☆ 4.6 Review

Bridging biological cfDNA features and machine learning approaches

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Characterization of fragment sizes, copy number aberrations and 4-mer end motifs in cell-free DNA of hepatocellular carcinoma for enhanced liquid biopsy-based cancer detection

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Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities

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Summary: Genetic investigation of tumor heterogeneity and clonal evolution in solid cancers can be aided by analyzing liquid biopsies. However, the amount of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) released by tumors of different entities into the bloodstream may limit the diagnostic potential of liquid biopsy in distinct tumor histologies. Results showed the superiority of cfDNA- over CTC-based mutation profiling, with CTCs potentially serving as a means to detect rare subclones involved in treatment resistance. Further validation in a larger patient cohort is needed for these findings.

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Summary: Analysis of circulating tumor DNA in oncology applications is limited by the amount of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a blood sample. Linear models revealed that tumor mitotic volume, excessive lesion glycolysis, and tumor invasion depth are significant correlates of circulating tumor fraction. The identified correlates suggest that faster growing tumors have higher fractions of circulating tumor DNA.

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Summary: This study investigated the dynamics of personal DNA methylomic profiles of metastatic prostate cancer patients during disease progression and therapy administration. Longitudinal assessment of cfDNA methylation revealed dynamic patterns associated with disease progression and therapy administration, highlighting the potential of using liquid biopsies to study prostate cancer evolution at a methylomic level.

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Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

Naixin Liang et al.

Summary: Deep methylation sequencing aided by a machine-learning classifier allows for the detection of early cancers from plasma samples at dilution factors as low as 1/10,000, with high sensitivity and specificity. This method accurately identifies patients with lung cancer at different disease stages and outperforms other methods in cancer detection.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Oncology

Dynamic Changes of Circulating Tumor DNA Predict Clinical Outcome in Patients With Advanced Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors

Sabrina Weber et al.

Summary: This study evaluated the predictive value of ctDNA changes during ICI treatment for NSCLC patients. Molecular responders showed significantly improved survival outcomes, especially after excluding CH-related variants. The study suggests that on-treatment changes of ctDNA in plasma could provide predictive information for long-term clinical benefit in ICI-treated NSCLC patients.

JCO PRECISION ONCOLOGY (2021)

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Review Oncology

Next-Generation Liquid Biopsies: Embracing Data Science in Oncology

Y. R. Im et al.

Summary: This study discusses the opportunities and challenges arising from increasingly complex cancer liquid biopsy data, how to analyze analog signals using machine learning, and the acceptance that these cancer signals do not necessarily come from the tumor itself.

TRENDS IN CANCER (2021)

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Article Oncology

Profiling of circulating tumor DNA and tumor tissue for treatment selection in patients with advanced and refractory carcinoma: a prospective, two-stage phase II Individualized Cancer Treatment trial

Jakob M. Riedl et al.

Summary: The study evaluated the success of a targeted therapy selected by profiling of ctDNA and tissue in patients with advanced and refractory carcinoma. The results indicate that more innovative approaches to study design and matching algorithms are necessary to achieve improved patient outcomes.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

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Article Medical Laboratory Technology

Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre) analytical Work Flows

Rita Lampignano et al.

CLINICAL CHEMISTRY (2020)

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Article Gastroenterology & Hepatology

Circulating Tumor DNA Analysis for Detection of Minimal Residual Disease After Chemoradiotherapy for Localized Esophageal Cancer

Tej D. Azad et al.

GASTROENTEROLOGY (2020)

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Article Genetics & Heredity

The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB

Diana S. C. Han et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2020)

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Article Oncology

Harmonizing Cell-Free DNA Collection and Processing Practices through Evidence-Based Guidance

Sarah R. Greytak et al.

CLINICAL CANCER RESEARCH (2020)

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Article Medical Laboratory Technology

Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing

Guangzhe Ge et al.

CLINICAL CHEMISTRY (2020)

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Article Medicine, Research & Experimental

Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer

Himisha Beltran et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Cell Biology

Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

Huiyan Luo et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living

Ellen Heitzer et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Article Oncology

Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation

Peiyong Jiang et al.

CANCER DISCOVERY (2020)

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Article Genetics & Heredity

Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors

Christopher G. Smith et al.

GENOME MEDICINE (2020)

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Letter Medical Laboratory Technology

Fragment Size Analysis May Distinguish Clonal Hematopoiesis from Tumor-Derived Mutations in Cell-Free DNA

Francesco Marass et al.

