Linalool prevents kidney damage by inhibiting rifampicin-induced oxidative stress and apoptosis

Today, kidney diseases are increasing day by day and life quality is decreasing. In hospitalized patients of all ages, acute kidney injury (AKI) is commonly observed and associated with high rates of morbidity and mortality. Rifampicin (RF) or rifampin is an antibiotic drug from the rifamycin group with a bactericidal effect. RF causes acute kidney injury, often anemia, thrombocytopenia, liver damage and side effect such as cell death. RF causes tissue damage by means of oxidative stress and apoptosis. Thus, in this study, it was examined whether linalool (LN) which had antinociceptive, antimicrobial, antioxidant and anti-inflammatory effects, was beneficial for kidney damage in order to eliminate the side effects of RF. NGAL mRNA, creatinine (Cr), blood urea nitrogen (BUN), Caspase 9 (CAS-9) and nuclear factor-kappa B (NF-kappa B) levels increased in the group treated with RF compared to the control group, while the levels of albumin, uric acid and total protein were decreased in the RF-treated group. NGAL mRNA, BUN, Cr, CAS-9 and NF-kappa B levels decreased significantly in RF+LN administered rats, while it was observed that there was an increase in the levels of albumin, uric acid and total protein. From the results obtained, it was observed that LN was determined to be very effective in preventing tissue damage in kidneys caused by oxidative stress by RF.

Automated summary

Currently, kidney diseases are on the rise, leading to a decrease in quality of life. Acute kidney injury (AKI) is commonly seen in hospitalized patients of all ages and is associated with high morbidity and mortality rates. Rifampicin (RF), an antibiotic from the rifamycin group, can cause acute kidney injury as well as side effects such as anemia, thrombocytopenia, and liver damage. This study investigated the potential benefits of linalool (LN), which has antinociceptive, antimicrobial, antioxidant, and anti-inflammatory effects, in alleviating kidney damage caused by RF-induced oxidative stress.