Understanding chaperone specificity: evidence for a 'client code'

The interactions of molecular chap-erones with clients can be regulated by chaperone post-translational modification (PTMs) collectively known as the 'chaperone code'. What is less understood is how PTMs on client proteins may impact chaperone-client interactions. In this forum, we discuss the possibility of a 'client code'.

Automated summary

The interactions between molecular chaperones and their clients can be influenced by post-translational modifications (PTMs) on chaperones, known as the 'chaperone code'. However, it is still not well understood how PTMs on client proteins may affect chaperone-client interactions. In this forum, we explore the potential of a 'client code' that may play a role in these interactions.