CLINICAL CHEMISTRY (2020)

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Article Medicine, Research & Experimental

Genome-wide plasma DNA methylation features of metastatic prostate cancer

Anjui Wu et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Multidisciplinary Sciences

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

Anne Marie Lennon et al.

SCIENCE (2020)

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Article Genetics & Heredity

Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma

Lennart Raman et al.

GENOME MEDICINE (2020)

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Article Multidisciplinary Sciences

Integrating genomic features for non-invasive early lung cancer detection

Jacob J. Chabon et al.

NATURE (2020)

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Article Oncology

Circulating Tumor DNA Is Capable of Monitoring the Therapeutic Response and Resistance in Advanced Colorectal Cancer Patients Undergoing Combined Target and Chemotherapy

Hua Cao et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

Asaf Zviran et al.

NATURE MEDICINE (2020)

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Article Oncology

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

M. C. Liu et al.

ANNALS OF ONCOLOGY (2020)

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Article Oncology

Integrated epigenetic biomarkers in circulating cell-free DNA as a robust classifier for pancreatic cancer

Feng Cao et al.

CLINICAL EPIGENETICS (2020)

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Article Medicine, General & Internal

Machine learning-based genome-wide interrogation of somatic copy number aberrations in circulating tumor DNA for early detection of hepatocellular carcinoma

Kaishan Tao et al.

EBIOMEDICINE (2020)

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Article Cell Biology

CpG-Islands as Markers for Liquid Biopsies of Cancer Patients

Maximilian Sprang et al.

CELLS (2020)

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Article Biochemistry & Molecular Biology

Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

Farshad Nassiri et al.

NATURE MEDICINE (2020)

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Article Medical Laboratory Technology

Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based ctDNA Assays: A Joint Consensus Recommendation of the BloodPAC's Analytical Variables Working Group

James H. Godsey et al.

CLINICAL CHEMISTRY (2020)

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Article Cell Biology

ctDNA monitoring using patient-specific sequencing and integration of variant reads

Jonathan C. M. Wan et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Detection and characterization of jagged ends of double-stranded DNA in plasma

Peiyong Jiang et al.

GENOME RESEARCH (2020)

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Article Cell Biology

Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics

Ariana Rostami et al.

CELL REPORTS (2020)

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Article Oncology

Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial

Nicholas C Turner et al.

LANCET ONCOLOGY (2020)

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Editorial Material Medical Laboratory Technology

Cell-Free DNA Fragmentomics: The New Omics on the Block

Rossa W. K. Chiu et al.

CLINICAL CHEMISTRY (2020)

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Article Genetics & Heredity

Genome-Wide Analysis of Cell-Free DNA Methylation Profiling for the Early Diagnosis of Pancreatic Cancer

Shengyue Li et al.

FRONTIERS IN GENETICS (2020)

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Article Multidisciplinary Sciences

A mathematical model of ctDNA shedding predicts tumor detection size

Stefano Avanzini et al.

SCIENCE ADVANCES (2020)

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Article Biochemistry & Molecular Biology

Finding new cancer epigenetic and genetic biomarkers from cell-free DNA by combining SALP-seq and machine learning

Shicai Liu et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

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Article Oncology

On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer

Tina Moser et al.

NPJ PRECISION ONCOLOGY (2020)

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Article Biochemical Research Methods

A web-based automated machine learning platform to analyze liquid biopsy data

Hanfei Shen et al.

LAB ON A CHIP (2020)

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Review Oncology

Circulating tumor DNA and liquid biopsy in oncology

David W. Cescon et al.

NATURE CANCER (2020)

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Article Biochemistry & Molecular Biology

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Kun Sun et al.

GENOME RESEARCH (2019)

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Article Multidisciplinary Sciences

Long fragments achieve lower base quality in Illumina paired-end sequencing

Ge Tan et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma

Emil Christensen et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Genome-wide cell-free DNA fragmentation in patients with cancer

Stephen Cristiano et al.

NATURE (2019)

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Article Oncology

Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer

Yuxuan Wang et al.

JAMA ONCOLOGY (2019)

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Article Oncology

Comprehensive DNA methylation analysis of tissue of origin of plasma cell-free DNA by methylated CpG tandem amplification and sequencing (MCTA-Seq)

Xiaomeng Liu et al.

CLINICAL EPIGENETICS (2019)

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Editorial Material Oncology

Circulating Tumor DNA as a Marker for Disease Relapse in Early-Stage Breast Cancer-Bad Blood

Swathi Karthikeyan et al.

