Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 162, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2023.117022
Keywords
Metabolome; Exposome; Environmental risk; Health effect; Isotope labeling; Targeted analysis; Non-targeted screening
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Metabolomics and exposomics play important roles in the study of human health and diseases. The combination of chemical isotope labeling (CIL) and mass spectrometry (MS) not only improves sensitivity but also provides benefits in terms of selectivity, accuracy, omics coverage, and analysis throughput. MS-based CIL techniques have been increasingly used in metabolome and exposome analysis.
Metabolomics and exposomics are important in the studies of human health and diseases. Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only improve sensitivity but also bring significant benefits for selectivity, accuracy, omics coverage, and analysis throughput. Therefore, MS-based CIL techniques have been increasingly used in metabolome and exposome analysis. In this review, we summarize the advantages of MS-based CIL techniques in sensitivity, accuracy, selectivity, stability, analysis throughput, and applicability, and also discuss the potential shortcomings. Moreover, based on five subgroups of representative metabolites and xenobiotics containing amino, carboxyl, carbonyl, hydroxyl and sulfhydryl groups, we review the advances of MS-based CIL techniques in tar- geted and not-targeted analysis. Notably, some novel CIL techniques emerged in the structural design of CIL reagents has also discussed. Finally, we give our perspective on the future of MS-based CIL techniques in this field, especially on the structural design of ideal CIL reagents.(c) 2023 Elsevier B.V. All rights reserved.
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