Journal
TETRAHEDRON LETTERS
Volume 123, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2023.154539
Keywords
NCBSI; DCE; Esters
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An efficient and fast method for synthesizing esters from N-alkoxyamides has been reported using easily available N-Chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI). This metal and ligand-free protocol occurs under mild reaction conditions and can incorporate a wide variety of amides, leading to the formation of functionalized esters with high yields, highlighting its versatility and chemoselectivity.
An efficient, fast method for ester synthesis from N-alkoxyamides has been reported. This protocol used easily available N-Chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) for conversion of alkoxy amides to the corresponding esters. The present methodology is metal and ligand-free and takes place under mild reaction conditions. This transformation incorporates a wide variety of amides, prepared from either aryl or alkyl carboxylic acid, leading to the formation of functionalized esters highlighting its ver-satility, chemoselectivity, and high yielding aspects.& COPY; 2023 Elsevier Ltd. All rights reserved.
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