cell Biology

The Microbiome-Estrogen Connection and Breast Cancer Risk

Sheetal Parida et al.

CELLS (2019)

Review Microbiology

Low diversity gut microbiota dysbiosis: drivers, functional implications and recovery

Michael Kriss et al.

CURRENT OPINION IN MICROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase

Saravanan Devendran et al.

JOURNAL OF LIPID RESEARCH (2018)

Article Chemistry, Multidisciplinary

Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

Samuel J. Pellock et al.

ACS CENTRAL SCIENCE (2018)

Article Biotechnology & Applied Microbiology

Steroid Degradation in Comamonas testosteroni TA441: Identification of Metabolites and the Genes Involved in the Reactions Necessary before D-Ring Cleavage

Masae Horinouchi et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2018)

Review Biochemistry & Molecular Biology

Glucuronides in the gut: Sugar-driven symbioses between microbe and host

Samuel J. Pellock et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Behavioral Sciences

Why estrogens matter for behavior and brain health

Liisa A. M. Galea et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Review Biochemistry & Molecular Biology

Extra-gonadal sites of estrogen biosynthesis and function

Radwa Barakat et al.

BMB REPORTS (2016)

Article Urology & Nephrology

Role of Estrogens and Estrogen-Like Compounds in Female Sexual Function and Dysfunction

Nanette Santoro et al.

JOURNAL OF SEXUAL MEDICINE (2016)

Article Biochemistry & Molecular Biology

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

A. Sloan Devlin et al.

NATURE CHEMICAL BIOLOGY (2015)

Review Pharmacology & Pharmacy

Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids

Curtis D. Klaassen et al.

DRUG METABOLISM AND DISPOSITION (2015)

Review Endocrinology & Metabolism

Minireview: Gut Microbiota: The Neglected Endocrine Organ

Gerard Clarke et al.

MOLECULAR ENDOCRINOLOGY (2014)

Article Multidisciplinary Sciences

The Gut Microbiota and Developmental Programming of the Testis in Mice

Maha Al-Asmakh et al.

PLOS ONE (2014)

Review Environmental Sciences

Microbial degradation of steroidal estrogens

Chang-Ping Yu et al.

CHEMOSPHERE (2013)

Article Multidisciplinary Sciences

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

Janet G. M. Markle et al.

SCIENCE (2013)

Letter Medicine, General & Internal

Comamonas testosteroni: An Unusual Bacteria Associated with Acute Appendicitis

Gulsum Iclal Bayhan et al.

BALKAN MEDICAL JOURNAL (2013)

Review Geriatrics & Gerontology

The role of estrogen deficiency in skin ageing and wound healing

Elaine Emmerson et al.

BIOGERONTOLOGY (2012)

Article Biochemistry & Molecular Biology

Hydroxysteroid dehydrogenases (HSDs) in bacteria - A bioinformatic perspective

Michael Kisiela et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2012)

Article Geriatrics & Gerontology

The Role of Androgens and Estrogens on Healthy Aging and Longevity

Astrid M. Horstman et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

Review Reproductive Biology

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction

Geoffrey L. Hammond

BIOLOGY OF REPRODUCTION (2011)

Review Endocrinology & Metabolism

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Walter L. Miller et al.

ENDOCRINE REVIEWS (2011)

Article Multidisciplinary Sciences

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Bret D. Wallace et al.

SCIENCE (2010)

Editorial Material Endocrinology & Metabolism

Understanding Estrogen Action during Menopause

Jameel Iqbal et al.

ENDOCRINOLOGY (2009)

Article Gastroenterology & Hepatology

Guidelines for the management of growth failure in childhood inflammatory bowel disease

Robert Heuschkel et al.

INFLAMMATORY BOWEL DISEASES (2008)

Article Endocrinology & Metabolism

Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men

Liesbeth Vandenput et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

Article Engineering, Environmental

17β-estradiol-degrading bacteria isolated from activated sludge

Chang-Ping Yu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2007)

Review Biochemistry & Molecular Biology

Estrogen signaling multiple pathways to impact gene transcription

Maria Marino et al.

CURRENT GENOMICS (2006)

Article Biotechnology & Applied Microbiology

Microbial production of testosterone and testololactone in the culture of Aspergillus terreus

MA Faramarzi et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2004)

Review Endocrinology & Metabolism

Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

AH Payne et al.

ENDOCRINE REVIEWS (2004)

Article Cell Biology

Androgen physiology: unsolved problems at the millennium

JD Wilson et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2002)

Article Agricultural Engineering

Biotransformation of cholesterol using Lactobacillus bulgaricus in a glucose-controlled bioreactor

R Kumar et al.

BIORESOURCE TECHNOLOGY (2001)