Overexpressed miRNA-nov-1 promotes manganese-induced apoptosis in N27 cells by regulating Dhrs3 to activate mTOR signaling pathway

Review Environmental Sciences

The expression of microRNAs and exposure to environmental contaminants related to human health: a review

Maria Rosaria Tumolo et al.

Summary: This review provides an overview of studies investigating the impact of air pollution, organic chemicals, and heavy metals on miRNA expression and the potential biologic effects on humans.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2022)

Add to Collection

Article Cell Biology

MiR-135a-5p and Mst1 regulate MPP +-1 induced apoptosis and autophagy in Parkinson?s disease model in vitro

Yinying Qin et al.

Summary: This study reveals the important role of Mst1 in regulating neuronal cell death in Parkinson's disease models, and suggests that the miR-135a-5p/Mst1 axis could be a potential therapeutic target for PD treatment.

CELLULAR SIGNALLING (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinson's Disease Pathogenesis via Pink1/Parkin-Dependent Mitophagy

Xiaolin Dong et al.

Summary: miR-421 regulates neuronal cell mitophagy through the Pink1/Parkin pathway, which is of great significance for the treatment of PD.

DISEASE MARKERS (2022)

Add to Collection

Article Endocrinology & Metabolism

LncRNA RMST Regulates Neuronal Apoptosis and Inflammatory Response via Sponging miR-150-5p in Parkinson's Disease

Chuanlei Chen et al.

Summary: The study found that serum RMST levels were elevated in both PD patients and PD cell models, with potential clinical diagnostic value for PD. RMST may regulate the occurrence and development of PD by inhibiting neuron cell apoptosis and targeting miR-150-5p to release inflammatory cytokines.

NEUROIMMUNOMODULATION (2022)

Add to Collection

Article Biochemistry & Molecular Biology

CircAXL Knockdown Alleviates Aβ1-42-Induced Neurotoxicity in Alzheimer's Disease via Repressing PDE4A by Releasing miR-1306-5p

Shengxi Meng et al.

Summary: This study found that circAXL plays an important role in the development of Alzheimer's disease. Knockdown of circAXL can alleviate cell cytotoxicity, cell apoptosis, inflammation, oxidative stress, and endoplasmic reticulum stress in AD pathology.

NEUROCHEMICAL RESEARCH (2022)

Add to Collection

Article Toxicology

Long noncoding RNA Sh2d3c promotes manganese-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax axis

Wenmin Lu et al.

Summary: This study reveals the role of lncRNAs in Mn-induced neurotoxicity, identifying lncSh2d3c as a key regulatory factor that is involved in Mn-induced neuronal apoptosis through the mmu-miR-675-5p/Chmp4b/Bax pathway. This finding suggests a novel mechanism of Mn-induced neurotoxicity and highlights the potential of lncSh2d3c as a therapeutic target.

TOXICOLOGY LETTERS (2022)

Add to Collection

Article Cell Biology

Hypermethylation of DHRS3 as a Novel Tumor Suppressor Involved in Tumor Growth and Prognosis in Gastric Cancer

Sha Sumei et al.

Summary: This study revealed that DHRS3 is hypermethylated and downregulated in gastric cancer, associated with histological type and differentiation of tumors. Patients with high levels of CpG 9.10 methylation in DHRS3 had shorter survival times.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Cell Biology

The role of exosomal microRNAs in central nervous system diseases

Yifei Yu et al.

Summary: miRNAs play a crucial role in regulating gene expression, while the exchange of miRNAs within exosomes is important in CNS diseases. Exosomal miRNAs can serve as a novel therapeutic strategy and diagnostic tool for neurological diseases.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Add to Collection

Article Oncology

circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR-29c-3p-mediated AMPK/mTOR pathway in Parkinson's disease

Wensheng Wang et al.

Summary: This study investigated the pathogenesis of Parkinson's disease and identified that circSAMD4A modulates apoptosis and autophagy of dopaminergic neurons through the AMPK/mTOR cascade via miR-29c-3p in PD.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Oncology

Long non-coding RNA SNHG1 mediates neuronal damage in Parkinson's disease model cells by regulating miR-216a-3p/Bcl-2-associated X protein

Hai Wang et al.

Summary: The study elucidated the relationship and mechanism of SNHG1 and miR-216a-3p in Parkinson's disease (PD), revealing their regulatory roles in cell activity and apoptosis. BAX plays a crucial role in this regulatory network.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology