A double-edged sword of platelet-derived extracellular vesicles in tissues, injury or repair: The current research overview

Extracellular vesicles (EVs) are vesicular bodies with a double-layered membrane structure that are detached from the cell membrane or secreted by the cells. EVs secreted by platelets account for the main part in the blood circulation, which account for about 30% or even more. Many types of cells are regulated by PEVs, including endothelial cells, leukocytes, smooth muscle cells, etc. Nevertheless, despite the growing interest in the study of extracellular vesicles, there are still only a few studies on the role of PEVs. Therefore, this overview mainly focuses on one method of isolation and the functions of PEVs in tissues found so far, including promoting tissue repair and mediating tissue damage, which can be used for researchers to continue to explore the role of PEVs in other fields.

Automated summary

Extracellular vesicles (EVs) are vesicular bodies detached from the cell membrane or secreted by cells, with a double-layered membrane structure. EVs secreted by platelets account for the main part in the blood circulation, and they regulate various types of cells. However, there are still limited studies on the role of PEVs. This overview focuses on isolation methods and the functions of PEVs in tissues, such as tissue repair and tissue damage mediation, providing a basis for further research on the role of PEVs in other fields.