JAMA ONCOLOGY (2019)

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Article Oncology

Assessment of Molecular Relapse Detection in Early-Stage Breast Cancer

Isaac Garcia-Murillas et al.

JAMA ONCOLOGY (2019)

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Article Oncology

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

Nathan Wan et al.

BMC CANCER (2019)

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Article Oncology

Perioperative Dynamic Changes in Circulating Tumor DNA in Patients with Lung Cancer (DYNAMIC)

Kezhong Chen et al.

CLINICAL CANCER RESEARCH (2019)

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Article Oncology

Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK plus Lung Cancer

Leora Horn et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

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Article Biochemical Research Methods

Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA

Shu Yi Shen et al.

NATURE PROTOCOLS (2019)

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Article Cell Biology

Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer

Bradon R. McDonald et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Oncology

Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment

Christoph Suppan et al.

CANCERS (2019)

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Article Multidisciplinary Sciences

Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

Peter Ulz et al.

NATURE COMMUNICATIONS (2019)

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Article Medicine, General & Internal

Day-to-day and within-day biological variation of cell-free DNA

Anne Tranberg Madsen et al.

EBIOMEDICINE (2019)

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Article Biochemistry & Molecular Biology

Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers

Maria Panagopoulou et al.

ONCOGENE (2019)

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Review Oncology

Epigenetic therapy in immune-oncology

Peter A. Jones et al.

NATURE REVIEWS CANCER (2019)

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Article Multidisciplinary Sciences

Early Cancer Detection from Multianalyte Blood Test Results

Ka-Chun Wong et al.

ISCIENCE (2019)

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Article Medicine, Research & Experimental

Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA)

Wenhua Liang et al.

THERANOSTICS (2019)

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Article Oncology

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

Ashleigh C. McEvoy et al.

BMC CANCER (2018)

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Article Oncology

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

Oliver A. Zill et al.

CLINICAL CANCER RESEARCH (2018)

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Article Oncology

False-Positive Plasma Genotyping Due to Clonal Hematopoiesis

Yuebi Hu et al.

CLINICAL CANCER RESEARCH (2018)

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Review Biochemical Research Methods

Machine learning to detect signatures of disease in liquid biopsies - a user's guide

Jina Ko et al.

LAB ON A CHIP (2018)

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Article Biochemistry & Molecular Biology

CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data

Wenyuan Li et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Multidisciplinary Sciences

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Joshua D. Cohen et al.

SCIENCE (2018)

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Article Multidisciplinary Sciences

Evaluation of pre-analytical factors affecting plasma DNA analysis

Havel Markus et al.

SCIENTIFIC REPORTS (2018)

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Article Oncology

Tumor-Specific Mitochondrial DNA Variants Are Rarely Detected in Cell-Free DNA

M. J. A. Weerts et al.

NEOPLASIA (2018)

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Article Medicine, Research & Experimental

Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Florent Mouliere et al.

EMBO MOLECULAR MEDICINE (2018)

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Review Medicine, General & Internal

Application of Cell-free DNA Analysis to Cancer Treatment

Ryan B. Corcoran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Multidisciplinary Sciences

Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma

Peiyong Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cell Biology

Enhanced detection of circulating tumor DNA by fragment size analysis

Florent Mouliere et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Multidisciplinary Sciences

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Joshua Moss et al.

NATURE COMMUNICATIONS (2018)

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Review Medicine, Research & Experimental

Kinetics of circulating cell-free DNA for biomedical applications: critical appraisal of the literature

Sonia Khier et al.

FUTURE SCIENCE OA (2018)

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Article Oncology

Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer

C. Fribbens et al.

ANNALS OF ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Comparative analysis of 12 different kits for bisulfite conversion of circulating cell-free DNA

Mai-Britt Worm Orntoft et al.

EPIGENETICS (2017)

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Article Biochemistry & Molecular Biology

UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy

Tom Smith et al.

GENOME RESEARCH (2017)

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Article Pathology

A Comparison of Cell-Free DNA Isolation Kits Isolation and Quantification of Cell-Free DNA in Plasma

Laure Sorber et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2017)

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Article Multidisciplinary Sciences

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Christopher Abbosh et al.

NATURE (2017)

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Article Genetics & Heredity

Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA

Shicheng Guo et al.

NATURE GENETICS (2017)

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Review Oncology

Integrating liquid biopsies into the management of cancer

Giulia Siravegna et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Cell Biology

Direct detection of early-stage cancers using circulating tumor DNA

Jillian Phallen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Letter Medical Laboratory Technology

Single-Stranded DNA Library Preparation Does Not Preferentially Enrich Circulating Tumor DNA

Tina Moser et al.

CLINICAL CHEMISTRY (2017)

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Article Medical Laboratory Technology

DNA of Erythroid Origin Is Present in Human Plasma and Informs the Types of Anemia

W. K. Jacky Lam et al.

CLINICAL CHEMISTRY (2017)

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Article Oncology

Correlation between circulating mutant DNA and metabolic tumour burden in advanced non-small cell lung cancer patients

Anne Winther-Larsen et al.

BRITISH JOURNAL OF CANCER (2017)

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Review Oncology

Liquid biopsies come of age: towards implementation of circulating tumour DNA

Jonathan C. M. Wan et al.

NATURE REVIEWS CANCER (2017)

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Article Biotechnology & Applied Microbiology

CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA

Shuli Kang et al.

GENOME BIOLOGY (2017)

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Article Biochemical Research Methods

A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies

Andrew E. Teschendorff et al.

BMC BIOINFORMATICS (2017)

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Article Multidisciplinary Sciences

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

Faiyaz Notta et al.

SCIENCE (2016)

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Article Biochemistry & Molecular Biology

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

Matthew W. Snyder et al.

CELL (2016)

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Article Medical Laboratory Technology

Cell-free DNA in maternal plasma and serum: A comparison of quantity, quality and tissue origin using genomic and epigenomic approaches

Felix C. K. Wong et al.

CLINICAL BIOCHEMISTRY (2016)

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Article Biotechnology & Applied Microbiology

Integrated digital error suppression for improved detection of circulating tumor DNA

Aaron M. Newman et al.

NATURE BIOTECHNOLOGY (2016)

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Article Genetics & Heredity

Inferring expressed genes by whole-genome sequencing of plasma DNA

Peter Ulz et al.

NATURE GENETICS (2016)

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Article Multidisciplinary Sciences

Identification of tissue-specific cell death using methylation patterns of circulating DNA

Roni Lehmann-Werman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell Biology

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

Florian Scherer et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Article Genetics & Heredity

Fragment Length of Circulating Tumor DNA

Hunter R. Underhill et al.

PLOS GENETICS (2016)

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Article Biotechnology & Applied Microbiology

Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

Maxim Ivanov et al.

BMC GENOMICS (2015)

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Article Multidisciplinary Sciences

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

Kun Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

Peiyong Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Biotechnology & Applied Microbiology

Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains

Taylor J. Jensen et al.

GENOME BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

Aaron M. Newman et al.

NATURE MEDICINE (2014)

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Article Cell Biology

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Chetan Bettegowda et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Article Medical Laboratory Technology

High-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing

Stephanie C. Y. Yu et al.

CLINICAL CHEMISTRY (2013)

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Review Oncology

Liquid biopsy: monitoring cancer-genetics in the blood

Emily Crowley et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2013)

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Article Biochemical Research Methods

DNA methylation arrays as surrogate measures of cell mixture distribution

Eugene Andres Houseman et al.

BMC BIOINFORMATICS (2012)

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Review Biotechnology & Applied Microbiology

The importance of examining the proportion of circulating DNA originating from tumor, microenvironment and normal cells in colorectal cancer patients

Florent Mouliere et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2012)

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Article Multidisciplinary Sciences

Detection of ultra-rare mutations by next-generation sequencing

Michael W. Schmitt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Cell Biology

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

Tim Forshew et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Article Multidisciplinary Sciences

High Fragmentation Characterizes Tumour-Derived Circulating DNA

Florent Mouliere et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

Detection and quantification of rare mutations with massively parallel sequencing

Isaac Kinde et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Review Oncology

Cell-free nucleic acids as biomarkers in cancer patients

Heidi Schwarzenbach et al.

NATURE REVIEWS CANCER (2011)

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Article Cell Biology

Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the Fetus

Y. M. Dennis Lo et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

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Review Biochemical Research Methods

Cross-validation of component models: A critical look at current methods

R. Bro et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors

Anna V. Cherepanova et al.

CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM V (2008)

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Article Biochemistry & Molecular Biology

Circulating mutant DNA to assess tumor dynamics

Frank Diehl et al.

NATURE MEDICINE (2008)

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Letter Medical Laboratory Technology

The origin of circulating free DNA

Maniesh van der Vaart et al.

CLINICAL CHEMISTRY (2007)

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Article Medical Laboratory Technology

About the possible origin and mechanism of circulating DNA - Apoptosis and active DNA release

M Stroun et al.

CLINICA CHIMICA ACTA (2001)

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